Ligand

New Paper in Science Reports Discovery of Ultrapotent Chemogenetic Approach that Forms Scientific Foundation for Redpin Therapeutics’ Technology

Retrieved on: 
Thursday, March 14, 2019
Health, Biotechnology, Genetics, Mental health, Pharmaceutical, Branches of biology, Ion channels, Ionotropic receptors, Molecular neuroscience, Cell signaling, Ligand-gated ion channel, Janelia Research Campus, Ligand, Howard Hughes Medical Institute, Androgen receptor

Scott Sternson, Ph.D., Group Leader at the Janelia Research Campus of the Howard Hughes Medical Institute (HHMI), led the study.

Key Points: 
  • Scott Sternson, Ph.D., Group Leader at the Janelia Research Campus of the Howard Hughes Medical Institute (HHMI), led the study.
  • Redpin Therapeutics has a worldwide exclusive license from HHMI for therapeutic use of this technology.
  • The researchers developed a novel method for engineering ligand-gated ion channel receptors to have ultrapotent sensitivity to U.S. Food and Drug Administration (FDA)-approved agonists.
  • These chemogenetic receptors enable the selective control of cells in vivo, which Redpin is developing for potential clinical therapies.

Hello Bio Launches Novel Water-soluble, High Potency DREADD Ligands, Licensed from the NIH

Retrieved on: 
Saturday, March 9, 2019
Branches of biology, Biochemistry, Biology, Signal transduction, Receptor activated solely by a synthetic ligand, Ligand, G protein-coupled receptor, Free base

PRINCETON, N.J., March 09, 2019 /PRNewswire-PRWeb/ -- Hello Bio announces the launch of novel water-soluble and highly potent hM3Dq & hM4Di ligands exciting compounds for scientists studying GPCR and DREADD signalling.

Key Points: 
  • PRINCETON, N.J., March 09, 2019 /PRNewswire-PRWeb/ -- Hello Bio announces the launch of novel water-soluble and highly potent hM3Dq & hM4Di ligands exciting compounds for scientists studying GPCR and DREADD signalling.
  • JHU37160 dihydrochloride and JHU37152 dihydrochloride are novel DREADD ligands with high potency at hM3Dq and hM4Di DREADDs in in vitro functional assays.
  • They are active in vivo, following ip administration, and are available from Hello Bio as both the water-soluble dihydrochloride salts, and freebase forms.
  • Hello Bio was founded by a team of experienced scientists and chemists who genuinely want to support life science research.

Achieve Announces Publication of Cytisine Data for Next-Generation Cytisine Molecules

Retrieved on: 
Monday, June 11, 2018
Chemistry, Nicotinic agonists, Teratogens, Cell signaling, Chemical bonding, Coordination chemistry, Cytisine, Nicotinic acetylcholine receptor, Ligand, Nicotine, Coordination complex, Binding selectivity

Molecular simulation of protein-ligand complexes was also used to understand how structural modifications might modify a ligand's activity profile.

Key Points: 
  • Molecular simulation of protein-ligand complexes was also used to understand how structural modifications might modify a ligand's activity profile.
  • "This effort led by the University of Bristol will enable Achieve to pursue the development of next-generation cytisine treatments, which will be highly-targeted and more potent.
  • The full publication, Unlocking Nicotinic Selectivity via Direct CH Functionalization of ()-Cytisine, is available via Open Access and can be viewed at https://doi.org/10.1016/j.chempr.2018.05.007 .
  • Two prior, large-scale Phase 3 clinical studies of cytisine, with favorable outcomes, have been successfully completed in over 2,000 patients.

Green Science Alliance Co., Ltd. Has Started the Manufacturing and Custom Synthesis of a Metal Organic Framework (MOF), Porous Coordination Polymers (PCPs)

Retrieved on: 
Tuesday, May 8, 2018
Chemistry, Materials science, Porous media, Polymers, Crystal engineering, Metal–organic framework, Membrane technology, Coordination polymer, Zeolite, Separator, Ligand, Porous medium

KAWANISHI, Japan, May 8, 2018 /PRNewswire/ --Metal organic frameworks (MOFs), also known as porous coordination polymers (PCPs), are materials composed of metal cations and polydentate ligands that bridge component metals.

Key Points: 
  • KAWANISHI, Japan, May 8, 2018 /PRNewswire/ --Metal organic frameworks (MOFs), also known as porous coordination polymers (PCPs), are materials composed of metal cations and polydentate ligands that bridge component metals.
  • MOFs are synthesized as superporous materials by modifying their metal and organic ligand, as well as the shape and size of pores.
  • Because MOFs are completely new inorganicorganic hybrid self-organized porous materials, the chemical industry has recently been highly focused on them.
  • The conventional porous materials such as zeolite, activated carbon, and porous silica have been used as catalysts, separators, adsorbents, impurity removers for water, and deodorizing materials.