Ptosis

Benitec Biopharma Reports Positive Interim Clinical Trial Data for First OPMD Subject Treated with BB-301 in Phase 1b/2a Study

Retrieved on: 
Thursday, April 18, 2024
FDA, Dysphagia, Mutation, EDT, Nature, COMP, Oculopharyngeal muscular dystrophy, Hope, Food, News, Death, Yogurt, Pharmacotherapy, Observation, PABPN1, Disease, OPMD, Subject, Ptosis, Patient, EMA, Caregiver, Committee, Clinical trial, Trial of the century, Orphan drug, European Medicines Agency, Pharmaceutical industry

HAYWARD, Calif., April 18, 2024 (GLOBE NEWSWIRE) -- Benitec Biopharma Inc. (NASDAQ: BNTC) (“Benitec” or “Company”), a clinical-stage, gene therapy-focused, biotechnology company developing novel genetic medicines based on its proprietary “Silence and Replace” DNA-directed RNA interference (“ddRNAi”) platform, today announces positive interim clinical data from the 90-day timepoint following the administration of BB-301 to the study’s first subject (Subject 1) treated in the BB-301 Phase 1b/2a single-arm, open-label, sequential, dose-escalation cohort study (NCT06185673) in Oculopharyngeal Muscular Dystrophy (OPMD). BB-301 has been granted Orphan Drug designation by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP).

Key Points: 
  • “To date, no clinical studies have systematically demonstrated a clinical improvement in OPMD patients across both objective and subjective measures of swallowing.
  • We are, therefore, pleased to report positive interim clinical data from multiple radiographic measures as well as subject-reported outcome measures from the first subject treated with BB-301,” said Jerel A.
  • Videofluoroscopic swallowing studies represent the gold standard analytical method for the quantitative assessment of dysphagia (swallowing difficulty) in the clinical setting.
  • The event replay will be placed on the News & Events tab on the Investor page of the Benitec website.

AEON Biopharma Presents Positive Clinical and Pre-clinical Data for ABP-450 (prabotulinumtoxinA) in Treating Cervical Dystonia and PTSD, Respectively, at a Leading Neurotoxin Conference

Retrieved on: 
Thursday, January 18, 2024
AEON, Clavicle, Patient, Heart rate, Research, PTSD, Post-traumatic stress disorder, AB toxin, Stellate ganglion, OLE, Neck, DSM-IV codes, Torticollis, Safety, INA, DBP, Head, Botulinum toxin, Lidocaine, IND, Ptosis, FDA, Toxicity, Rat, SGB, Acute stress disorder, Data, Week, Anatomy, Pharmaceutical industry

IRVINE, Calif., Jan. 18, 2024 (GLOBE NEWSWIRE) -- AEON Biopharma, Inc. (“AEON” or the “Company”) (NYSE: AEON, AEON WS), a clinical-stage biopharmaceutical company focused on developing a proprietary botulinum toxin complex for the treatment of multiple debilitating medical conditions, today presented new clinical and pre-clinical data for ABP-450 in treating cervical dystonia (CD) and posttraumatic stress disorder (PTSD) at TOXINS 2024, a leading conference held by the International Neurotoxin Association (INA) from January 17th - 20th at the Estrel Berlin in Berlin, Germany.

Key Points: 
  • ABP-450 did not appear to increase treatment-related TEAEs at any dose in the study.
  • These results support further investigation of ABP-450 as a treatment option for patients with CD and other movement disorders.
  • “We are excited to announce positive data from the 52-week OLE portion of the Phase 2 study of ABP-450 for CD.
  • The posters presented by AEON at the TOXINS 2024 conference can be accessed on the Events and Presentations page of the Company’s corporate website.

Clear vision for the future: Canadian Ophthalmological Society celebrates Indigenous Children Eye Examination Project, impacting 6,000 lives to date

Retrieved on: 
Tuesday, August 8, 2023
Retina, Vision disorder, Fort Albany, Eye Health UK, Travel, Strabismus, ICEE, DSM-IV codes, Kashechewan First Nation, Weenusk First Nation, Eye, Ptosis, Light, Cataract, Refractive error, Attawapiskat First Nation, System, Fort Albany First Nation, Approximation error, Radar, COS, Growth, Moose Cree First Nation, Ageing, Amblyopia, American Ophthalmological Society, Toy, Telescopic sight, Indigenous

This model is designed to benefit Indigenous children in underserved areas of Canada and involves training local youth to assess children for eye problems.

Key Points: 
  • This model is designed to benefit Indigenous children in underserved areas of Canada and involves training local youth to assess children for eye problems.
  • "Many children in these Indigenous communities have to travel over one hour by plane to see an eye care professional.
  • It is critical to develop a national vision screening strategy to prevent long-lasting vision loss, especially in children.
  • ICEE aims to become the national outreach program for delivering eye care to Indigenous children living in the remote and under-served parts of Canada."

RVL Pharmaceuticals plc to Discuss Second Quarter 2023 Financial Results and Provide Commercial Update

Retrieved on: 
Wednesday, August 2, 2023
Blood pressure, Glaucoma, Blepharoplasty, Ptosis, Orthostatic hypotension, Hypotension, Conference call, Focal neurologic signs, Stroke, Cardiovascular disease, Eye, Orbit, Myasthenia gravis, Beta blocker, Hypertension, Telecanthus, Ophthalmoparesis, Metabolism, Patient, Xanthine oxidase inhibitor, Risk, Eye injury, Glycosidic bond, System, Aneurysm, Headache, Conference, Horner's syndrome, Phosphorus, Pharmaceutical industry

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is indicated for the treatment of acquired blepharoptosis in adults.

Key Points: 
  • UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is indicated for the treatment of acquired blepharoptosis in adults.
  • Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses.
  • Consideration should be given to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.
  • Caution is advised in patients taking monoamine oxidase inhibitors which can affect the metabolism and uptake of circulating amines.

RVL Pharmaceuticals plc to Discuss First Quarter 2023 Financial Results and Provide Commercial Update

Retrieved on: 
Thursday, May 4, 2023
Blood pressure, Glaucoma, Blepharoplasty, Ptosis, Orthostatic hypotension, Hypotension, Focal neurologic signs, Stroke, Cardiovascular disease, Eye, Orbit, Myasthenia gravis, Beta blocker, Hypertension, Telecanthus, Ophthalmoparesis, Metabolism, Patient, Xanthine oxidase inhibitor, Risk, Eye injury, Glycosidic bond, System, Aneurysm, Headache, Horner's syndrome, Phosphorus, Pharmaceutical industry

Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses.

Key Points: 
  • Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses.
  • Consideration should be given to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.
  • Advise UPNEEQ patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens.
  • Caution is advised in patients taking monoamine oxidase inhibitors which can affect the metabolism and uptake of circulating amines.

RVL Pharmaceuticals Announces that Upneeq® Wins “Best Eye Drop for Drooping Lids” NewBeauty in 13th Annual Beauty Awards

Retrieved on: 
Monday, April 3, 2023
Blood pressure, Heart, Pressure, Blepharoplasty, Bureau of Oceans and International Environmental and Scientific Affairs, Marketing, Stroke, Ptosis, Eye, GameChanger, Myasthenia gravis, Brain, Prostate, Aneurysm, Doctor of Philosophy, Hypertension, Telecanthus, Beauty, Eyelid, Patient, Xanthine oxidase inhibitor, Risk, Nature, Annual report, Eye injury, Security (finance), Cover My Eyes (Pain and Heaven), Dry, FDA, Headache, Glaucoma, Safety, Mouth, Horner's syndrome, Pharmaceutical industry, Telescopic sight, Medical device, Veterinary medicine, Nursing, Oxymetazoline

BRIDGEWATER, N.J., April 03, 2023 (GLOBE NEWSWIRE) --  RVL Pharmaceuticals plc (Nasdaq: RVLP) (“RVL” or the “Company”) announced today that its prescription eye drop Upneeq® (oxymetazoline hydrochloride ophthalmic solution), 0.1% has been selected the winner in the professional treatment category as “Best Eye Drop for Drooping Lids” in the NewBeauty 13th Annual Beauty Awards.

Key Points: 
  • BRIDGEWATER, N.J., April 03, 2023 (GLOBE NEWSWIRE) --  RVL Pharmaceuticals plc (Nasdaq: RVLP) (“RVL” or the “Company”) announced today that its prescription eye drop Upneeq® (oxymetazoline hydrochloride ophthalmic solution), 0.1% has been selected the winner in the professional treatment category as “Best Eye Drop for Drooping Lids” in the NewBeauty 13th Annual Beauty Awards.
  • The 13th Annual NewBeauty Awards issue hits newsstands on April 4, 2023.
  • First-in-class, Upneeq® is a safe and effective, fast acting, daily treatment for patients at eye care and medical aesthetic practices nationally.
  • The most common adverse reactions with Upneeq (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

Upneeq® Wins "Best Eye Drop for Drooping Lids" New Beauty In 13th Annual Beauty Awards

Retrieved on: 
Friday, March 31, 2023
Blood pressure, Heart, Pressure, Blepharoplasty, Bureau of Oceans and International Environmental and Scientific Affairs, Stroke, Ptosis, Eye, Myasthenia gravis, Brain, Prostate, Aneurysm, Doctor of Philosophy, Hypertension, Telecanthus, Beauty, Eyelid, Patient, Xanthine oxidase inhibitor, Risk, Eye injury, Cover My Eyes (Pain and Heaven), Dry, FDA, Headache, Glaucoma, Safety, Mouth, Horner's syndrome, GameChanger, Pharmaceutical industry, Telescopic sight, Medical device, Veterinary medicine, Nursing, Oxymetazoline

BRIDGEWATER, N.J., March 31, 2023 /PRNewswire-PRWeb/ -- RVL Pharmaceuticals announced today that its prescription eye drop Upneeq® (oxymetazoline hydrochloride ophthalmic solution), 0.1% has been selected the winner in the professional treatment category as "Best Eye Drop for Drooping Lids" in the NewBeauty 13th Annual Beauty Awards. Upneeq is FDA approved for the treatment of acquired blepharoptosis (droopy eyelids) in adults. It is the second consecutive win for the brand. Upneeq® was awarded the "Best Innovation" in 2022 by this definitive authority in beauty. The 13th Annual NewBeauty Awards issue hits newsstands on April 4, 2023.

Key Points: 
  • BRIDGEWATER, N.J., March 31, 2023 /PRNewswire-PRWeb/ -- RVL Pharmaceuticals announced today that its prescription eye drop Upneeq® (oxymetazoline hydrochloride ophthalmic solution), 0.1% has been selected the winner in the professional treatment category as "Best Eye Drop for Drooping Lids" in the NewBeauty 13th Annual Beauty Awards.
  • The 13th Annual NewBeauty Awards issue hits newsstands on April 4, 2023.
  • The most common adverse reactions with Upneeq (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.
  • The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

RVL Pharmaceuticals plc to Discuss Fourth Quarter and Full Year 2022 Financial Results and Provide Commercial Update

Retrieved on: 
Wednesday, March 15, 2023
Ophthalmoparesis, Conference, Myasthenia gravis, Hypotension, Glaucoma, Eye, International, Patient, Blood pressure, Horner's syndrome, Risk, URL, Telecanthus, Focal neurologic signs, Aneurysm, Hypertension, Metabolism, Beta blocker, Orthostatic hypotension, Ptosis, Eye injury, Glycosidic bond, Blepharoplasty, Cardiovascular disease, ID, Conference call, Headache, System, Orbit, Stroke, Xanthine oxidase inhibitor, Phosphorus, Pharmaceutical industry

UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is indicated for the treatment of acquired blepharoptosis in adults.

Key Points: 
  • UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is indicated for the treatment of acquired blepharoptosis in adults.
  • Consideration should be given to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.
  • Advise UPNEEQ patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens.
  • Caution is advised in patients taking monoamine oxidase inhibitors which can affect the metabolism and uptake of circulating amines.

RVL Pharmaceuticals plc Announces Preliminary Fourth Quarter Sequential Growth of 21% and Full Year 2022 UPNEEQ® Net Product Sales

Retrieved on: 
Monday, January 9, 2023
Cardiovascular disease, Security (finance), Xanthine oxidase inhibitor, Hypertension, Orthostatic hypotension, Aneurysm, Eye injury, Glycosidic bond, Focal neurologic signs, Headache, Blood pressure, FDA, Risk, Food and Drug Administration, Ptosis, Hypotension, Glaucoma, Telehealth, Orbit, Blepharoplasty, Marketing, Patient, Food, Growth, Annual report, Metabolism, Horner's syndrome, Duane syndrome, Ophthalmoparesis, Stroke, RVL, Beta blocker, Nature, Eye, Myasthenia gravis, Pharmaceutical industry, Phosphorus

BRIDGEWATER, N.J., Jan. 09, 2023 (GLOBE NEWSWIRE) -- RVL Pharmaceuticals plc (Nasdaq: RVLP) (“RVL” or the “Company”), a specialty pharmaceutical company, today announced preliminary fourth quarter and full year 2022 net product sales of UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1%, the first and only U.S. Food and Drug Administration (“FDA”)-approved ophthalmic solution for blepharoptosis, or droopy eyelids, of approximately $12.1 million and $36.5 million, respectively. The preliminary fourth quarter 2022 net product sales of UPNEEQ represent a sequential increase of 21% from the third quarter 2022. The Company also announced that from February through year-end 2022 it had received orders from approximately 4,300 cumulative unique medical aesthetics practices.

Key Points: 
  • The preliminary fourth quarter 2022 net product sales of UPNEEQ represent a sequential increase of 21% from the third quarter 2022.
  • “We are proud of our progress in the fourth quarter, notably the continued upward trajectory of net product sales for UPNEEQ.
  • On a full-year basis, we expect our UPNEEQ revenues to exceed $36 million, representing nearly 400% growth over 2021.
  • The financial and operating data for the fourth quarter of 2022 and for the full year 2022 is preliminary and may change.

RVL Pharmaceuticals plc to Present at the Cantor Medical & Aesthetic Dermatology, Ophthalmology & MedTech/Diagnostic Conference

Retrieved on: 
Thursday, December 1, 2022
Hypertension, Patient, Stroke, Orbit, Duane syndrome, Headache, Glycosidic bond, Glaucoma, Orthostatic hypotension, Risk, Cardiovascular disease, Myasthenia gravis, Horner's syndrome, Aneurysm, Beta blocker, Blood pressure, Hypotension, Focal neurologic signs, Ptosis, Eye injury, Xanthine oxidase inhibitor, Ophthalmoparesis, Eye, Metabolism, Blepharoplasty, Phosphorus, Pharmaceutical industry

Consideration should be given to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.

Key Points: 
  • Consideration should be given to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.
  • Advise UPNEEQ patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens.
  • Advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop.
  • Caution is advised in patients taking monoamine oxidase inhibitors which can affect the metabolism and uptake of circulating amines.