SCFA | Jotup

MaaT Pharma Presents Promising Preclinical Data at AACR for MaaT034 Aiming To Improve Patients’ Responses to Immunotherapies

Retrieved on:

Monday, April 8, 2024

Oncology, Health, FDA, Clinical Trials, Pharmaceutical, Biotechnology, Survival, Maat, Fatty acid, Patient, SCFA, Cancer, AACR, MET, Pharmaceutical industry

MaaT034, the first product from MaaT Pharma’s MET-C platform is a ground-breaking full ecosystem synthetic microbiota product, developed in combination with immune checkpoint inhibitors to improve treatment efficacy in large market solid tumor indications.

Key Points:

MaaT034, the first product from MaaT Pharma’s MET-C platform is a ground-breaking full ecosystem synthetic microbiota product, developed in combination with immune checkpoint inhibitors to improve treatment efficacy in large market solid tumor indications.
The MET-C platform enables MaaT Pharma to produce microbiome therapies at a large-scale to meet the needs of larger market indications.
The data published represents significant advancements in understanding the mechanism of action (MoA) of co-cultured microbiome therapies developed by MaaT Pharma, marking a major step towards clinical evaluation.
These findings support the role of MaaT034 in gut barrier repair and in T cell reactivation either in combination with Nivolumab (anti-PD1) or with Atezolizumab (anti-PD-L1).

IDTechEx Analysis: Emerging Molecules Produced Through Industrial Biomanufacturing

Retrieved on:

Tuesday, November 7, 2023

Within this diverse range, an emerging subset of molecules have attracted the interest of numerous companies, both well-funded startups and multinational corporations.

Key Points:

Within this diverse range, an emerging subset of molecules have attracted the interest of numerous companies, both well-funded startups and multinational corporations.
IDTechEx has analyzed over thirty-five different molecules and compounds in their market research report " White Biotechnology 2024-2034 "; here are some of the most interesting molecules whose biomanufacturing development is worth monitoring.
Polyamide precursors: one emerging category of biomanufactured molecules are key precursors for polyamides like PA 6 and PA 66.
These profiled molecules are just the tip of the iceberg when it comes to the new types of molecules being produced through white biotechnology.

IDTechEx Analysis: Emerging Molecules Produced Through Industrial Biomanufacturing

Retrieved on:

Tuesday, November 7, 2023

Within this diverse range, an emerging subset of molecules have attracted the interest of numerous companies, both well-funded startups and multinational corporations.

Key Points:

Within this diverse range, an emerging subset of molecules have attracted the interest of numerous companies, both well-funded startups and multinational corporations.
IDTechEx has analyzed over thirty-five different molecules and compounds in their market research report " White Biotechnology 2024-2034 "; here are some of the most interesting molecules whose biomanufacturing development is worth monitoring.
Polyamide precursors: one emerging category of biomanufactured molecules are key precursors for polyamides like PA 6 and PA 66.
These profiled molecules are just the tip of the iceberg when it comes to the new types of molecules being produced through white biotechnology.

GC Genome's New Study Reveals Link Between Gut Microbiome and High Blood Pressure

Retrieved on:

Thursday, June 15, 2023

YONGIN, South Korea, June 14, 2023 /PRNewswire/ -- GC Genome Corporation, a leading genomic diagnostics company, announced the publication of a study in Frontiers in Microbiomes. This study demonstrates the association between gut microbiome and Hypertension, underscoring the importance of the gut microbiome in relation to hypertension in collaboration with the research team at Kangbuk Samsung Hospital. It suggests that modifying dietary habits to alter enterotypes could serve as effective practical approach for managing and preventing hypertension. These findings carry potential implications for individuals seeking to improve their cardiovascular health.

Key Points:

This study demonstrates the association between gut microbiome and Hypertension, underscoring the importance of the gut microbiome in relation to hypertension in collaboration with the research team at Kangbuk Samsung Hospital.
And recent studies suggest that gut bacteria play a role in regulating blood pressure," said Ju Sun Song, MD, Senior director of the research institute at GC Genome.
Hypertension, commonly known as high blood pressure, is a global health concern affecting an estimated 1.13 billion individuals worldwide, as reported by the World Health Organization (WHO).
Further investigation is needed to fully understand the interaction of gut microbiome with the food we eat and our health.

Global Microbiome Sequencing Services Market Report 2023: High Cost of Advanced Infrastructure for Sequencing Fuels the Sector

Retrieved on:

Tuesday, May 30, 2023

DUBLIN, May 29, 2023 /PRNewswire/ -- The "Global Microbiome Sequencing Services Market by Service (Sample Preparation, Sequencing, Library Preparation), Type (Amplicon Sequencing, Whole Genome Sequencing), Technology (Sequencing by Synthesis, Nanopore Sequencing), End User - Forecast to 2028" report has been added to ResearchAndMarkets.com's offering.

Key Points:

DUBLIN, May 29, 2023 /PRNewswire/ -- The "Global Microbiome Sequencing Services Market by Service (Sample Preparation, Sequencing, Library Preparation), Type (Amplicon Sequencing, Whole Genome Sequencing), Technology (Sequencing by Synthesis, Nanopore Sequencing), End User - Forecast to 2028" report has been added to ResearchAndMarkets.com's offering.
Microbiome sequencing is expanding its applications beyond research and is increasingly being utilized in therapeutics development, including the study of the skin microbiome and oral microbiome sequencing.
Based on service, the microbiome sequencing services market is segmented into sample preparation services, sequencing and library preparation services, and data analysis services.
Based on technology, the global microbiome sequencing services market is segmented into sequencing by synthesis (SBS), sequencing by ligation (SBL), nanopore sequencing, and other technologies.

NutriLeads’ BeniCaros Strengthens Healthy Gut Microbiota, Study Shows

Retrieved on:

Tuesday, May 2, 2023

WAGENINGEN, the Netherlands, May 02, 2023 (GLOBE NEWSWIRE) -- An ex vivo study has demonstrated that BeniCaros®, an upcycled soluble carrot fiber from NutriLeads BV, has the right level of structural complexity to produce consistent, significant and beneficial effects on the gut microbiota despite differences in individual microbiota composition. This unique precision prebiotic robustly stimulated growth of common beneficial gut bacteria, significantly increased metabolite production and ultimately created a more consistent gut microbiota composition among healthy subjects. The results were recently published in the peer-reviewed journal, Nutrients.

Key Points:

This unique precision prebiotic robustly stimulated growth of common beneficial gut bacteria, significantly increased metabolite production and ultimately created a more consistent gut microbiota composition among healthy subjects.
“Variability in the gut microbial communities in individuals renders it challenging to demonstrate efficacy of functional ingredients.
This innovative technology enabled analysis of 24 individuals compared with conventional microbiota study methodologies that involve few subjects.
A common limitation of prebiotics when large daily serving sizes (10-20 grams) are recommended is that they may cause bloating, gas and gut discomfort in sensitive people.

Metabolon Launches Bile Acids and Short Chain Fatty Acids Targeted Panels to Advance Understanding of Microbiome and Gut Metabolome in Health and Disease

Retrieved on:

Tuesday, April 4, 2023

MORRISVILLE, N.C., April 4, 2023 /PRNewswire/ -- Metabolon, Inc., the global leader in providing metabolomics solutions that advance a wide variety of research, diagnostic, therapeutic development, and precision medicine applications, today announced the launch of its Bile Acids and Short Chain Fatty Acids Targeted Panels that measure microbially-derived metabolites of biological significance to identify biomarkers for the prediction and early detection of disease areas, including oncology, neurology, liver, diabetes, and gastrointestinal, and gut health.

Key Points:

Short Chain Fatty Acids (SCFAs) are produced in the colon by the gut microbiota and are the end products of the anaerobic fermentation of dietary fibers and protein/peptides in the small intestine.
Metabolon's Bile Acids Targeted Panel measures 21 metabolites and has been designed specifically to advance pre-clinical research identifying bile-acid related biomarkers in digestive, metabolic, and neurological health.
"Metabolon is committed to advancing scientific understanding of the human microbiome and its impact on human health.
Our Bile Acids and Short Chain Fatty Acids Targeted Panels address an important need for today's cutting-edge researchers and will help unlock new insights into the complex interplay between diet, gut health, and disease, paving the way for the development of more personalized, targeted therapies."

Noster Microbiome research: Fibrous fuel: Prebiotic fibers can keep the body's metabolism in check to improve gut-environment and suppress obesity

Retrieved on:

Thursday, March 23, 2023

Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.

Key Points:

Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.
A complementary food group known as prebiotics (mainly fibrous foods) serve as fuel for these bacteria to thrive.
Lactic acid bacteria, such as Leuconostoc mesenteroides (L. mesenteroides), are used in the fermentation process of fermented foods such as kimchi, sauerkraut, and pickles.
The researchers thus focused their study on the potential role of LmEPS as a prebiotic fiber.

Noster Microbiome research: Fibrous fuel: Prebiotic fibers can keep the body's metabolism in check to improve gut-environment and suppress obesity

Retrieved on:

Thursday, March 23, 2023

Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.

Key Points:

Probiotic foods such as miso and kimchi are rich in bacteria that keep the gut and body healthy.
A complementary food group known as prebiotics (mainly fibrous foods) serve as fuel for these bacteria to thrive.
Lactic acid bacteria, such as Leuconostoc mesenteroides (L. mesenteroides), are used in the fermentation process of fermented foods such as kimchi, sauerkraut, and pickles.
The researchers thus focused their study on the potential role of LmEPS as a prebiotic fiber.

ClostraBio Announces Breakthrough Publication Describing Targeted Delivery of Metabolite to Gastrointestinal Tract via Oral Nanoparticles; Appoints CEO

Retrieved on:

Tuesday, January 24, 2023

ClostraBio, a biotech company focused on developing novel therapeutic solutions for diseases of the gut, is excited to announce a major breakthrough in targeted metabolite delivery to transform intestinal health.

Key Points:

ClostraBio, a biotech company focused on developing novel therapeutic solutions for diseases of the gut, is excited to announce a major breakthrough in targeted metabolite delivery to transform intestinal health.
This first-in-class, oral, targeted metabolite delivery platform enables butyrate to achieve its maximum therapeutic potential with an initial focus on helping patients who struggle with gastrointestinal issues like mild to moderate ulcerative colitis and food allergies.
ClostraBio co-founder, Dr. Jeffrey Hubbell said, “In today’s options for gastrointestinal issues, targeted drug delivery has become key in pharmaceutical product development.
ClostraBio is a late-preclinical stage biopharma company focused on targeted metabolite delivery to transform intestinal health in patients with inflammatory bowel disease (IBD) and food allergy.