Risk

Type 2 diabetes is not one-size-fits-all: Subtypes affect complications and treatment options

Retrieved on: 
Friday, April 19, 2024

You may have heard of Ozempic, the “miracle drug” for weight loss, but did you know that it was actually designed as a new treatment to manage diabetes?

Key Points: 
  • You may have heard of Ozempic, the “miracle drug” for weight loss, but did you know that it was actually designed as a new treatment to manage diabetes?
  • In Canada, diabetes affects approximately 10 per cent of the general population.

Locks and keys

  • Every cell in the body needs sugar as an energy source, but too much sugar can be toxic to cells.
  • This equilibrium needs to be tightly controlled and is regulated by a lock and key system.
  • Cells cover themselves with locks that respond perfectly to insulin keys to facilitate the entry of sugar into cells.
  • The body can encounter difficulties producing an adequate number of insulin keys, and/or the locks can become stubborn and unresponsive to insulin.

Severe insulin-deficient diabetes: We’re missing keys!

  • In the severe insulin-deficient diabetes (SIDD) subtype, the key factories — the beta cells — are on strike.
  • Why the beta cells go on strike remains largely unknown, but since there is an insulin deficiency, treatment often involves insulin injections.

Severe insulin-resistant diabetes: But it’s always locked!

  • In the severe insulin-resistant diabetes (SIRD) subtype, the locks are overstimulated and start ignoring the keys.
  • There are many treatment avenues for these patients but no consensus about the optimal approach; patients often require high doses of insulin.

Mild obesity-related diabetes: The locks are sticky!

  • Mild obesity-related (MOD) diabetes represents a nuanced aspect of Type 2 diabetes, often observed in individuals with higher body weight.
  • The locks are “sticky,” so it is challenging for the key to click in place and open the lock.

Mild age-related diabetes: I’m tired of controlling blood sugar!


Mild age-related diabetes (MARD) happens more often in older people and typically starts later in life. With time, the key factory is not as productive, and the locks become stubborn. People with MARD find it tricky to manage their blood sugar, but it usually doesn’t lead to severe complications. Among the different subtypes of diabetes, MARD is the most common.

Unique locks, varied keys

  • In Canada, unique cases of Type 2 diabetes were identified in Indigenous children from Northern Manitoba and Northwestern Ontario by Dr. Heather Dean and colleagues in the 1980s and 90s.
  • Read more:
    Indigenous community research partnerships can help address health inequities

    Childhood-onset Type 2 diabetes is on the rise across Canada, but disproportionately affects Indigenous youth.

  • Acknowledging this distinct subtype of Type 2 diabetes in First Nations communities has led to the implementation of a community-based health action plan aimed at addressing the unique challenges faced by Indigenous Peoples.

A mosaic of conditions

  • Type 2 diabetes is not uniform; it’s a mosaic of conditions, each with its own characteristics.
  • Since diabetes presents so uniquely in every patient, even categorizing into subtypes does not guarantee how the disease will evolve.


Lili Grieco-St-Pierre receives funding from Fonds de recherche du Québec - Santé (FRQS). Jennifer Bruin receives funding from the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), JDRF, Diabetes Canada.

Many prisoners go years without touching a smartphone. It means they struggle to navigate life on the outside

Retrieved on: 
Friday, April 19, 2024

You’d be hard pressed to find any aspect of daily life that doesn’t require some form of digital literacy.

Key Points: 
  • You’d be hard pressed to find any aspect of daily life that doesn’t require some form of digital literacy.
  • We need only to look back ten years to realise how quickly things have changed.
  • In 2013, we were still predominantly buying paper bus tickets and using Facebook on a desktop computer.

Unfamiliar tech damaging confidence


Prison populations are getting older worldwide for a few reasons, including general population ageing, trends towards people entering prison at an older age, or staying in for longer. At the same time, Australian prisons remain highly technologically restricted environments, mostly for security reasons. We interviewed 15 Australians (aged 47–69 years) about their experiences of reintegration following release from prison.

  • They described feeling like a stranger thrown into a world where survival depended on their ability to use technology.
  • Regardless of their experiences before imprisonment, the rapid digitisation of daily functions that were once familiar to them rendered their skills and confidence irrelevant.
  • One former inmate said:
    There’s a significant gap […] for anybody who’s done, I’m gonna say, probably more than five to seven years [in prison].
  • There’s a significant gap […] for anybody who’s done, I’m gonna say, probably more than five to seven years [in prison].

Exacerbating recidivism

  • There’s concerning evidence around recidivism, risk of post-release mortality, social isolation, unemployment and homelessness.
  • Digital exclusion creates an additional barrier for those who are older, who already face a high risk of medical and social marginalisation.
  • A former prisoner said:
    Think about it, after being in ten years, well you think, okay, where do I start?

What can be done?

  • The interviewees provided suggestions for how such programs could be delivered and a keenness to engage with them.
  • They tended to focus on learning in environments free from stigma and judgement of their literacy level or histories, with hands-on experience and face to face support.
  • Interviewees favoured learning while in prison, with additional support available on the outside.
  • Based on the evidence, we can be certain this will encourage positive change for the 95% of Australian prisoners who will eventually be released.


Ye In (Jane) Hwang has received funding from the National Health and Medical Research Council of Australia, the Australian Association of Gerontology, and the University of New South Wales Ageing Futures Institute for this work.

Good news: midlife health is about more than a waist measurement. Here’s why

Retrieved on: 
Friday, April 19, 2024

During the appointment they measure your waist.

Key Points: 
  • During the appointment they measure your waist.
  • GPs and health professionals commonly measure waist circumference as a vital sign for health.
  • Men are at greatly increased risk of health issues if their waist circumference is greater than 102 centimetres.
  • More than two-thirds of Australian adults have waist measurements that put them at an increased risk of disease.

How much is too much?

  • A ratio of 0.6 or more places a person at the highest risk of disease.
  • This can kick off a discussion about their risk of chronic diseases and how they might address this.
  • For women, hormone levels begin changing in mid-life and this also stimulates increased fat levels particularly around the abdomen.
  • Finally, your family history and genetics can make you predisposed to gaining more abdominal fat.

Why the waist?

  • Visceral fat surrounds and infiltrates major organs such as the liver, pancreas and intestines, releasing a variety of chemicals (hormones, inflammatory signals, and fatty acids).
  • These affect inflammation, lipid metabolism, cholesterol levels and insulin resistance, contributing to the development of chronic illnesses.
  • In addition to the direct effects of hormone changes, declining levels of oestrogen change brain function, mood and motivation.
  • These psychological alterations can result in reduced physical activity and increased eating – often of comfort foods high in sugar and fat.
  • And importantly, the waist circumference (and ratio to height) is just one measure of human health.

Muscle matters

  • On current evidence, it is equally or more important for health and longevity to have higher muscle mass and better cardiorespiratory (aerobic) fitness than waist circumference within the healthy range.
  • So, if a person does have an excessive waist circumference, but they are also sedentary and have less muscle mass and aerobic fitness, then the recommendation would be to focus on an appropriate exercise program.
  • Conversely, a person with low visceral fat levels is not necessarily fit and healthy and may have quite poor aerobic fitness, muscle mass, and strength.

Getting moving is important advice

  • Exercise can counter a lot of the negative behavioural and physiological changes that are occurring during midlife including for people going through menopause.
  • And regular exercise reduces the tendency to use food and drink to help manage what can be a quite difficult time in life.
  • Measuring your waist circumference and monitoring your weight remains important.


Rob Newton receives funding from National Health and Medical Research Council, the Medical Research Future Fund, Cancer Council Western Australia, Spinal Cord Injuries Australia and the World Cancer Research Fund. Rob Newton is a board member of The Healthy Male.

Are 2 mid-career AFL retirements a sign Australian athletes are taking brain health more seriously?

Retrieved on: 
Friday, April 19, 2024

The 24-year-old’s seemingly sudden retirement, following Angus Brayshaw’s in February and a number of other high-profile footballers in recent years, signals a shift in how athletes view brain trauma risks in sport.

Key Points: 
  • The 24-year-old’s seemingly sudden retirement, following Angus Brayshaw’s in February and a number of other high-profile footballers in recent years, signals a shift in how athletes view brain trauma risks in sport.
  • Rather than downplaying or ignoring the potential damage being done to their health by a career filled with brain trauma, some athletes are now choosing to end their careers early.

Why do athletes risk their brains?

  • For decades, sports have fostered a win-at-all-costs culture, with a pseudo-military flavour of sacrifice and duty to one’s teammates.
  • This has given rise to athletes ignoring or downplaying injuries whenever possible to continue the game.
  • Media commentators also celebrate athletes who return to the field after sickening collisions as “courageous”, having “no fear”, or “gaining respect from teammates and opposition”.

A shift in attitude?

  • Murphy’s retirement and acknowledgement of his long-term brain health is one sign the culture of valorising injury and risk may be changing.
  • But there is other evidence of a shift.
  • Australian research shows risky attitudes and behaviours toward concussion have begun to dissipate over recent years.
  • However, a 2021 follow-up study, using the same survey in a separate group, showed significant improvements towards concussion.

Are more retirements to come?

  • In the meantime, the current group of athletes – professionals and amateurs alike – must weigh up the costs of participation in high contact games.
  • It’s in the best interests for the longevity of these sports – and the athletes we love to cheer on.
  • Alan is a non-executive unpaid director for the Concussion Legacy Foundation.
  • He has previously received funding from Erasmus+ strategic partnerships program (2019-1-IE01-KA202-051555), Sports Health Check Charity (Australia), Australian Football League, Impact Technologies Inc., and Samsung Corporation, and is remunerated for expert advice to medico-legal practices.

‘It could be the death of the museum’: why research cuts at a South Australian institution have scientists up in arms

Retrieved on: 
Friday, April 19, 2024

“It could be the death of the museum,” says renowned mammalogist Tim Flannery, a former director of the museum.

Key Points: 
  • “It could be the death of the museum,” says renowned mammalogist Tim Flannery, a former director of the museum.
  • “To say research isn’t important to what a museum does – it’s sending shock waves across the world,” she says.

What’s the plan?

  • According to the museum’s website, this skeleton crew will focus on “converting new discoveries and research into the visitor experience”.
  • Others have tackled global questions such as the evolution of birds from dinosaurs, how eyes evolved in Cambrian fossils, and Antarctic biodiversity.

What’s so special about a museum?

  • Their remits are different, says University of Adelaide botanist Andy Lowe, who was the museum’s acting director in 2013 and 2014.
  • Unlike universities, he says, the museum was “established by government, to carry out science for the development of the state”.
  • “They’re crucial for what goes on above; you need experts not second-hand translators,” says University of Adelaide geologist Alan Collins.
  • He wonders what will happen the next time a youngster comes into the museum asking to identify a rock.
  • The museum’s Phillip Jones now uses this collection in his research, delivering more than 30 exhibitions, books and academic papers.

Continuity and community

  • Without attentive curation and the life blood of research, the collections are doomed to “wither and die”, says Flannery.
  • That raises the issue of continuity.
  • In Flannery’s words, the job of a museum curator:
    is like being a high priest in a temple.
  • Over Jones’ four decades at the museum, his relationships with Indigenous elders have also been critical to returning sacred objects to their traditional owners.
  • Besides the priestly “chain of care”, there’s something else at risk in the museum netherworld: a uniquely productive ecosystem feeding on the collections.
  • Here you’ll find PhD students mingling with retired academics; curators mingling with scientists; museum folk with university folk.
  • In the year ending 2023 for instance, joint museum and university grants amounted to A$3.7 million.

DNA and biodiversity

  • The museum has also declared it will no longer support a DNA sequencing lab it funds jointly with the University of Adelaide.
  • “No other institute in South Australia does this type of biodiversity research,” says Andrew Austin, chair of Taxonomy Australia and emeritus professor at the University of Adelaide.
  • “It’s the job of the museum.” The cuts come while the SA government plans new laws to protect biodiversity.


Elizabeth Finkel does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

In Knife, his memoir of surviving attack, Salman Rushdie confronts a world where liberal principles like free speech are old-fashioned

Retrieved on: 
Friday, April 19, 2024

A man named Hadi Matar has been charged with second-degree attempted murder.

Key Points: 
  • A man named Hadi Matar has been charged with second-degree attempted murder.
  • He is an American-born resident of New Jersey in his early twenties, whose parents emigrated from Lebanon.
  • Review: Knife: Meditations After an Attempted Murder – Salman Rushdie (Jonathan Cape) Knife is very good at recalling Rushdie’s grim memories of the attack.
  • “Let me offer this piece of advice to you, gentle reader,” he says: “if you can avoid having your eyelid sewn shut … avoid it.
  • Here, for a number of reasons, Rushdie is not on such secure ground.
  • Read more:
    How Salman Rushdie has been a scapegoat for complex historical differences

    Rushdie, who studied history at Cambridge University, described himself in Joseph Anton as “a historian by training”.

  • Indeed, a speech he gave at PEN America in 2022 is reprinted in the book verbatim.
  • For these intellectuals, principles of secular reason and personal liberty should always supersede blind conformity to social or religious authority.

Old-fashioned liberal principles

  • In Knife, though, Rushdie the protagonist confronts a world where such liberal principles now appear old-fashioned.
  • He claims “the groupthink of radical Islam” has been shaped by “the groupthink-manufacturing giants, YouTube, Facebook, Twitter”.
  • But for many non-religious younger people, any notion of free choice also appears illusory, the anachronistic residue of an earlier age.
  • Millennials and Generation Z are concerned primarily with issues of environmental catastrophe and social justice, and they tend to regard liberal individualism as both ineffective and self-indulgent.
  • A new book traces how we got here, but lets neoliberal ideologues off the hook

Suffused in the culture of Islam

  • The Satanic Verses itself is suffused in the culture of Islam as much as James Joyce’s Ulysses is suffused in the culture of Catholicism.
  • In their hypothetical conversation, the author of Knife tries to convince his assailant of the value of such ambivalence.
  • He protests how his notorious novel revolves around “an East London Indian family running a café-restaurant, portrayed with real love”.

Attachment to past traditions

  • Rushdie discusses in Knife how, besides the Hindu legends of his youth, he has also been “more influenced by the Christian world than I realized”.
  • He cites the music of Handel and the art of Michelangelo as particular influences.
  • Yet this again highlights Rushdie’s attachments to traditions firmly rooted in the past.
  • Part of James’s greatness lay in the way he was able to accommodate these radical shifts within his writing.

‘A curiously one-eyed book’

  • Particularly striking are the immediacy with which he recalls the shocking assault, the black humour with which he relates medical procedures and the sense of “exhilaration” at finally returning home with his wife to Manhattan.
  • Yet there are also many loose ends, and the book’s conclusion, that the assailant has in the end become “simply irrelevant” to him, is implausible.
  • He insists he does not want to write “frightened” or “revenge” books.
  • This was despite several brave comeback attempts by Milburn that likewise cited Pataudi as an example.
  • Knife, by contrast, is a curiously one-eyed book, in a metaphorical, as well as a literal sense.


Paul Giles does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Caring for older Americans’ teeth and gums is essential, but Medicare generally doesn’t cover that cost

Retrieved on: 
Friday, April 19, 2024

As dentistry scholars, we believe Koop also deserves credit for something else.

Key Points: 
  • As dentistry scholars, we believe Koop also deserves credit for something else.
  • Americans who rely on the traditional Medicare program for their health insurance get no help from that program with paying their dental bills aside from some narrow exceptions.
  • This group includes some 24 million people over 65 – about half of all the people who rely on Medicare for their health insurance.

‘Medically necessary’ exceptions

  • The list of circumstances that would lead patients to be eligible is short.
  • Some examples include patients scheduled for organ transplants or who have cancer treatment requiring radiation of their jaws.
  • But we believe that dental care is necessary for everyone, especially for older people.

Chew, speak, breathe

  • While many working Americans get limited dental coverage through their employers, those benefits are usually limited to as little as $1,000 per year.
  • And once they retire, Americans almost always lose even that basic coverage.
  • Rich Americans with Medicare coverage are almost three times more likely to receive dental care compared to those with low incomes.

Connected to many serious conditions

  • Having diabetes makes you three times as likely to develop gum disease because diabetes compromises the body’s response to inflammation and infection.
  • At the same time, treating diabetes patients for gum disease can help control their blood sugar levels.

Chemo can damage your teeth


Many cancer treatments can damage teeth, especially for older adults. As a result, Medicare has started to reimburse for dental bills tied to tooth decay or other oral conditions after they get chemotherapy or radiation treatment.

More than nice to have

  • Doctors and dentists are educated separately, and doctors learn very little about dental conditions and treatments when they’re in medical school.
  • Most dental electronic health records aren’t linked to medical systems, hindering comprehensive care and delivery of dental care to those in need.
  • Medical insurance was designed specifically to cover large, unpredictable expenses, while dental insurance was intended to mainly fund predictable and lower-cost preventive care.

Medicare Advantage plans

  • Until Medicare expands coverage to include preventive dental services for everyone, alternative plans such as Medicare Advantage, through which the federal government contracts with private insurers to provide Medicare benefits, serve as a stopgap.
  • In 2016, only 21% of beneficiaries in traditional Medicare had purchased a stand-alone dental plan, whereas roughly two-thirds of Medicare Advantage enrollees had at least some dental benefits through their coverage.


Frank Scannapieco is affiliated with The Task Force on Design and Analysis in Oral Health Research, and consults for the Colgate-Palmolive Company. Ira Lamster is a member of the Santa Fe Group. He currently receives consulting fees from Colgate, and research support from the CareQuest Institute.

Liz Truss: an economist explains what she got wrong (and what she’s actually right about)

Retrieved on: 
Friday, April 19, 2024

Busy promoting her new memoir, she has dismissed anyone who blames her for crashing the UK economy as “stupid or malevolent”.

Key Points: 
  • Busy promoting her new memoir, she has dismissed anyone who blames her for crashing the UK economy as “stupid or malevolent”.
  • But Truss knew the institutional context she was working in, and everything that happened after the mini-budget was entirely predictable.
  • She made a big mistake that affected millions of ordinary people, and has only herself to blame.
  • For while these constraints are generally beneficial to the economy, they also make it almost impossible to develop a radical agenda.
  • And, in a country suffering from massive underinvestment in the public sector, there may be a case for greater flexibility.

Fiscal frustration

  • But fiscal targets have their problems too.
  • And thanks to fiscal targets, subsequent governments have repeatedly cut investment in infrastructure.
  • The Labour Party has already said it will not make ambitious spending plans which might risk the credibility of its fiscal policy should it win the next election.
  • Yet fiscal credibility and major investment are not mutually exclusive everywhere.


Renaud Foucart does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Domestic politics will be a key factor in how far things escalate between Israel and Iran

Retrieved on: 
Friday, April 19, 2024

Following Iran’s barrage of drone and missile attacks on April 13, Israel has retaliated and conducted a strike attack near the city of Isfahan in southern Iran.

Key Points: 
  • Following Iran’s barrage of drone and missile attacks on April 13, Israel has retaliated and conducted a strike attack near the city of Isfahan in southern Iran.
  • Both sides have now matched each other in striking targets within each other’s national border.
  • However, details of the extent of any damage done by Israel’s strike are disputed and are being played down by Iran.

The politics of status

  • Domestic issues can play an important role here, in how the political and military elites of both states decide to react.
  • Despite the majority of the Israeli public being in favour of the campaign to eradicate Hamas in Gaza, he remains unpopular.
  • Hence there are good reasons for him to respond military to the challenge posed by Iran.

Regime forged in war

  • Historically, the trauma of war has been used by the Islamic Republic to foster nationalism among the population.
  • Following the Iran-Iraq war in the 1980s, the loss of Iranian life, which totalled in the hundreds of thousands, played a huge role in cementing “the formation and empowerment of the Islamic Republic”.
  • Militarily contesting Israel can be perceived as a means of solidifying the regime’s position internally and enhancing the country’s image within the region.
  • At present, neither side has the ability to send an expeditionary force into each other’s territory.


Ben Soodavar does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Why you shouldn’t be afraid to start running after middle age

Retrieved on: 
Friday, April 19, 2024

As someone who started marathon running in mid-life, I know how many aches and pains (and doubts) you can have if you take on the challenge to start running at an older age.

Key Points: 
  • As someone who started marathon running in mid-life, I know how many aches and pains (and doubts) you can have if you take on the challenge to start running at an older age.
  • Hobbling around my orthopaedic hospital after my first marathon actually led me to do research on runners.
  • The high-resolution MRI scans found most of the 115 middle-aged participants had abnormalities in their knees before starting marathon training.
  • But while osteoarthritis is more common after middle age, it may actually be a lack of activity that leads to osteoarthritis.
  • Reduced muscle use, whether it is through inactivity or sarcopenia or both, also reduces the production of anti-inflammatory myokines from the muscles.
  • These chemicals are released when we exercise, and help reduce joint swelling and calm irritated joint linings.
  • This effect is pronounced in runners because running uses some of the largest muscles in the body – such as the glutes, quadriceps and hamstrings.

Where to begin

  • If you want to start running, the main message is to ease into it to reduce the risk of injury.
  • One of the best ways to ease into running in mid-life is the NHS Couch to 5K running programme.
  • It’s a free guide that will help you gradually work up towards running 5km in just nine weeks.
  • If you’ve experienced any of these problems, you’ll want to be careful when exercising to avoid further damage.


Alister Hart receives funding from 3 charities: The Rosetrees Trust, Arthroplasty for Arthritis and The Maurice Hatter Foundation.