Genome instability

Making Long-Term Memories Requires Nerve-Cell Damage

Retrieved on: 
Wednesday, March 27, 2024
Inflammation, Radulović, Psychiatry, Brain, TLR9, COVID, Gene, DNA repair, DSM-IV codes, Cell division, Genome instability, University Medical Center, Infection, Memory, Organelle, Hippocampus, Mouse, DNA, Albert Einstein, Nature, Cancer, Toll-like receptor 9, Neuron, Northwestern University, Doctor of Philosophy, Alzheimer's disease, Genome, Aarhus University, Cytoplasm, Cell, Dominic, B.A, Encephalitis, Ageing, Vaccine

"But our findings suggest that inflammation in certain neurons in the brain's hippocampal region is essential for making long-lasting memories."

Key Points: 
  • "But our findings suggest that inflammation in certain neurons in the brain's hippocampal region is essential for making long-lasting memories."
  • But looking more closely, we found, to our surprise, that TLR9 was activated only in clusters of hippocampal cells that showed DNA damage."
  • But in this population of hippocampal neurons, the DNA damage appeared to be more substantial and sustained.
  • Importantly, the researchers found that blocking the TLR9 inflammatory pathway in hippocampal neurons not only prevented mice from forming long-term memories but also caused profound genomic instability, i.e, a high frequency of DNA damage in these neurons.

GC Genome Announces Publication Demonstrating Feasibility of Liquid Biopsy Technology to Predict Radiation Therapy Response in Solid Tumors

Retrieved on: 
Monday, April 10, 2023
Pancreatic cancer, CIN, BMC, Oncology, DNA, VEGFA, Samsung Medical Center, Genome instability, Nucleic acid thermodynamics, Hepatocellular carcinoma, Sorafenib, CAP, Neoplasm, Survival, University, Cancer, Head, Research, Attention, Genome, Biomarker, Lung, Infant, Plasma, Rare, SM, Patient, Basel, Esophageal cancer, SY, Sungkyunkwan University, Chemoradiotherapy, RT, GC, Disease, Medical imaging, Vaccine, MD

This study adds to the previous studies of prognostic effects of the I-score in various solid tumors, including hepatocellular carcinoma, esophageal cancer, and pancreatic adenocarcinoma1.2.3.

Key Points: 
  • This study adds to the previous studies of prognostic effects of the I-score in various solid tumors, including hepatocellular carcinoma, esophageal cancer, and pancreatic adenocarcinoma1.2.3.
  • Another interesting finding is that minimal residual disease following RT was detected earlier by cfDNA than by imaging studies.
  • "Further additional studies are ongoing to optimize the measurement and analysis of I-scores to predict radiation response accurately.
  • Such statements do not represent any guarantee by GC Genome or its management of future performance and involve known and unknown risks, uncertainties and other factors.

Global Genome Engineering Market to Surpass US$ 15,195.74 Million by 2030 - Coherent Market Insights

Retrieved on: 
Friday, July 15, 2022
Research, Thermo Fisher Scientific, RNA, Mindful Scientific Inc., Cancer, Streptomyces, ALS, Genome, CRISPR, Gene editing, CAGR, DSB, Technology, National academy, DNA, Genome instability, Pfizer, National Center for Biotechnology Information, National, US, Sangamo Therapeutics, Intellia Therapeutics, Merck Group, Gilead Sciences, PNAS, Growth, Analysis, ZFN, Amyotrophic lateral sclerosis, Pharmaceutical industry, Antibiotics

SEATTLE, July 15, 2022 /PRNewswire/ --According to Coherent Market Insights, the global genome engineering market is estimated to be valued at US$ 5,205.60 million in 2022 and is expected to exhibit a CAGR of 14.3% during the forecast period (2022-2030).

Key Points: 
  • SEATTLE, July 15, 2022 /PRNewswire/ --According to Coherent Market Insights, the global genome engineering market is estimated to be valued at US$ 5,205.60 million in 2022 and is expected to exhibit a CAGR of 14.3% during the forecast period (2022-2030).
  • Key Trends and Analysis of the Global Genome Engineering Market:
    Strategic collaboration of key players in market for genome engineering technologies is also expected to positively affect market growth.
  • Increasing strategic collaboration for genome engineering technologies by key players is expected to drive market growth over the forecast period.
  • Global genome engineering market is expected to exhibit a CAGR of 14.3% during the forecast period due to increasing research and development genome engineering technology.

Global Genome Engineering Market to Surpass US$ 15,195.74 Million by 2030 - Coherent Market Insights

Retrieved on: 
Friday, July 15, 2022
Research, Thermo Fisher Scientific, RNA, Mindful Scientific Inc., Cancer, Streptomyces, ALS, Genome, CRISPR, Gene editing, CAGR, DSB, Technology, National academy, DNA, Genome instability, Pfizer, National Center for Biotechnology Information, National, US, Sangamo Therapeutics, Intellia Therapeutics, Merck Group, Gilead Sciences, PNAS, Growth, Analysis, ZFN, Amyotrophic lateral sclerosis, Pharmaceutical industry, Antibiotics

SEATTLE, July 15, 2022 /PRNewswire/ --According to Coherent Market Insights, the global genome engineering market is estimated to be valued at US$ 5,205.60 million in 2022 and is expected to exhibit a CAGR of 14.3% during the forecast period (2022-2030).

Key Points: 
  • SEATTLE, July 15, 2022 /PRNewswire/ --According to Coherent Market Insights, the global genome engineering market is estimated to be valued at US$ 5,205.60 million in 2022 and is expected to exhibit a CAGR of 14.3% during the forecast period (2022-2030).
  • Key Trends and Analysis of the Global Genome Engineering Market:
    Strategic collaboration of key players in market for genome engineering technologies is also expected to positively affect market growth.
  • Increasing strategic collaboration for genome engineering technologies by key players is expected to drive market growth over the forecast period.
  • Global genome engineering market is expected to exhibit a CAGR of 14.3% during the forecast period due to increasing research and development genome engineering technology.

3D Genetic Structure in Blood Cancer Important Beyond DNA Code Changes

Retrieved on: 
Monday, March 23, 2020
Branches of biology, Biology, Gene expression, Myc, DNA, Epigenetics, Enhancer, Mutation, Regulation of gene expression, Gene, Origin of replication, Genome instability

Upon receiving the right signal, this arrangement changes to expose the gene-reading machinery to only those bits of DNA code needed for the job at hand in each cell.

Key Points: 
  • Upon receiving the right signal, this arrangement changes to expose the gene-reading machinery to only those bits of DNA code needed for the job at hand in each cell.
  • Within TAD boundaries, DNA is free to fold back on itself in 3D loops, bringing together enhancers and other elements (e.g., promoter DNA) that must interact for a given stretch of code to be read.
  • Researchers say their findings suggest that these 3D changes in chromosome structure are as important as changes in the order of molecular letters making up the DNA code itself (mutations), with both mechanisms encouraging cancer onset and progress.
  • However, a second experimental drug (targeting molecular, or epigenetic, changes in these DNA neighborhoods) effectively corrected DNA looping in the MYC neighborhood, restoring normal chromosomal structure and gene regulation, and dramatically decreasing MYC action and cancer spread.