FGL2

Ozone and PM2.5 Exposure is Associated with Nasal Key Driver Gene Expression in People with Asthma

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Thursday, February 15, 2024
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MILWAUKEE, Feb. 15, 2024 /PRNewswire-PRWeb/ -- Nasal key driver gene expression representing T-cell mediated immune processes is associated with ozone and fine particulate matter (PM2.5) exposure in people with asthma according to new research being presented at the 2024 American Academy of Allergy, Asthma & Immunology Annual Meeting.

Key Points: 
  • MILWAUKEE, Feb. 15, 2024 /PRNewswire-PRWeb/ -- Nasal key driver gene expression representing T-cell mediated immune processes is associated with ozone and fine particulate matter (PM2.5) exposure in people with asthma according to new research being presented at the 2024 American Academy of Allergy, Asthma & Immunology Annual Meeting.
  • In the study, researchers identified six key driver genes for ozone and three key driver genes for PM2.5 exposure.
  • FGL2, previously reported as a master regulator of asthma, was the most upstream key driver for both ozone and PM2.5.
  • The findings suggest exposure to ozone and PM2.5 in individuals with asthma is associated with nasal key driver gene expression representing T-cell mediated immune processes.