CoImmune Announces Positive Results from Phase 1/2 Clinical Trial of Allogeneic CAR-CIK Cells in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia
DURHAM, N.C., Dec. 15, 2021 (GLOBE NEWSWIRE) -- CoImmune, Inc., a clinical stage immuno-oncology company working to redefine cancer treatment using best-in-class cellular immunotherapies, today announced that results from a Phase 1/2 clinical trial evaluating CARCIK-CD19, an investigational treatment based on the company’s chimeric antigen receptor (CAR) modified cytokine induced killer (CIK) cell platform, demonstrated sustained responses in pediatric and adult patients with B-cell acute lymphoblastic leukemia (B-ALL) who had relapsed after allogeneic hematopoietic stem cell transplantation (HSCT). The results were presented during an oral session at the American Society of Hematology’s (ASH) 63rd Annual Meeting & Exposition held December 11-14th in Atlanta, GA.
- Of the 21 patients infused in the multi-center dose-escalation trial, CARCIK-CD19 cells were obtained by HLA-identical sibling (n=6, 29%), matched unrelated (n= 7, 33%), and haploidentical donors (n=8, 38%).
- Complete response was achieved by 13 out of 21 patients (61.9%, 95%CI=38-82%), including 11 out of 15 patients who were treated with the two highest doses (73.3%, 95%CI=45-92%).
- We are focused on moving ahead with clinical programs in ALL and AML based on these impressive preclinical results.
- CoImmune is a privately held, clinical stage immuno-oncology company that will redefine cancer treatment using best-in-class cellular immunotherapies.