Duke School

Wistar Scientists Discover New Immunosuppressive Mechanism in Brain Cancer

Retrieved on: 
Friday, May 3, 2024
Cell, National Cancer Institute, Macrophage, Sapienza University of Rome, Genome, Glucose, Wistar Institute, Gene, Brain, Tumor microenvironment, Wistar, Metabolomics, Neuroscience, Immunity, Ben, Medical research, Microglia, Research, Proteomics, Immunology, Histone, Malignancy, Gene expression, Neoplasm, Aurelia, Cancer, Collaborative writing, DSM-IV codes, Prognosis, Immunosuppression, Immunotherapy, Duke School, Disease, GLUT1, Patient, Metabolism, Immune system, Angelica, Vaccine

The lab’s discovery was published in the paper, “ Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma ,” in the journal Immunity.

Key Points: 
  • The lab’s discovery was published in the paper, “ Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma ,” in the journal Immunity.
  • Indeed, monocyte-derived macrophages, but not microglia, blocked the activity of T cells (immune cells that destroy tumor cells), in preclinical models and patients.
  • Glioblastoma is inherently dangerous due to its location in the brain and its immunosuppressive tumor microenvironment, which renders glioblastoma resistant to promising immunotherapies.
  • Note: The work detailed in this publication was initiated at The H. Lee Moffitt Cancer Center during Dr. Veglia’s time there and continued at Wistar.

Matt Spielman’s “INFLECTION POINTS” Delivers a Game Plan for Identifying and Accomplishing Career, Life Goals

Retrieved on: 
Tuesday, May 24, 2022
Retail, Blogging, Other Communications, Publishing, Books, Communications, Other Consumer, Other Entertainment, Women, Online Retail, Other Retail, Men, Specialty, Entertainment, Consumer, National Board for Certified Counselors, Inflection point, MBA, Alternative medicine, Spielmann, Take-Two Interactive, Harvard University, The Lego Movie, CBS, Wellness, Multimedia, Publishing, CBS Radio, CBS News, ICF, Executive, Radio, Interview, ZMC, Life, Organization, Wiley, Institutional Investor, Duke School, GPS, LinkedIn, Harvard Business School, News, Columbia University, MVP, CEO, Management, Book

Spielman, a Columbia and Harvard trained performance coach, uses his trademarked Game Plan System (GPS for short) that provides a roadmap for choosing objectives and developing easy-to-use strategies for accomplishing them.

Key Points: 
  • Spielman, a Columbia and Harvard trained performance coach, uses his trademarked Game Plan System (GPS for short) that provides a roadmap for choosing objectives and developing easy-to-use strategies for accomplishing them.
  • INFLECTION POINTS teaches how to celebrate wins, handle setbacks, achieve consequential goals and create new ones.
  • Kirsten Fitzpatrick, Managing Director, MBA Career and Professional Development, Harvard Business School
    Reading Inflection Points is like taking a long walk with the very wise Matt Spielman.
  • Matt Spielmans new book, Inflection Points: How to Work and Live with Purpose, is now available wherever books and e-books are sold.