Children’s Hospital Los Angeles Researchers Develop Clinical Tool to Predict if a Child in Acute Liver Failure Will Need a Transplant
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Monday, October 23, 2023
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Unlike children with chronic liver disease, previously healthy children who develop acute liver failure can suddenly deteriorate.
Key Points:
- Unlike children with chronic liver disease, previously healthy children who develop acute liver failure can suddenly deteriorate.
- While pediatric acute liver failure has been linked to both viral hepatitis and drug-induced liver injury, at least half of cases have no apparent trigger.
- The CHALF Score predicts if a child experiencing acute liver failure will recover or should be referred to a transplant center.
- Doctors do not want to refer a child for liver transplant who could otherwise recover with medical treatment—about 70% of children with acute liver failure recover while keeping their original liver.