Traffic barrier

• Golidocitinib is the first and only Janus kinase 1 (JAK1) selective inhibitor in the NDA stage for the treatment of r/r PTCL.
• Golidocitinib monotherapy demonstrated superior efficacy and safety profile in the full analysis of the JACKPOT8 PARTB study, which was consistent with the preliminary findings presented at 2023 ASCO.
• The pooled analysis results from these two studies will be presented for the first time at 2023 ASH.
• Golidocitinib in Treating Refractory or Relapsed Peripheral T- Cell Lymphoma: Full Analysis of the Multinational Pivotal Study Results (JACKPOT8)

• Envelta utilizes a novel and patented intranasal drug delivery system, Molecular Envelope Technology (MET) to bypass the blood-brain barrier.
• The MET was developed by Nanomerics, Ltd. , a UK-based nanotechnology research and development company that has licensed its MET-LENK to Virpax.
• The nose-to-brain MET platform protects molecules from biodegrading and enhances the bioavailability of product candidates on its transport to the brain.
• “We are grateful to the FDA for the thorough and clear direction that was provided to us in our pre-IND meeting.

Perhaps the word “polyphenol” means little to you, but they certainly mean a lot to your health. Polyphenols are a family of chemical compounds present in foods of vegetable origin and seaweed that have been studied over the last century for their health effects.

The beginning: taste and technology

• Uses date back to Ancient Egypt, when chemicals in the bark of certain trees were found to bind with the collagen in animal skin, making leather.
• This sensation, known as astringency, comes from the interaction between tannins and salivary proteins in your mouth.

Natural antioxidants

• Polyphenols are natural antioxidants, which means they can counteract harmful free radicals in the body.
• When animals eat a plant, the polyphenols’ antioxidant properties then in turn counteract free radicals in the animal’s body.
• This antioxidant effect from foods is important for human health, since many diseases (cardiovascular diseases, cancer, type 2 diabetes, etc.)

Much more than antioxidants

• This happened when several studies found that, once consumed, polyphenols are transformed by our bodies, mostly by our gut microbiota.
• But the good news was that, besides their antioxidant activity, polyphenols were also discovered to have many more properties.
• This has not only been observed in test tubes, but also in multiple clinical trials in different populations.

The gut-brain axis

• Although much more research is still needed, some promising evidence shows that polyphenols may also help our cognitive function and improve our sleep.
• There is, however, something known as the gut-brain axis.
• This new field of research is very much in its infancy, with much left to be explored.

The future for polyphenol research

• We have come a long way in our knowledge of dietary polyphenols over the last century.
• Hopefully, we will have answers to some of these questions in years to come.

• Jara Pérez Jiménez ha recibido, como investigadora principal, fondos en los últimos cinco años del Ministerio de Ciencia e Innovación (España) y la Comisión para la Uva de la Mesa de California.
• Margaret Slavin has received, as principal investigator, funding over the past five years from the United States Department of Agriculture, George Mason University, and the American Egg Board/Egg Nutrition Center.

• ALX-001 continues to demonstrate promise in ongoing studies that build on twelve years of research.
• The data will be presented by principal investigator Adam Mecca, M.D., Ph.D.
• This study evaluated the safety, tolerability, pharmacokinetics, and brain receptor occupancy of increasing doses of orally-administered ALX-001.
• “The potential for ALX-001 as a first-in-class oral therapy for neurodegenerative disease continues to be reinforced by a growing body of clinical evidence.”