DNA damage (naturally occurring)

Indian Researchers from ACTREC Discover Novel Therapeutic Agent for a Host of Diseases

Retrieved on: 
Tuesday, January 17, 2023
Neurodegeneration, Cell, Fatality, Atomic energy, Metastasis, DNA damage (naturally occurring), Chromosome, Chromatin, Cytokine, Acral lentiginous melanoma, DNA, Copper, Resveratrol, Surgical oncology, Diarrhea, Treatment, Copper toxicity, Genetically modified bacteria, Emeritus, DNA repair, Protein, Patient, Saliva, Sepsis, Mouse, Bone marrow, Transplant, Research, Vomiting, Serum, Tata Memorial Centre, Inflammation, Incidence, Alzheimer's disease, RESCU, Department of Atomic Energy, ACTREC, Docetaxel, Translational research, Vaccine, TMC, Cancer

MUMBAI, India, Jan. 17, 2023 /PRNewswire/ -- Chromatin comprises a complex mixture of DNA and proteins and forms the structural basis of chromosomes in the cellular nuclei. When cells die, they release cell-free chromatin particles or "cfChPs" into the circulatory system. Emerging evidence indicates that cfChPs exert toxic effects by damaging the DNA of healthy cells and activating pro-inflammatory processes. Researchers from the Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre (TMC), India, have recently demonstrated therapeutic benefits of a pro-oxidant mixture of resveratrol and copper, R-Cu, in patients undergoing chemotherapy for advanced gastric cancer. Combining R with Cu (R-Cu) leads to the generation of free oxygen radicals which can inactivate the offending cfChPs.

Key Points: 
  • When cells die, they release cell-free chromatin particles or "cfChPs" into the circulatory system.
  • Emerging evidence indicates that cfChPs exert toxic effects by damaging the DNA of healthy cells and activating pro-inflammatory processes.
  • Researchers from the Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre (TMC), India, have recently demonstrated therapeutic benefits of a pro-oxidant mixture of resveratrol and copper, R-Cu, in patients undergoing chemotherapy for advanced gastric cancer .
  • Combining R with Cu (R-Cu) leads to the generation of free oxygen radicals which can inactivate the offending cfChPs.