Occipital lobe

How much energy do we expend thinking and using our brain?

Retrieved on: 
Tuesday, April 25, 2023

But does our brain burn more energy when engaging in mental athletics than it does during other activities, such as watching TV?

Key Points: 
  • But does our brain burn more energy when engaging in mental athletics than it does during other activities, such as watching TV?
  • Tracing brain energy consumption can be done using both sugar and oxygen, but oxygen is the more accessible option.
  • Tracing oxygen consumption, the brain accounts for about 20% of the body’s energy consumption, despite only representing 2% of its weight.

How do we know?

    • We can’t measure brain energy consumption in humans in this way, but we can follow the oxygen, as increased brain activity requires more oxygen.
    • Research indeed shows increased mental load (such as performing mental arithmetic, reasoning, or multitasking) is linked to increased oxygen consumption (measured via CO₂ release).

Can we measure oxygen use just in the brain?

    • That extra supply of oxygen-rich blood is region specific and can be (literally) channelled with micrometre precision to active neurons.
    • Since blood and its oxygen are weakly attracted by magnetic fields, we can use MRI (magnetic resonance imaging), a radiation-free tool, to obtain an, albeit indirect, measure of brain activity.
    • But unfortunately, we can’t use MRI to tell us how much energy our brain uses for different mental activities.

So, how much does brain activity increase?

    • MRI studies have shown attentively monitoring moving objects compared to passively watching them increases brain activity in our visual cortex by around 1%.
    • But interestingly, processing visual information leads to a reduction of activity in auditory areas, meaning we spend less energy processing the sounds in our environment.
    • This works the other way around as well: when we attend to auditory information, we reduce our visual processing activity.

Then why do we feel exhausted after too much mental activity?

    • Complex mental tasks are typically also emotionally challenging and lead to increased activation of our sympathetic nervous system, ultimately leading to mental and physical fatigue.
    • The good news is we don’t have to worry that too much mental activity will drain our brain energy.

Cognito Therapeutics Announces Gamma-Frequency Sensory Stimulation Decreases Brain Atrophy in Patients with Alzheimer’s Disease at AD/PD 2023

Retrieved on: 
Thursday, March 30, 2023

The results were presented at the AD/PD™ 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, on March 28–April 1, 2023 in Gothenburg, Sweden.

Key Points: 
  • The results were presented at the AD/PD™ 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, on March 28–April 1, 2023 in Gothenburg, Sweden.
  • Neuroimaging data was prospectively collected in the OVERTURE clinical trial (NCT03556280) along with safety, tolerability, and efficacy of Cognito Therapeutics’ medical device in participants with Alzheimer’s disease.
  • "The results presented at AD/PD 2023 from our Phase 2 OVERTURE clinical trial show that daily at-home use of our medical device decreases brain atrophy in Alzheimer’s patients,” said Brent Vaughan, CEO, Cognito Therapeutics.
  • We remain committed to advancing our research and development efforts in bringing our innovative neurotechnology device to patients."

Treatment for blindness successful in largest ever study

Retrieved on: 
Wednesday, February 26, 2020

A new treatment has been found to be successful in improving the vision of partially blind patients.

Key Points: 
  • A new treatment has been found to be successful in improving the vision of partially blind patients.
  • Published in the scientific journal Cortex, the study involved almost 300 patients, the largest number of patients to participate in a study like this.
  • Professor Sahraie explains: Blindness after brain injury is common and its effect on patients daily life is sudden.
  • This is extremely encouraging and we hope will be of benefit to the tens of thousands of people who live with blindness after brain injury.