Optical mapping

Global Cytogenetics Markets, Technology, & Competitive Landscape Report 2021 with Profiles of 70 Companies - ResearchAndMarkets.com

Retrieved on: 
Thursday, November 18, 2021
Technology, Biotechnology, Nanotechnology, Health, CGH, Chromosome, Fort Dix, Single-nucleotide polymorphism, Optical flow, Technology, Magnetic resonance imaging, Biomarker, FISH, PCR, Diagnosis, Disease, SWOT, Nanotechnology, Cancer, SPM, AFM, Human, Fluorescence, Therapy, PNA, Genetic variation, Molecular imaging, Lists of diseases, Hybridization probe, DNA, Organic acid, Infection, MRI, Optical mapping, PET, In situ hybridization, Drug discovery, Company, Genetic disorder, Real-time polymerase chain reaction, Comparative genomic hybridization, Pharmaceutical industry, Medical imaging, Microscope

This report deals with cytogenetics in a broader sense rather than the classical use mainly to describe the chromosome structure and identify abnormalities related to disease.

Key Points: 
  • This report deals with cytogenetics in a broader sense rather than the classical use mainly to describe the chromosome structure and identify abnormalities related to disease.
  • The scope of cytogenetics includes several technologies besides fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), and multicolor FISH.
  • Molecular cytogenetics includes the applications of nanobiotechnology, microarrays, real-time polymerase chain reaction (PCR), in vivo imaging, and single molecule detection.
  • The report includes summary profiles of 70 companies relevant to cytogenetics along with their 80 collaborations.

Bionano Genomics' Saphyr System Shown to be Indispensable for the Analysis of Certain Genetic Disease Causing Variants

Retrieved on: 
Thursday, October 15, 2020
Branches of biology, Biology, Mutation, Molecular evolution, Chromosomes, Gene duplication, Structural variation, Optical mapping, Segmental duplication on the human Y chromosome

Only Bionanos optical mapping technology can image single molecules that are so long that they span the segmental duplications.

Key Points: 
  • Only Bionanos optical mapping technology can image single molecules that are so long that they span the segmental duplications.
  • These repetitive sequences can interact with each other when sperm or eggs are created and their rearrangement can cause severe genetic disease.
  • Several novel SVs were detected for each locus, and the exact disease causing rearrangement was determined with much higher accuracy than was formerly possible without Saphyr.
  • An increasing number of studies have relied on Bionanos Saphyr system to characterize disease-causing structural variants that could not be correctly analyzed with other molecular techniques.

Top Researchers to Present Discoveries Made Possible by Bionano’s Saphyr System for Genome Imaging Technology at the ASHG 2019 Annual Meeting

Retrieved on: 
Wednesday, October 16, 2019
Branches of biology, Biology, Life sciences, Molecular biology, Biotechnology, DNA, DNA sequencing, Genetic mapping, In science, Optical mapping, Genomics, Gene mapping

ASHG 2019 represents a milestone for Bionano, with a record number of presentations demonstrating novel discoveries through our genome mapping technology, said Erik Holmlin, Ph.D., CEO of Bionano.

Key Points: 
  • ASHG 2019 represents a milestone for Bionano, with a record number of presentations demonstrating novel discoveries through our genome mapping technology, said Erik Holmlin, Ph.D., CEO of Bionano.
  • Optical mapping through Saphyr enables the direct observation of large genomic variations through imaging of fluorescently labeled, megabase-size native DNA molecules.
  • Next-generation sequencing (NGS), in contrast, relies on short-reads that piece together sequence fragments in an attempt to rebuild the actual structure of the genome.
  • Genome mapping resolves these structural variations for more insight into the genetic variations that cause disease.