Squamous intraepithelial lesion

Breakthrough in Treatment of Cervical High-Grade Squamous Intraepithelial Lesion: Release of Positive Results from Multicenter Phase III Global Clinical Study

Retrieved on: 
Tuesday, March 19, 2024
Medicine, Cervical cancer, Patient, Cancer, HPV16, School, Congress, Gynaecology, Risk, Peking Union Medical College, Woman, LEEP, Safety, Gynecologic Oncology (journal), Pathology, Recurrence, Squamous intraepithelial lesion, Acceleration, Research, Șaeș, SGO, Death, National Cancer Center, Vaccination, Molina Healthcare, Annual general meeting, Health, Obstetrics, Hysterectomy, HSIL, Public health, Infection, Incidence, LSIL, HPV, Bleeding, Physician, Birth control

This study is a prospective, randomized, double-blinded, placebo-controlled multicenter Phase III global clinical study designed to evaluate the efficacy and safety of APL-1702 for the treatment of cervical HSIL.

Key Points: 
  • This study is a prospective, randomized, double-blinded, placebo-controlled multicenter Phase III global clinical study designed to evaluate the efficacy and safety of APL-1702 for the treatment of cervical HSIL.
  • Primary endpoint of the study is the proportion of responders at 6 months after the initial treatment.
  • The study is led by Dr. Jinghe Lang, an academician at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences.
  • Dr. Linda Wu, Chief Development Officer of Asieris Pharmaceuticals, said, "We are extremely proud of the results from the international multicenter Phase III clinical study of APL-1702.

uBiome Awards Grant to UCSF Researchers to Study Association Between Anal Microbiome Composition and Anal Cancer

Retrieved on: 
Tuesday, January 29, 2019
Cancer, Infectious causes of cancer, Microorganisms, Branches of biology, Papillomavirus, Bacteriology, Microbiology, Gastrointestinal cancer, Anal cancer, Human papillomavirus infection, Microbiota, Squamous intraepithelial lesion

The goal of the study is to evaluate the association between the microbiome and anal cancer precursors among individuals at the highest risk for malignancy: HIV-infected men who have sex with men (MSM) with anal HPV-16 infection.

Key Points: 
  • The goal of the study is to evaluate the association between the microbiome and anal cancer precursors among individuals at the highest risk for malignancy: HIV-infected men who have sex with men (MSM) with anal HPV-16 infection.
  • The researchers plan to characterize the differences in microbiome richness and variability of the anal microbiome in men with and without anal high-grade squamous intraepithelial lesions (HSIL).
  • Data collected from the study will include microbiome composition from uBiome's patented kits, anal microbiome composition, and community richness and evenness of both sites to capture total community diversity.
  • This will be one of the first studies to examine the role of the anal microbiome in anal cancer pathogenesis."