Blacksmith

Blacksmith Medicines To Highlight Preclinical Oncology Data Demonstrating a Potent and Selective FEN1 Inhibitor Has Synergy with Multiple DDR Drug Classes at AACR Annual Meeting 2024

Retrieved on: 
Wednesday, April 10, 2024
DNA replication, PARP1, Olaparib, PARG, CRISPR, PARP, HR, IC50, ADME, DNA, Chromatin, PDD, San Diego Convention Center, FEN1, DNA repair, DDR, EC50, Blacksmith, Niraparib, Erosion (morphology), AACR, ATR, Drug discovery, USP1, SAN, Pharmaceutical industry

"Using our metalloenzyme fragment-based drug discovery approach, we have identified a highly potent and selective inhibitor of FEN1 having synergies with multiple DDR drug classes that include inhibitors of PARP, PARG, USP1, and ATR."

Key Points: 
  • "Using our metalloenzyme fragment-based drug discovery approach, we have identified a highly potent and selective inhibitor of FEN1 having synergies with multiple DDR drug classes that include inhibitors of PARP, PARG, USP1, and ATR."
  • The Blacksmith fragment-based drug discovery platform identified a novel metal-binding pharmacophore that binds to the two magnesium ions in the FEN1 active site.
  • Further elaboration using fragment growth strategies resulted in highly potent and selective inhibitors.
  • Title: "Small molecule inhibitor of FEN1 nuclease utilizing a novel metal binding pharmacophore synergizes with inhibitors of USP1, PARP, PARG and ATR"

EBRD and Erste Approve Financing for the Pupin Windfarm in Serbia

Retrieved on: 
Wednesday, March 27, 2024
Electricity, Economy, European Central Bank, Coal, Reconstruction, Policy, Sale, Blacksmith, Wind, Carbon, Corporate finance, Enlight Renewable Energy, EBRD, TEL, State, Renewable energy

TEL AVIV, Israel, March 27, 2024 (GLOBE NEWSWIRE) -- Enlight Renewable Energy (“Enlight”) (NASDAQ: ENLT, TASE: ENLT), a leading global renewable energy platform, today announced The European Bank for Reconstruction and Development (EBRD), together with Erste Group Bank AG and its local bank Erste Bank a.d. Novi Sad (Erste), have approved a financing package worth $101 million for the construction of a new windfarm in Serbia, which will be built by Enlight. The financing package will provide a major boost to the country’s goal of diversifying its energy mix.

Key Points: 
  • The financing package will provide a major boost to the country’s goal of diversifying its energy mix.
  • The EBRD and Erste will provide parallel loans, worth $50.5 million each, including the associated debt service reserve facilities.
  • The Pupin project is expected to begin operating commercially in the second half of 2025.
  • The windfarm will also help to reduce the carbon intensity of Serbia’s power sector and advance its green economy transition.

Blacksmith Medicines to Present at the 23rd Annual Needham Healthcare Conference

Retrieved on: 
Wednesday, April 3, 2024
SAN, Conference, Blacksmith, Pharmaceutical industry

SAN DIEGO, April 3, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, today announced that it will present a company overview and participate in 1x1 meetings at the 23rd Annual Needham Healthcare Conference on Thursday, April 11, 2024 at 11:00 am ET.

Key Points: 
  • SAN DIEGO, April 3, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, today announced that it will present a company overview and participate in 1x1 meetings at the 23rd Annual Needham Healthcare Conference on Thursday, April 11, 2024 at 11:00 am ET.
  • "At Blacksmith Medicines, we are developing a pipeline of novel small molecule medicines targeting metalloenzymes of significant unmet need and high pharma interest, but chemistry limitations have hampered previous efforts that we can solve using our technology platform," said Zachary A. Zimmerman, Ph.D., CEO of Blacksmith.
  • "We look forward to presenting our story at the Needham conference and showcasing the vast number of important metalloenzyme targets, the broad therapeutic application of our technology, and our compelling preclinical data."

Lights, Camera, Britain! Transport Yourself into Your Favorite Films & TV Shows

Retrieved on: 
Thursday, March 28, 2024
Steps, Season, Gentleman, Grantley Hall, Travel, History, Blacksmith, Hampton Court Palace, Duke, Amy, Television, Primrose Hill, Doctor, Outlander, Invisibility, Back to Black, Hatfield House, Tourism, Harry Potter, Fitzroy Square, Royal Mile, Doctor Who, Invisible Cities, The Gentlemen (2019 film), Ted Lasso, National Museum Cardiff, VisitBritain, Valley Railway, Bamburgh Castle, The Fast Show, Ronnie Scott, Metropolis Group, Culture, Edinburgh Castle, Netflix, Walking, Great Britain, Expedia, Wales Coast Path, Royal Crescent, Life, Sensation, Multimedia, Camden Market, Charlotte of Mecklenburg-Strelitz, Amy Winehouse

Visit Grassmarket and walk up the Vennel Steps, where Dexter chases down Emma, for an incredible view of Edinburgh Castle .

Key Points: 

Blacksmith Medicines Announces Upcoming Presentation at AACR Annual Meeting 2024

Retrieved on: 
Wednesday, March 6, 2024
SAN, PARG, San Diego Convention Center, Blacksmith, FEN1, USP1, AACR, ATR, PARP, Pharmaceutical industry

SAN DIEGO, March 6, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, today announced the company will present data on its oncology program targeting flap endonuclease 1 (FEN1), a structure-specific metallonuclease that cleaves 5' DNA flaps during replication and repair, at the American Association for Cancer Research (AACR) Annual Meeting 2024, taking place April 5-10 at the San Diego Convention Center, San Diego CA.

Key Points: 
  • SAN DIEGO, March 6, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, today announced the company will present data on its oncology program targeting flap endonuclease 1 (FEN1), a structure-specific metallonuclease that cleaves 5' DNA flaps during replication and repair, at the American Association for Cancer Research (AACR) Annual Meeting 2024, taking place April 5-10 at the San Diego Convention Center, San Diego CA.
  • Details of the poster presentation are as follows:
    Title: "Small molecule inhibitor of FEN1 nuclease utilizing a novel metal binding pharmacophore synergizes with inhibitors of USP1, PARP, PARG and ATR"

Blacksmith Medicines and Zoetis Announce Research Collaboration for Novel Animal Health Antibiotics

Retrieved on: 
Wednesday, February 14, 2024
FDA, SAN, Health, Collection, Animal, Bacteria, EMA, CDC, WOAH, Blacksmith, WHO, Livestock, Research, Human, Pharmaceutical industry

SAN DIEGO, Feb. 14, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, and Zoetis, the world's leading animal health company, announced today a collaboration to discover and develop novel antibiotics for animal health.

Key Points: 
  • SAN DIEGO, Feb. 14, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, and Zoetis, the world's leading animal health company, announced today a collaboration to discover and develop novel antibiotics for animal health.
  • Blacksmith and Zoetis will collaborate to discover and develop novel antibiotics to selectively target bacteria for animal health," said Zachary Zimmerman, Ph.D., CEO and co-founder of Blacksmith.
  • "As part of our commitment to reduce the dependency on antibiotic classes shared with human health, we are pleased to leverage our veterinary expertise along with our extensive collection of pathogens in this collaboration with Blacksmith," said Dr. Jeff Watts, Research Director, External Innovation at Zoetis.
  • "Through our research, we aim to ultimately provide new options for our customers to treat life-threatening infections in livestock."

Encompass Corporation acquires CoorpID and Blacksmith KYC from ING to develop revolutionary Corporate Digital Identity platform

Retrieved on: 
Tuesday, January 16, 2024
KYC, ING, CDD, Heart, FEC, Ecosystem, CLM, Risk, Sale, CDI, Acquisition, Blacksmith, Finance, Encompass, Digital

In 2018, CoorpID was founded by ING Labs in response to complex KYC challenges ING and the wider market faced.

Key Points: 
  • In 2018, CoorpID was founded by ING Labs in response to complex KYC challenges ING and the wider market faced.
  • CoorpID enables Encompass to build a complete KYC profile, combining authoritative public information with private information directly from customers.
  • The deal will see Encompass acquire 100% of CoorpID and Blacksmith, creating a platform that will transform the KYC process across the industry.
  • "ING's commitment to supporting and fuelling KYC excellence has led to the successful journeys of CoorpID and Blacksmith KYC.

Defense Derby’s January Update Brings New Blacksmith Unit

Retrieved on: 
Friday, December 29, 2023
Entertainment, Apps, Applications, Technology, Online, Mobile Entertainment, Software, Electronic Games, Blacksmith, Multimedia, Forge, Divinity, Christmas, Social media, Hannah Marks, Shop, PvP

RisingWings , a creative studio of KRAFTON, Inc. , released its January update for the popular real-time PvP tower defense mobile game, Defense Derby .

Key Points: 
  • RisingWings , a creative studio of KRAFTON, Inc. , released its January update for the popular real-time PvP tower defense mobile game, Defense Derby .
  • View the full release here: https://www.businesswire.com/news/home/20231228541981/en/
    Defense Derby reveals the Blacksmith unit on the January update (Graphic: KRAFTON, Inc.)
    This update brings in the Blacksmith, a new physical-type human faction unit.
  • As a splash damage unit, the Blacksmith excels against groups of monsters and provides valuable support to heroes.
  • The Derby Brawl - Blacksmith Mirror Match, featuring this new unit, is available until January 11.

NantGames Announces Studio’s First Mobile Game, MythWalker™

Retrieved on: 
Monday, November 13, 2023
Entertainment, Consumer Electronics, Apps, Applications, Technology, Mobile Entertainment, Software, Electronic Games, Weapon, Android, Priest, Mining, Blacksmith, Gemstone, Heliopolis (ancient Egypt), RPG, Lead, Warrior, IOS, Video game, Hyport Duqm, Child

NantGames is excited to announce MythWalker, the first title developed and published by this new game studio.

Key Points: 
  • NantGames is excited to announce MythWalker, the first title developed and published by this new game studio.
  • MythWalker is a unique geolocation fantasy RPG which will be released on iOS and Android devices.
  • A closed beta will be available starting November 15 in Australia, with other regions being added throughout 2024.
  • The first chapter of a memorable story and journey:
    This closed Beta will allow players access to explore a variety of gameplay features.

Defense Derby's November Update: New Heroes Join the Fray!

Retrieved on: 
Wednesday, November 8, 2023
Entertainment, Consumer Electronics, Technology, Mobile Entertainment, Mobile, Wireless, Software, Electronic Games, Gems, Mission, Social media, Player versus environment, Time for the Moon Night (song), Gemstone, Multimedia, Hot Time/A. (Answer), Hannah Marks, Lana, Shop, Noah Great Voyage in Fukuoka 2022, Blacksmith, Graphics, PvP, Stick, Finesse, Rake, Cubic Corporation, Satellite navigation device

RisingWings , an independent studio of KRAFTON, Inc. , unveiled its November update for the popular real-time PvP tower defense mobile game, Defense Derby .

Key Points: 
  • RisingWings , an independent studio of KRAFTON, Inc. , unveiled its November update for the popular real-time PvP tower defense mobile game, Defense Derby .
  • View the full release here: https://www.businesswire.com/news/home/20231107202290/en/
    Defense Derby, a popular real-time PvP tower defense mobile game, unveils 3 new heroes on its November update (Graphic: KRAFTON)
    This update spotlights three new heroes, kicking off with Rake, a beast faction magic wielder who enhances allied damage against common monsters.
  • Her signature Chain of Hatred skill incapacitates two enemy units, preventing their deployment and attacks for a time.
  • For the latest Defense Derby updates, please visit https://www.facebook.com/DefenseDerby.THAILAND and follow along on social media ( YouTube | Discord ).