Hydralazine,
Issue 1,
DHT,
Pigment,
UBA52,
Neuroregeneration,
Prevalence,
Apoptosis,
PNI,
Serum,
Homeostasis,
Patient,
Ferroptosis,
JPA,
Neuron,
HYD,
Metformin,
Type,
Nerve,
BPH,
Hypopigmentation,
EB,
Depigmentation,
Met,
Oxidative stress,
Iron,
Pharmaceutical industry XI'AN, China, March 29, 2024 /PRNewswire/ -- Understanding the underlying mechanisms of normal and pathological cellular processes is essential for developing new drugs. Fortunately, modern techniques and experimental methods have greatly accelerated progress. The latest issue of JPA features three articles in which candidate compounds for treating complex disorders were successfully identified, alongside their detailed mechanisms of action.
Key Points:
- The first study investigated the use of metformin (Met), a drug used to manage type II diabetes, for treating benign prostate hyperplasia (BPH).
- The article was published in Volume 14, Issue 1 of the journal in January 2024 .
- Using the Drug Signatures Database, they identified hydralazine (HYD), a potent arterial vasodilator, as a potential UBA52 disruptor.
- Further studies will hopefully clarify the intricate connections among cellular processes, diseases, and potential drugs, paving the way for precise and efficient therapies.
Retrieved on:
Tuesday, February 27, 2024
Nerve,
Central nervous system,
Metabolism,
PXR,
Alzheimer's disease,
Testosterone,
PCN,
Research,
MSI,
Diabetic cardiomyopathy,
Inflammation,
Pathology,
Deficit spending,
Pregnane X receptor,
MALDI,
Neurotoxicity,
Dysbiosis,
JPA,
Hippocampus,
CYP,
Heart failure,
DCM,
Domestic airport,
Phenytoin,
Mass spectrometry,
PHT,
Triglyceride,
TMAO,
Transplant,
Glucocorticoid,
Lipid metabolism,
Patient,
Journal,
Glucose,
Heart,
Mouse,
Glycated hemoglobin,
Brain XI'AN, China, Feb. 27, 2024 /PRNewswire/ -- DCM is the leading cause of heart failure in patients with chronic diabetes, with unclear mechanisms and limited treatments. Another mystery is the regulation of cytochrome P450 enzymes (CYPs) in the central nervous system. Moreover, the link between the gut microbiome, microbiota-derived metabolites, and the progression of AD remains unknown. In the December issue of Journal of Pharmaceutical Analysis (JPA), three articles explore the interconnected pathologies of DCM, hippocampal neurotoxicity, and AD, offering a comprehensive insight.
Key Points:
- Moreover, the link between the gut microbiome, microbiota-derived metabolites, and the progression of AD remains unknown.
- In the December issue of Journal of Pharmaceutical Analysis (JPA), three articles explore the interconnected pathologies of DCM, hippocampal neurotoxicity, and AD, offering a comprehensive insight.
- Their findings, available online on 17 August 2023, were published in Volume 13, Issue 12 of the journal in December 2023.
- Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease
DMY,
Microangiopathy,
Neoplasm,
VEGF,
NAFLD,
Radiation,
Fe,
ATGL,
Disease,
Lung cancer,
TCM,
DR,
Risk,
Quality of life,
Diabetic retinopathy,
Journal,
Nano,
Traditional Chinese medicine,
Liver,
Noetics,
Protein,
HSP90,
CDC37,
Non-alcoholic fatty liver disease,
Iron XI'AN, China, Jan. 26, 2024 /PRNewswire/ -- Despite demonstrating significant clinical efficacy against various diseases, the widespread use of Traditional Chinese Medicine (TCM) is still limited.
Key Points:
- XI'AN, China, Jan. 26, 2024 /PRNewswire/ -- Despite demonstrating significant clinical efficacy against various diseases, the widespread use of Traditional Chinese Medicine (TCM) is still limited.
- To address this gap, a new issue of the Journal of Pharmaceutical Analysis presents three independent studies which assessed the potency of TCM-based compounds for various human diseases, along with their molecular mechanisms of action.
- Oridonin (ORI), a TCM derived from the Chinese herb Rabdosia rubescens, exhibits anti-inflammatory effects.
- These studies provide a scientific basis for the development of TCM-based compounds into effective targeted therapies for various diseases.
Retrieved on:
Friday, December 15, 2023
Kidney,
OAT,
Chronic pain,
Live Phish Volume 13,
Hope,
Colorectal cancer,
Acute kidney injury,
Recycling,
CRC,
Cytoplasm,
Mouse,
Analgesic,
MRP4,
MOR,
Dicarboxylic acid,
Endocytosis,
Cancer,
Kynurenic acid,
Morphine,
Biomarker,
Rat,
CDK5,
JPA,
Histone deacetylase inhibitor,
Pharmaceutical industry XI'AN, China, Dec. 15, 2023 /PRNewswire/ -- Long-term use of analgesics such as morphine leads to "tolerance" that reduces drug efficacy. In such cases, dose escalation may be required to achieve the same analgesic effects. The key molecular mechanism of morphine tolerance is its inefficiency in inducing mu-opioid receptor (MOR) endocytosis. None of the currently available strategies to counter morphine tolerance address this underlying molecular mechanism. Moreover, understanding how drugs work is crucial to determine their efficacy. There is also an unmet need for new diagnostic biomarkers that can help identify diseases at an early stage. The October issue of JPA features three articles that address these issues and systematically lay a foundation for future studies and treatment strategies.
Key Points:
- XI'AN, China, Dec. 15, 2023 /PRNewswire/ -- Long-term use of analgesics such as morphine leads to "tolerance" that reduces drug efficacy.
- The October issue of JPA features three articles that address these issues and systematically lay a foundation for future studies and treatment strategies.
- In the second study , researchers dug deeper into the anticancer mechanisms of the drug 'pracinostat,' which is a histone deacetylase inhibitor (HDACi).
- Corresponding author Prof. Xinan Wu speculates by saying, "Our findings could aid in adjusting drug dosage or predicting renal injury via OAT channels."
Retrieved on:
Tuesday, November 28, 2023
Hepatitis,
MEFV,
Dave's Picks Volume 13,
Hope,
Pneumonia,
Liver,
HSP90,
Panax notoginseng,
Macrophage,
Mouse,
Journal,
Colitis,
Metabolism,
Ulcerative colitis,
Ethanol,
GI,
NLRP3,
SNZ,
ALD,
UC,
JPA,
Pharmaceutical industry XI'AN, China, Nov. 28, 2023 /PRNewswire/ -- Chronic gastrointestinal (GI) disorders are becoming increasingly common throughout the world, but many of them still lack effective treatment. Researchers have now turned to natural compounds, such as those present in traditional medicines, to search for potential drug candidates for difficult-to-treat diseases. The latest issue of the Journal of Pharmaceutical Analysis (JPA) features three articles that report promising findings and could pave the way to treatments for complex diseases affecting the liver and intestine.
Key Points:
- Researchers have now turned to natural compounds, such as those present in traditional medicines, to search for potential drug candidates for difficult-to-treat diseases.
- The latest issue of the Journal of Pharmaceutical Analysis (JPA) features three articles that report promising findings and could pave the way to treatments for complex diseases affecting the liver and intestine.
- The article was available online in July 2023 and published in Volume 13, Issue 9 of JPA in September 2023 .
- Moreover, Rk2 also restored intestinal barrier function by enhancing NLPR6 signaling in the intestine, demonstrating its multifaceted therapeutic potential.
Retrieved on:
Tuesday, October 17, 2023
Male,
ICH,
Myocardial infarction,
IGF1,
Stroke,
Brain,
Intracerebral hemorrhage,
UPK3B (gene),
JPA,
Reactive oxygen species,
Toxicity,
ECM,
Patient,
Spatial analysis,
PLX3397,
Journal,
Microglia,
Mouse,
Extracellular matrix,
Dick's Picks Volume 13,
Transcriptome,
Astrocyte,
Prognosis,
Inflammation,
Research,
Medical imaging,
Pharmaceutical industry,
C3 This comprehensive understanding paves the way for them to uncover some intricate and previously unknown disease mechanisms.
Key Points:
- This comprehensive understanding paves the way for them to uncover some intricate and previously unknown disease mechanisms.
- Three articles in the most recent special issue of the Journal of Pharmaceutical Analysis (JPA) discuss how single-cell and spatially resolved omics help unravel intercellular dynamics, aiding the development of novel therapeutic modalities.
- The article was available online in February 2023 and published in Volume 13, Issue 8 of JPA in August 2023 .
- Together, these articles enlighten us with a deeper understanding of cellular mechanisms at the single-cell and spatial levels, offering hope for improved treatment strategies in the future.
Retrieved on:
Tuesday, September 19, 2023
Communication,
Therapy,
Macrophage,
ATAC,
AEW,
JPA,
Ageing,
Cannabinoid,
Atopic dermatitis,
Medicine,
Research,
Gene expression,
RNA,
Immunology,
Immunotherapy,
Psoriasis,
B cell,
Incidence,
Neuroscience,
Patient,
Cancer,
Keratinocyte,
Immune system,
Biology,
Mouse,
Dick's Picks Volume 13,
Microglia,
CSF,
APP,
AD,
Tumor microenvironment,
Alzheimer's disease,
Cannabidiol,
Vaccine,
CBD The latest Special Issue of JPA features three articles showcasing tremendous advances and potential of these approaches for uncovering novel biological insights and informing the development of novel therapeutics.
Key Points:
- The latest Special Issue of JPA features three articles showcasing tremendous advances and potential of these approaches for uncovering novel biological insights and informing the development of novel therapeutics.
- The first study investigated the potential of cannabidiol (CBD), a compound found in the cannabis plant, for the treatment of colorectal tumors.
- The article was available online in April 2023 and published in Volume 13, Issue 7 of the journal in July 2023 .
- These studies offer hope that further research using single-cell and spatially resolved omics would ultimately lead to treatments for challenging diseases.
Retrieved on:
Wednesday, August 9, 2023
Neuron,
DNA,
Non-small-cell lung cancer,
Hearing loss,
JPA,
XPO1,
Cancer,
Quality of life,
Research,
NSCLC,
Cisplatin,
Liver,
DNA repair,
HIV disease progression rates,
Patient,
Apoptosis,
Cell cycle,
METTL3,
Dick's Picks Volume 13,
Ataxia–telangiectasia,
Leukemia,
Kinetics,
ATR,
PRMT5,
Pharmaceutical industry XI'AN, China, Aug. 9, 2023 /PRNewswire/ -- Although cancer treatment has advanced significantly over the last decade, some fairly common cancers remain extremely difficult to treat. Besides, some chemotherapeutics or anti-cancer drugs can have serious, irreversible side-effects. The latest issue of the JPA features three articles that highlight novel treatment strategies based on cutting-edge research on cancer and chemotherapeutic drug-induced adverse events.
Key Points:
- The latest issue of the JPA features three articles that highlight novel treatment strategies based on cutting-edge research on cancer and chemotherapeutic drug-induced adverse events.
- The first study reports a new approach to prevent hearing loss induced by the widely used chemotherapeutic drug "cisplatin".
- The article was available online in April 2023 and published in Volume 13, Issue 6 in June 2023 .
- A better understanding of the role of PRMT5 in hearing loss could help scientists develop effective hearing protection drugs and prevent this unwanted side-effect.
Hepatotoxicity,
Hepatocellular carcinoma,
Amiodarone,
JPA,
Nay,
Physiology,
Liver injury,
Dicarboxylic acid,
Hydroxylation,
Biomarker,
Proteomics,
Hepatocyte,
Arachidonic acid,
Plasma,
Protein,
Journal,
Metabolism,
Patient,
AKT,
MSI,
AMI,
Cancer,
Liver,
Growth,
Protein corona,
Environment,
HCC,
Medical imaging Drug-induced hepatotoxicity is routinely assessed during drug screening, which involves the use of two-dimensional (2D) monolayers of hepatocytes.
Key Points:
- Drug-induced hepatotoxicity is routinely assessed during drug screening, which involves the use of two-dimensional (2D) monolayers of hepatocytes.
- We coupled airflow-assisted desorption electrospray ionization-MSI with 3D HepG2 spheroids to assess the metabolism and hepatotoxicity of amiodarone (AMI)."
- Researchers show how NaY, a newly synthesized zeolite adsorbs and traps proteins from blood plasma, thus forming a protein corona or layer.
- The third study focuses on the potential treatment of hepatocellular carcinoma (HCC), the third leading cause of cancer-related deaths globally.
Elasticity,
CVD,
Saponin,
Panax notoginseng,
Workflow,
JPA,
Cancer,
Paclitaxel,
Research,
PG,
RNA,
PN,
Transcriptome,
Patient,
Doxorubicin,
Coagulation,
Immunohistochemistry,
Dave's Picks Volume 13,
Gene,
Breast cancer,
Medical imaging,
Vaccine XI'AN, China, June 22, 2023 /PRNewswire/ -- Cancer and cardiovascular diseases (CVDs) continue to be two of the biggest challenges facing modern medicine. Developing better diagnostic procedures, as well as drug screening and assessment techniques, are crucial steps in the path to more effective treatments. The latest issue of the JPA features three articles on cutting-edge research in these directions.
Key Points:
- Developing better diagnostic procedures, as well as drug screening and assessment techniques, are crucial steps in the path to more effective treatments.
- The latest issue of the JPA features three articles on cutting-edge research in these directions.
- Their findings indicated that saponins found in PG and PN may regulate genes involved in CVD and coagulation, respectively.
- In the third study , researchers show how the mechanical and physiological properties of a cell can be useful for evaluating drug efficacy.
