International Conference on Population and Development

Aptose Presents Highlights from Clinical Update Webcast Featuring Latest Available Data on AML Drug Tuspetinib

Retrieved on: 
Monday, October 30, 2023

Dr. Daver is the lead investigator on Aptose’s APTIVATE trial of tuspetinib and is recognized for significant achievements in the development of novel acute myeloid leukemia (AML) treatments, including several combination therapies.

Key Points: 
  • Dr. Daver is the lead investigator on Aptose’s APTIVATE trial of tuspetinib and is recognized for significant achievements in the development of novel acute myeloid leukemia (AML) treatments, including several combination therapies.
  • Tuspetinib (TUS) is a once-daily, oral, precision targeted kinase inhibitor that suppresses select kinases that drive the proliferation of AML.
  • “We are really pleased by our growing safety and efficacy data on tuspetinib in very difficult-to-treat AML patient populations,” said Dr. Bejar.
  • “Data from the TUS/VEN doublet gives us confidence to move tuspetinib forward into a TUS/VEN/HMA triplet for the treatment of frontline newly-diagnosed AML patients.

KalVista Pharmaceuticals Presents Data on HAE Attacks in Patients Receiving Long-Term Prophylaxis at the Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2023 International Conference

Retrieved on: 
Tuesday, October 24, 2023

KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors, today announced the presentation of a novel analysis characterizing hereditary angioedema (HAE) attacks occurring in patients receiving long-term prophylaxis (LTP) treatments at the Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2023 International Conference (APAAACI) in Singapore.

Key Points: 
  • KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors, today announced the presentation of a novel analysis characterizing hereditary angioedema (HAE) attacks occurring in patients receiving long-term prophylaxis (LTP) treatments at the Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2023 International Conference (APAAACI) in Singapore.
  • A systematic literature review of interventional and observational LTP studies revealed that although LTP yields significant reductions in HAE attack frequency, many patients continue to experience attacks in all anatomic locations, including potentially life-threatening laryngeal attacks.
  • “As highlighted in HAE clinical practice guidelines, the goal of LTP is to achieve full control of disease burden.
  • “Access to safe and effective on-demand therapy is essential for all people living with HAE, including those receiving LTP.

6 ways universities can promote health on campus — and measure progress

Retrieved on: 
Monday, June 26, 2023

People’s physical and mental health were severely impacted by the sudden changes forced by the emergent global crisis.

Key Points: 
  • People’s physical and mental health were severely impacted by the sudden changes forced by the emergent global crisis.
  • Although global movements and organizations are dedicated to supporting universities’ work in health promotion, and many universities have committed to doing so, our research indicates that campuses struggle to promote health in a meaningful way.

Health promotion in universities

    • The movement to see universities promoting health was initially championed by the UK Healthy Universities Network.
    • 5 ways university students and faculty hope for better

      The framework was developed at the 2015 International Conference on Health Promoting Universities and Colleges held in Kelowna, B.C.

Health in all aspects of campus culture

    • The Okanagan Charter calls for embedding health into all aspects of campus culture and leading health promotion action and collaboration.
    • The Canadian Health Promoting Campuses Network assists Canadian campuses in the adoption of the charter.
    • All of these national networks are connected up to the International Health Promoting Universities and campuses.

Challenges with implementation

    • As the Okanagan Charter nears its 10th anniversary, questions remain about its limited adoption, its challenges with implementation and the progress made towards its calls to action.
    • Our research project, funded by the Social Sciences and Humanities Research Council, examined the adoption, implementation and evaluation of the charter at the first 10 Canadian campuses who signed onto the charter in 2016 and 2017: University of British Columbia, University of Saskatchewan, Simon Fraser University, University of Guelph, Mount Royal University, King’s University College, University of Lethbridge, Western University, University of Calgary and Memorial University.

Implementation left to a few people

    • The research uncovered that many of the first signatory campuses were struggling with taking action on many of their Charter commitments.
    • In many cases, after executive leadership signed the charter, the implementation was left to a few people working with few resources to design initiatives and follow progress.

Evaluation absent

    • Evaluation and assessment frameworks were especially absent at most campuses.
    • That finding has lead to our renewed concern: how are universities evaluating progress against broader health goals?

Well-resourced approaches

    • Universities need to work towards engaged leadership, deliberate actions, innovative and well-resourced approaches, networked opportunities and meaningful measures of progress.
    • If university leaders say that this work matters, that means they must elevate the profile of health and well-being on campus.
    • Some identifiable next steps can be: 1) Embed well-being in institutional strategic plans.
    • 3) Give stewards of the work resources, both financial and human, for relevant activities and initiatives.

Tessa Therapeutics Announces Positive Results from CD30 CAR-T Combination Study with Nivolumab in 2nd line Hodgkin Lymphoma

Retrieved on: 
Friday, June 16, 2023

TT11 is currently being investigated in combination with Nivolumab in Phase 1B (ACTION) study targeting R/R classical Hodgkin Lymphoma (cHL) patients after frontline therapy failure (NCT05352828).

Key Points: 
  • TT11 is currently being investigated in combination with Nivolumab in Phase 1B (ACTION) study targeting R/R classical Hodgkin Lymphoma (cHL) patients after frontline therapy failure (NCT05352828).
  • Study protocol involves patients being treated with 2 cycles of Nivolumab, followed by a single infusion of CD30.CAR-T preceded by lymphodepletion (LD) chemotherapy.
  • A total of 15 patients were enrolled of which 13 were treated with Nivolumab + CD30 CAR-T therapy.
  • These results offer the potential to re-define Hodgkin lymphoma treatment paradigm, offering a second line treatment alternative free of transplant and high dose chemotherapy to patients who fail frontline therapy,” said Thomas Willemsen, President and CEO, Tessa Therapeutics.

Latest Data of InnoCare’s Orelabrutinib Presented at the 17th International Conference on Malignant Lymphoma (ICML)

Retrieved on: 
Friday, June 16, 2023

InnoCare Pharma (HKEX: 09969; SSE: 688428), a leading biopharmaceutical company, today announced the latest clinical data of its Bruton Tyrosine Kinase (BTK) inhibitor orelabrutinib at the 17th International Conference on Malignant Lymphoma (ICML).

Key Points: 
  • InnoCare Pharma (HKEX: 09969; SSE: 688428), a leading biopharmaceutical company, today announced the latest clinical data of its Bruton Tyrosine Kinase (BTK) inhibitor orelabrutinib at the 17th International Conference on Malignant Lymphoma (ICML).
  • Among the enrolled Chinese patients, the majority had late-stage diseases, with the stage IV accounting for 75.9%.
  • The 12-month PFS rate was 84.3% and the rate of overall survival (OS) was 91.5% at 12 months.
  • The preliminary data indicated that the orelabrutinib plus lenalidomide and rituximab exerted synergistic antitumor activity, with a good safety profile in the treatment of MCL.

BeiGene Highlights Significant BRUKINSA® (zanubrutinib) Data at the 17th International Conference on Malignant Lymphoma

Retrieved on: 
Thursday, June 15, 2023

BeiGene (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global biotechnology company, today announced that it will present data on its Bruton’s tyrosine kinase inhibitor (BTKi) BRUKINSA® (zanubrutinib) at the 17th International Conference on Malignant Lymphoma (ICML), which is taking place from June 13-17 in Lugano, Switzerland.

Key Points: 
  • BeiGene (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global biotechnology company, today announced that it will present data on its Bruton’s tyrosine kinase inhibitor (BTKi) BRUKINSA® (zanubrutinib) at the 17th International Conference on Malignant Lymphoma (ICML), which is taking place from June 13-17 in Lugano, Switzerland.
  • View the full release here: https://www.businesswire.com/news/home/20230615000227/en/
    BeiGene Highlights Significant BRUKINSA® (zanubrutinib) Data at the 17th International Conference on Malignant Lymphoma - Mehrdad Mobasher, M.D., M.P.H., Chief Medical Officer, Hematology at BeiGene (Photo: Business Wire)
    “The data presented at ICML provide further evidence supporting our confidence in BRUKINSA.
  • The complete response rate for BRUKINSA in combination with obinutuzumab was 39.3% compared to 19.4% for obinutuzumab alone.
  • The most common grade ≥3 adverse events were neutropenia (23.1%), thrombocytopenia (7.7%), lung infection (5.8%) (Abstract #153)

Seagen Announces ADCETRIS® (brentuximab vedotin) Plus Novel Immunotherapy Combination Delivers 98% Overall Response Rate and 93% Complete Response Rate in Patients with Early-Stage Classical Hodgkin Lymphoma (cHL)

Retrieved on: 
Tuesday, June 13, 2023

Data results will be presented at the 17th International Conference on Malignant Lymphoma (ICML) in Lugano, Switzerland June 13-17.

Key Points: 
  • Data results will be presented at the 17th International Conference on Malignant Lymphoma (ICML) in Lugano, Switzerland June 13-17.
  • The study will be presented on June 17, 2023.
  • Immune-mediated AEs observed to date are consistent with the individual safety profile of nivolumab.
  • Please see Important Safety Information, including a BOXED WARNING for progressive multifocal leukoencephalopathy (PML), for ADCETRIS below.

Late-Breaking Data for Cytovale’s IntelliSep® Sepsis Test Further Validate its Potential to Aid in Rapid, Clinically Actionable Sepsis Diagnosis in Emergency Departments

Retrieved on: 
Monday, May 22, 2023

These data were presented for the first time today as a late-breaking poster presentation at the American Thoracic Society (ATS) International Conference in Washington, DC.

Key Points: 
  • These data were presented for the first time today as a late-breaking poster presentation at the American Thoracic Society (ATS) International Conference in Washington, DC.
  • “These results validate the efficacy and efficiency of IntelliSep as a diagnostic aid that may improve sepsis triage when incorporated into existing clinical protocols."
  • In this study, which included 572 patients, the IntelliSep test identified three statistically distinct bands of sepsis probability with an increasing likelihood of sepsis.
  • Cytovale anticipates making the IntelliSep test commercially available within the next quarter.

Bristol Myers Squibb’s Investigational LPA1 Antagonist Reduces the Rate of Lung Function Decline in Patients with Idiopathic Pulmonary Fibrosis

Retrieved on: 
Monday, May 22, 2023

Bristol Myers Squibb (NYSE: BMY) today announced results from a Phase 2 study evaluating BMS-986278, a potential first-in-class, oral, lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis.

Key Points: 
  • Bristol Myers Squibb (NYSE: BMY) today announced results from a Phase 2 study evaluating BMS-986278, a potential first-in-class, oral, lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis.
  • Pulmonary fibrosis is a devastating, life-threatening illness, with daily symptoms including coughing, labored breathing and extreme fatigue.
  • Dose reductions due to blood pressure criteria were implemented in 5% (placebo), 8% (30 mg) and 6% (60 mg) of patients.
  • A similar number of patients received dose reduction across the placebo (n=5), 30 mg (n=7) and 60 mg (n=6) treatment arms.

Dupixent® (dupilumab) Late-breaking Phase 3 COPD Results Presented at ATS and Simultaneously Published in the New England Journal of Medicine

Retrieved on: 
Sunday, May 21, 2023

TARRYTOWN, N.Y. and PARIS, May 21, 2023 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today presented positive Phase 3 results evaluating the investigational use of Dupixent® (dupilumab) compared to placebo in adults currently on maximal standard-of-care inhaled therapy (triple therapy) with uncontrolled chronic obstructive pulmonary disease (COPD) and evidence of type 2 inflammation. The Dupixent Phase 3 results were presented in the 2023 American Thoracic Society (ATS) International Conference session “New England Journal of Medicine and JAMA. Discussion on the Edge: Reports of Recently Published Pulmonary Research” and simultaneously published in the New England Journal of Medicine (NEJM). These results will also be presented in the “Breaking News: Clinical Trial Results in Pulmonary Medicine” session on May 22.

Key Points: 
  • The Dupixent Phase 3 results were presented in the 2023 American Thoracic Society (ATS) International Conference session “New England Journal of Medicine and JAMA.
  • Discussion on the Edge: Reports of Recently Published Pulmonary Research” and simultaneously published in the New England Journal of Medicine (NEJM).
  • These results will also be presented in the “Breaking News: Clinical Trial Results in Pulmonary Medicine” session on May 22.
  • The results presented at ATS and published in NEJM are from the BOREAS trial, which met the primary and all key secondary endpoints.