Making Long-Term Memories Requires Nerve-Cell Damage
Retrieved on:
Wednesday, March 27, 2024
Inflammation, Radulović, Psychiatry, Brain, TLR9, COVID, Gene, DNA repair, DSM-IV codes, Cell division, Genome instability, University Medical Center, Infection, Memory, Organelle, Hippocampus, Mouse, DNA, Albert Einstein, Nature, Cancer, Toll-like receptor 9, Neuron, Northwestern University, Doctor of Philosophy, Alzheimer's disease, Genome, Aarhus University, Cytoplasm, Cell, Dominic, B.A, Encephalitis, Ageing, Vaccine
"But our findings suggest that inflammation in certain neurons in the brain's hippocampal region is essential for making long-lasting memories."
Key Points:
- "But our findings suggest that inflammation in certain neurons in the brain's hippocampal region is essential for making long-lasting memories."
- But looking more closely, we found, to our surprise, that TLR9 was activated only in clusters of hippocampal cells that showed DNA damage."
- But in this population of hippocampal neurons, the DNA damage appeared to be more substantial and sustained.
- Importantly, the researchers found that blocking the TLR9 inflammatory pathway in hippocampal neurons not only prevented mice from forming long-term memories but also caused profound genomic instability, i.e, a high frequency of DNA damage in these neurons.