Waist

• Hair Growth and Metabolism Booster supplements provide new ways for women to support their hair growth and weight goals through clinically shown ingredients that are drug-free.
• "We spent time listening to women share their struggles with hair growth and weight management, and their desire for products that are cost-effective and backed by nutrition research.
• "Our Hair Growth formula makes it easy for women to get nutrients clinically shown for the growth of thicker hair delivered in only one capsule per day and at an affordable price.
• Nature's Bounty® Optimal Solutions® Hair Growth features an Advanced Hair Complex, which is clinically shown to help grow thicker, fuller hair in three months.

• A 2020 report found that 14.7 million children and adolescents in the U.S. live with obesity.
• Because obesity is a known risk factor for serious health problems, its rapid increase during the COVID-19 pandemic raised alarms.
• Even before adulthood, some children will have serious health problems beginning in their preteen years.
• Some of these children have severe obesity and several health complications that require multiple specialists.

How obesity is measured

• Therefore most clinicians use body measurements to screen for obesity.
• Severe obesity occurs when a child reaches the 120th percentile or has a BMI over 35.
• Severe obesity carries a heightened risk of liver disease, cardiovascular disease and metabolic problems such as diabetes.
• As of 2016, almost 8% of children ages 2 to 19 had severe obesity.

How obesity affects the liver

• The liver disease associated with obesity is called nonalcoholic fatty liver disease.
• Under the microscope, a pediatric fatty liver looks similar to a liver with alcohol damage.
• Occasionally children with fatty liver are not obese; however, the greatest risk factor for fatty liver is obesity.
• Fatty liver is the second-most common reason for liver transplantation in the U.S., and it will be the leading cause in the future.

Links between obesity and diabetes

• In a telephone interview, Dr. Barry Reiner, a pediatric endocrinologist, voiced his concerns to me about obesity and diabetes.
• “When I started my practice, I had never heard of type 2 diabetes in children,” says Reiner.
• “Now, depending on which part of the U.S., between a quarter and a third of new cases of diabetes are type 2.” Type 1 diabetes is an autoimmune disease previously called juvenile-onset diabetes.
• However, type 2 diabetes is increasing in children, and obesity is the major risk factor.

Heart health

• Cardiovascular changes associated with obesity and severe obesity can also increase a child’s lifetime chance of heart attacks and strokes.
• Although still uncommon, more people in their 20s, 30s and 40s are having strokes and heart attacks than a few decades ago.

Talk about being healthy, not focusing on weight

• “Food, diet, lifestyle and weight are often a proxy for something greater going on in someone’s life,” says Kalami.
• Factors beyond a child’s control, including depression, access to healthy food and walkable neighborhoods, contribute to obesity.
• She adds that even preteens and teenagers should not be focusing on their weight, though they likely already are.
• “Help them pick what’s available and make the best choice, which may not be the perfect choice.” Any weight talk, either criticism or compliments for weight loss, may backfire, she adds.

• The trial was designed to enroll approximately 320 subjects with obesity or overweight with at least one co-morbidity and without diabetes.
• Subjects were randomized 1:1:1:1 to 1.2 mg, 1.8 mg, 2.4 mg pemvidutide or placebo administered weekly for 48 weeks in conjunction with diet and exercise.
• A pre-specified interim analysis was conducted after 160 subjects completed 24 weeks of treatment.
• We look forward to completing our 48-week MOMENTUM obesity trial in the fourth quarter of 2023 and initiating a Phase 2 biopsy NASH trial in mid-2023.”

• Metabolic syndrome is a condition characterized by central adiposity, high levels of fasting blood glucose, high blood levels of triglycerides, low blood levels of high-density lipoprotein (HDL) cholesterol, and hypertension (high blood pressure).
• Metabolic syndrome is associated with increased risk of cardiovascular disease, stroke, and type 2 diabetes.
• “Given the relationship between EVAF and metabolic syndrome, these data appear to suggest that tesamorelin could improve metabolic profiles in individuals with HIV who have central adiposity.”
  Researchers conducted a post-hoc analysis of data from two Phase III trials of tesamorelin in PWHIV with EVAF.
• However, following 26 weeks of tesamorelin treatment, the prevalence of metabolic syndrome decreased in responders, resulting in a significantly lower prevalence compared to non-responders (30.8% vs. 48.5%; p