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How corporate involvement in psychedelic research could threaten public safety

Retrieved on: 
Tuesday, April 23, 2024

With an increasing cultural spotlight, there has been substantial economic growth of the psychedelic drugs market.

Key Points: 
  • With an increasing cultural spotlight, there has been substantial economic growth of the psychedelic drugs market.
  • Legislative restrictions have made it difficult to obtain government funding for psychedelic research, but now corporations are stepping up to fund clinical trials.

How conflicts of interest impact psychedelic research


Corporations work to pursue profit for shareholders, a motivational bias that differs from the goal of science which is to report findings as accurately as possible. At the same time, industry benefits the field by introducing new potential therapies. Nonetheless, there are numerous ways in which conflicts of interest may challenge scientific integrity in psychedelic trials:
Research topic selection: Corporations tend to prioritize research fields related to products that can be best commercialized.
Investigator psychology: Researchers may receive “gifts” from corporations, introducing a social and professional pressure to conform with their expectations and wishes.
Substance selection: Corporate interests are likely to favour substances that can be patented.
Population selection: Corporate interests may advocate for strict screening when recruiting volunteers to increase the chance of positive outcomes. This may result in the study cohort being easier to treat, which limits the generalizability of the results to real-world populations.
Study design: Corporate interests may favour study designs that are more likely to indicate statistically significant effectiveness, and less likely to identify adverse events.
Cost minimization: Corporate interests may favour less frequent sessions or follow-ups, reduced monitoring and fewer open interviews with participants in an effort to reduce costs. These changes make it more difficult to identify adverse events and might allow them to go unreported.
Reporting: Publication bias may occur in which scientific journals are more likely to publish positive findings, and negative findings remain unpublished.
Media engagement: Corporate interests may favour sensationalist media narratives that are not balanced. An emphasis on positive results can skew the public perception of psychedelics.
Participant psychology: Selective reporting in the media may contribute to “excessive enthusiasm” and expectancy bias in participants and researchers. This happens when individuals with positive views about psychedelics are more likely to volunteer for studies and expect positive outcomes.

Consequences for public health

  • The influence of conflicts of interest on psychedelic studies can contribute to an overly optimistic opinion by researchers, the public and policymakers.
  • This may pose safety risks to the public if legislative changes that increase access are made prematurely, as witnessed with tobacco and opioid industries in the past.

What we can do about it


There are a few ways to address these challenges:
Promote alternate funding sources: Government funding opportunities will allow psychedelic clinical trials to occur without or with partial corporate involvement.
Transparent reporting of corporate involvement: Disclosure of conflicts of interest is key in fuelling trust and allowing critical interpretation of findings.
Responsible reporting in the media: Sensationalist media coverage promotes inaccurate narratives, such as the ability of psychedelics to “cure” mental illness with one dose. Standards of reporting can be developed to ensure that media reports are as accurate as possible.
Research regulations and standards: Clinical trial protocols should be registered before the research acquires any corporate funding, with safety data as a main result. The inclusion of independent arbiters could help determine if any adverse events are related to the treatment.
Public education: Media literacy and public education programs, and ethical science communication, could help the public better understand psychedelic research results as well as promote informed policy changes and safe use.
Funding real-world evidence: Research funding agencies should support real-world cohort studies measuring long-term effects and health outcomes of psychedelic use.
Considering how to reduce the impact of conflicts of interest on psychedelic studies could help avoid public health risks and further setbacks on research efforts for these potentially life-saving therapies. While market-driven solutions have contributed to the development of life-changing therapies, more awareness is needed for how corporate interests may threaten research integrity and pose public safety risks in the pursuit of profit.

  • Elisa Brietzke receives funding from PSI Foundation (unrelated to this article) and Queen's University School of Medicine.
  • Marco Solmi receives funding from CIHR, and has received honoraria/has been a consultant for AbbVie, Angelini, Lundbeck, Otsuka.

Why you shouldn’t be afraid to start running after middle age

Retrieved on: 
Friday, April 19, 2024

As someone who started marathon running in mid-life, I know how many aches and pains (and doubts) you can have if you take on the challenge to start running at an older age.

Key Points: 
  • As someone who started marathon running in mid-life, I know how many aches and pains (and doubts) you can have if you take on the challenge to start running at an older age.
  • Hobbling around my orthopaedic hospital after my first marathon actually led me to do research on runners.
  • The high-resolution MRI scans found most of the 115 middle-aged participants had abnormalities in their knees before starting marathon training.
  • But while osteoarthritis is more common after middle age, it may actually be a lack of activity that leads to osteoarthritis.
  • Reduced muscle use, whether it is through inactivity or sarcopenia or both, also reduces the production of anti-inflammatory myokines from the muscles.
  • These chemicals are released when we exercise, and help reduce joint swelling and calm irritated joint linings.
  • This effect is pronounced in runners because running uses some of the largest muscles in the body – such as the glutes, quadriceps and hamstrings.

Where to begin

  • If you want to start running, the main message is to ease into it to reduce the risk of injury.
  • One of the best ways to ease into running in mid-life is the NHS Couch to 5K running programme.
  • It’s a free guide that will help you gradually work up towards running 5km in just nine weeks.
  • If you’ve experienced any of these problems, you’ll want to be careful when exercising to avoid further damage.


Alister Hart receives funding from 3 charities: The Rosetrees Trust, Arthroplasty for Arthritis and The Maurice Hatter Foundation.

Billions of cicadas are about to emerge from underground in a rare double-brood convergence

Retrieved on: 
Thursday, April 18, 2024

From late April through June 2024, the largest brood of 13-year cicadas, known as Brood XIX, will co-emerge with a midwestern brood of 17-year cicadas, Brood XIII.

Key Points: 
  • From late April through June 2024, the largest brood of 13-year cicadas, known as Brood XIX, will co-emerge with a midwestern brood of 17-year cicadas, Brood XIII.
  • A co-emergence like this of two specific broods with different life cycles happens only once every 221 years.
  • For about four weeks, scattered wooded and suburban areas will ring with cicadas’ distinctive whistling, buzzing and chirping mating calls.
  • Once the eggs hatch, new cicada nymphs will fall from the trees and burrow back underground, starting the cycle again.
  • It’s no accident that the scientific name for periodical 13- and 17-year cicadas is Magicicada, shortened from “magic cicada.”

Ancient visitors

  • Molecular analysis has shown that about 4 million years ago, the ancestor of the current Magicicada species split into two lineages.
  • The resulting three lineages are the basis of the modern periodical cicada species groups, Decim, Cassini and Decula.
  • The sudden appearance of so many insects reminded them of biblical plagues of locusts, which are a type of grasshopper.
  • During the 19th century, notable entomologists such as Benjamin Walsh, C.V. Riley and Charles Marlatt worked out the astonishing biology of periodical cicadas.

Acting in unison

  • This increases their chances of accomplishing their key mission aboveground: finding mates.
  • While periodical cicadas largely come out on schedule every 17 or 13 years, often a small group emerges four years early or late.
  • Early-emerging cicadas may be faster-growing individuals that had access to abundant food, and the laggards may be individuals that subsisted with less.

Will climate change shift Magicicada clocks?

  • As glaciers retreated from what is now the U.S. some 10,000 to 20,000 years ago, periodical cicadas filled eastern forests.
  • Today there are 12 broods of 17-year periodical cicadas in northeastern deciduous forests, where trees drop leaves in winter.
  • Because periodical cicadas are sensitive to climate, the patterns of their broods and species reflect climatic shifts.
  • Although periodical cicadas prefer forest edges and thrive in suburban areas, they cannot survive deforestation or reproduce successfully in areas without trees.
  • In the late 19th century, one Brood (XXI) disappeared from north Florida and Georgia.
  • Climate change could also have farther-reaching effects.
  • As the U.S. climate warms, longer growing seasons may provide a larger food supply.
  • This may eventually change more 17-year cicadas into 13-year cicadas, just as past warming altered Magicicada neotredecim.
  • We hypothesize that this was due to climate warming.


John Cooley receives funding from the National Science Foundation and the National Geographic Society. Chris Simon has received funding from the National Science Foundation, the Fulbright Foundation, the National Geographic Society and the New Zealand Marsden Fund.

‘Pretty privilege’: attractive people considered more trustworthy, research confirms

Retrieved on: 
Wednesday, April 10, 2024

Beauty is not, as it is often assumed to be, “in the eye of the beholder” – but follows certain predictable rules.

Key Points: 
  • Beauty is not, as it is often assumed to be, “in the eye of the beholder” – but follows certain predictable rules.
  • The fascination for the perfect makeup or skincare is fired up by the impact of perfect faces displayed on social media and enhanced by image processing and filters.

Pretty privilege

  • Numerous studies have shown that attractive individuals benefit from a beauty bonus and earn higher salaries on average.
  • Beautiful individuals are consistently expected to be more intelligent and thought to be better leaders, which influences career trajectories and opportunities.

Does being attractive make you more trustworthy?

  • In our recent paper Adam Zylbersztejn, Zakaria Babutsidze, Nobuyuki Hanaki and I set out to find out.
  • Previous studies presented different portraits of individuals to observers and asked them about their beliefs about these people.
  • Each player’s payoff thus depended on their own actions and/or the actions of the other player:


If player A chooses “Left”, then regardless of player Bs’ choice:
If player A chooses “Right” and player B chooses “Don’t roll”:
If player A chooses “Right” and player B chooses “Roll”:

  • To do so they were presented with the abstract choice scenario explained above while individually sat in a cubicle.
  • If they decided not to trust, they were sure to receive a meagre 5-euro payout for their participation in the study.
  • However, once an A player decided to trust their B partner, their fate was in the B player’s hands.

Does gender come into play?

  • This implies that in our abstract economic exchange, beautiful individuals are more likely to benefit from the trust of others.
  • However, when investigating actual behaviour, we see that beautiful individuals are neither more nor less trustworthy than anyone else.
  • In other words, trustworthiness is driven by good old individual values and personality, which are not correlated with how someone looks.

Are beautiful people more suspicious of their peers?

  • However, we might wonder who is more likely to fall prey to this bias.
  • We constructed our study such that we could also investigate this question.
  • Specifically, the participants we recruited in Lyon to make their predictions also had their photos taken.
  • We thus knew how much they were influenced by the looks of others but also how conventionally good-looking they were themselves.


Astrid Hopfensitz ne travaille pas, ne conseille pas, ne possède pas de parts, ne reçoit pas de fonds d'une organisation qui pourrait tirer profit de cet article, et n'a déclaré aucune autre affiliation que son organisme de recherche.

Roads of destruction: we found vast numbers of illegal ‘ghost roads’ used to crack open pristine rainforest

Retrieved on: 
Wednesday, April 10, 2024

In an article published today in Nature, my colleagues and I show that illicit, often out-of-control road building is imperilling forests in Indonesia, Malaysia and Papua New Guinea.

Key Points: 
  • In an article published today in Nature, my colleagues and I show that illicit, often out-of-control road building is imperilling forests in Indonesia, Malaysia and Papua New Guinea.
  • Once roads are bulldozed into rainforests, illegal loggers, miners, poachers and landgrabbers arrive.
  • Once they get access, they can destroy forests, harm native ecosystems and even drive out or kill indigenous peoples.
  • All nations have some unmapped or unofficial roads, but the situation is especially bad in biodiversity-rich developing nations, where roads are proliferating at the fastest pace in human history.

Mapping ghost roads

  • This workforce then spent some 7,000 hours hand-mapping roads, using fine-scale satellite images from Google Earth.
  • For starters, unmapped ghost roads seemed to be nearly everywhere.
  • In fact, when comparing our findings to two leading road databases, OpenStreetMap and the Global Roads Inventory Project, we found ghost roads in these regions to be 3 to 6.6 times longer than all mapped roads put together.
  • When ghost roads appear, local deforestation soars – usually immediately after the roads are built.
  • We found the density of roads was by far the most important predictor of forest loss, outstripping 38 other variables.

Roads and protected areas

  • In protected areas, we found only one-third as many roads compared with nearby unprotected lands.
  • The bad news is that when people do build roads inside protected areas, it leads to about the same level of forest destruction compared to roads outside them.
  • Keeping existing protected areas intact is especially urgent, given more than 3,000 protected areas have already been downsized or degraded globally for new roads, mines and local land-use pressures.

Hidden roads and the human footprint

  • To gauge how much impact we’re having, researchers use the human footprint index, which brings together data on human activities such as roads and other infrastructure, land-uses, illumination at night from electrified settlements and so on.
  • When ghost roads are included in mapping the human impact on eastern Borneo, areas with “very high” human disturbance double in size, while the areas of “low” disturbance are halved.

Artificial intelligence

  • Worse, these roads can be actively encouraged by aggressive infrastructure-expansion schemes — most notably China’s Belt and Road Initiative, now active in more than 150 nations.
  • You might think AI could do this better, but that’s not yet true – human eyes can still outperform image-recognition AI software for mapping roads.
  • Once we have this information, we can make it public that so authorities, NGOs and researchers involved in forest protection can see what’s happening.


Distinguished Professor Bill Laurance receives funding from the Australian Research Council and other scientific and philanthropic bodies. He is a former Australian Laureate and director of the Centre for Tropical Environmental and Sustainability Science at James Cook University.

Heartfelt Generosity: Adrian Cheng and Natalia Vodianova Arnault Celebrate the Success of The Children Ball in Support of Children with Special Needs

Retrieved on: 
Wednesday, April 10, 2024

The Children Ball – 'A Night of Infinite Hearts, A World Where Every Child Can' was held on 21 March 2024 at Rosewood Hong Kong.

Key Points: 
  • The Children Ball – 'A Night of Infinite Hearts, A World Where Every Child Can' was held on 21 March 2024 at Rosewood Hong Kong.
  • "We have been overwhelmed by the tremendous support we have received," said Adrian Cheng, the host of The Children Ball and founder of The WEMP Foundation.
  • By joining forces, we can effect meaningful change and create a society that prioritises the mental well-being of our children."
  • Since then, the foundation has provided support to 28,014 children and young adults with special needs and their families.

EQS-News: G.ST Antivirals reports start of Phase II trial and announces appointment of Ronald Bruce Turner as new Chief Medical Officer

Retrieved on: 
Wednesday, April 10, 2024

An expert in the clinical research of respiratory viruses, Dr. Turner will oversee the Company’s current clinical trial and drive further clinical development.

Key Points: 
  • An expert in the clinical research of respiratory viruses, Dr. Turner will oversee the Company’s current clinical trial and drive further clinical development.
  • This study aims to assess the effectiveness of 2-DG in preventing illness from rhinoviruses, reducing infection rates, and easing symptom severity.
  • A total of 128 volunteers will participate, receiving up to four daily intranasal doses of either 2-DG or a placebo.
  • 2-DG is a unique and intriguing therapeutic approach to treating viral infections by blocking the virus’ nutrient access,” commented Ronald Bruce Turner, MD, CMO of G.ST Antivirals.

SBA Recognizes 2024 Phoenix Award Winners of the Year for Outstanding Disaster Recovery Efforts

Retrieved on: 
Tuesday, April 9, 2024

WASHINGTON, April 09, 2024 (GLOBE NEWSWIRE) -- Today,  Administrator Isabel Casillas Guzman , head of the U.S. Small Business Administration (SBA) and voice in President Biden’s Cabinet for America’s more than 33 million small businesses, recognized the 2024 Phoenix Award winners for outstanding disaster recovery efforts by a small business, public official, and volunteer.

Key Points: 
  • WASHINGTON, April 09, 2024 (GLOBE NEWSWIRE) -- Today,  Administrator Isabel Casillas Guzman , head of the U.S. Small Business Administration (SBA) and voice in President Biden’s Cabinet for America’s more than 33 million small businesses, recognized the 2024 Phoenix Award winners for outstanding disaster recovery efforts by a small business, public official, and volunteer.
  • “SBA’s 2024 Phoenix Award winners inspire us and remind us that even in the face of disaster, tragedy, or uncertainty, America at its core is about hope, possibilities, and an unwavering commitment to working together to strengthen our communities,” said Administrator Guzman.
  • “These honorees represent the power of determination and adaptability,” said Francisco Sánchez Jr. , Associate Administrator for the Office of Disaster Recovery and Resilience at the Small Business Administration.
  • Jacqueline was first introduced to the SBA back in 2020, receiving an Economic Injury Disaster Loan (EIDL) due to the pandemic.

Partnership for a Drug-Free New Jersey’s Opioid Prevention Initiatives Recognized at National Rx Summit

Retrieved on: 
Thursday, April 4, 2024

PDFNJ highlighted these initiatives, which are critical in providing New Jersey communities with vital information on preventing opioid misuse, as part of the Rx Summit’s poster sessions.

Key Points: 
  • PDFNJ highlighted these initiatives, which are critical in providing New Jersey communities with vital information on preventing opioid misuse, as part of the Rx Summit’s poster sessions.
  • Through this program, more than 10,000 volunteers throughout the state share opioid prevention and awareness messages and materials.
  • “At the Rx Summit, we shared our strategies for reaching New Jersey communities with essential information on preventing opioid misuse,” said Angelo Valente, Executive Director of PDFNJ.
  • Since its inception, the Partnership has garnered 226 advertising and public relations awards from national, regional and statewide media organizations.

National Fitness Partners Launches Fundraising Campaign for Make-A-Wish Foundation

Retrieved on: 
Wednesday, April 3, 2024

CAMP HILL, Pa., April 03, 2024 (GLOBE NEWSWIRE) -- National Fitness Partners (NFP), a leading Planet Fitness franchise division, kicked off its first fundraising campaign to benefit Make-A-Wish, which will run April 1-30.

Key Points: 
  • CAMP HILL, Pa., April 03, 2024 (GLOBE NEWSWIRE) -- National Fitness Partners (NFP), a leading Planet Fitness franchise division, kicked off its first fundraising campaign to benefit Make-A-Wish, which will run April 1-30.
  • During the campaign, National Fitness Partners will encourage members to donate in person to Make-A-Wish at each of their 140 Planet Fitness locations.
  • In addition, National Fitness Partners’ members can participate in the campaign by tracking their mileage on designated treadmills at each location, and National Fitness Partners will donate 5 cents per mile with a $100 cap per location.
  • “National Fitness Partners believes in organizations like the Make-A-Wish Foundation that support the health and wellness of children in our communities,” said Stephen Kindler, Jr., President and CEO of National Fitness Partners.