Breast Cancer Multiomics: Unified Insights in Tumor Heterogeneity, Upcoming Webinar Hosted by Xtalks

In this free webinar, explore a new method detailing genetic insights into breast cancer, enabling precise assessment of variations, gene expressions and targeted proteins at a single-cell level. Attendees will gain insights into the heterogeneity seen in single-cell evaluations of early-stage tumors. The featured speaker will discuss the linkage between tumor genomes and transcriptomes.

TORONTO, Dec. 12, 2023 /PRNewswire-PRWeb/ -- Discover an innovative webinar exploring a novel single-cell method for breast cancer multiomics, linking genetic variations, copy number changes and gene expressions with focused panels. While the information obtained from whole genome sequencing (WGS) studies is a clear gold standard for discovery-based sequencing, current sequencing costs and informatics challenges frequently diminish WGS usage. Instead, applications focus on exonic spaces, particularly druggable targets. The majority of these are small, focused panels — resulting in a significant resolution gap between comprehensive WGS and these focal panels.

In this webinar, the featured speaker describes the utility of the IDT v2 exome hybrid capture after ResolveOME single-cell workflow in a cohort of cells derived from breast cancer patients. This enables single-cell resolution of single nucleotide variants (SNVs), copy number alterations and gene expression signatures with a small, targeted protein panel, allowing for a true multiomic assessment of this disease.

Briefly, prior to hybrid capture, the corresponding single-cell genomic libraries were subjected to low-coverage WGS (lcWGS) to ascertain copy number alterations, revealing ductal carcinoma in situ/ infiltrating ductal carcinoma of the breast (DCIS/IDC)-prototypical and heterogeneous chromosomal lesions. Full-transcript RNA-seq data and BioLegend antibody-based surface protein targets were jointly assessed from the transcriptomic libraries of ResolveOME, enabling cell type identification and phenotypic cell state inference. The data indicates the successful merging of the ResolveOME multiomic workflow with a single-cell exome survey, enabling analysis of copy number variants (CNV) in the context of a complete transcriptome with a focal targeted protein assessment.

Join this webinar to explore a new method detailing genetic insights into breast cancer, enabling precise assessment of variations, gene expressions and targeted proteins at a single-cell level.

Join Katie Kennedy, PhD, ASCP (MB), Manager Services Department, BioSkryb Genomics, for the live webinar on Monday, December 18, 2023, at 2 pm EST (11 am PST).

For more information, or to register for this event, visit Breast Cancer Multiomics: Unified Insights in Tumor Heterogeneity.

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Vera Kovacevic, Xtalks, +1 (416) 977-6555 x371, [email protected] 

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