Feinstein Institutes for Medical Research

Northwell Health Commits $1M to Fund Employee Ideas for Healthcare Innovation During Big Ideas Showcase

Retrieved on: 
Monday, May 8, 2023
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Northwell Health has awarded $1 million toward the research and development of two employee-driven projects that drive the goal of transforming the future of health care with new ideas during the health system’s 2023 Innovation Challenge.

Key Points: 
  • Northwell Health has awarded $1 million toward the research and development of two employee-driven projects that drive the goal of transforming the future of health care with new ideas during the health system’s 2023 Innovation Challenge.
  • Winners of the competition included team leads hailing from the Feinstein Institutes for Medical Research , the home of research at Northwell Health.
  • The announcement was made during the health system’s Made for Big Ideas™ Showcase.
  • To date, Northwell has awarded funding for 13 projects to advance their progress and develop their innovative ideas.

Feinstein Institutes awarded $3.4M from Wellcome to study schizophrenia using rTMS therapy

Retrieved on: 
Friday, April 28, 2023
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Researchers at The Feinstein Institutes for Medical Research have received a $3.4 million grant from Wellcome to study repetitive transcranial magnetic stimulation (rTMS) and its effects.

Key Points: 
  • Researchers at The Feinstein Institutes for Medical Research have received a $3.4 million grant from Wellcome to study repetitive transcranial magnetic stimulation (rTMS) and its effects.
  • View the full release here: https://www.businesswire.com/news/home/20230428005023/en/
    Dr. Anil Malhotra will lead a new double-blind, randomized clinical trial that will study if rTMS improves social cognitive performance of people living with schizophrenia over the course of five years.
  • (Credit: Feinstein Institutes)
    Already approved by the U.S. Food and Drug Administration (FDA), rTMS is used to help treat people with depression and obsessive-compulsive disorder (OCD).
  • This is the first time the Feinstein Institutes received funding from Wellcome, a London-based charitable foundation which focuses on funding health research.

Elicio Therapeutics Announces First Patient Dosed in Phase 1/2 Study of Lymph Node-Targeted Investigational Therapeutic Vaccine ELI-002 7P (AMPLIFY-7P) in KRAS/NRAS Mutated Solid Tumors

Retrieved on: 
Thursday, April 27, 2023
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ELI-002 7P is an investigational therapeutic cancer vaccine that was created with Elicio’s proprietary lymph node-targeting Amphiphile (AMP) technology to treat cancers driven by seven common mutations in KRAS representing 25% of all solid tumors.

Key Points: 
  • ELI-002 7P is an investigational therapeutic cancer vaccine that was created with Elicio’s proprietary lymph node-targeting Amphiphile (AMP) technology to treat cancers driven by seven common mutations in KRAS representing 25% of all solid tumors.
  • Most other KRAS-targeted therapeutics in development — particularly small molecule KRAS inhibitors — target fewer mutations, potentially limiting the number of patients that can be treated.
  • In pancreatic ductal adenocarcinoma (PDAC) patients who have positive circulating tumor DNA (ctDNA) post-surgery, relapse occurs in 80%–85% of cases despite ‘curative’ resection with a median time of 9.9 months to recurrence.
  • In colorectal cancer (CRC) patients who have positive ctDNA post-surgery, radiologic recurrence was detected in approximately 79% of cases with a Kaplan Meier estimate of 0% survival at 3 years.

Feinstein Institutes researchers find brainstem neurons regulate pancreatic inflammation

Retrieved on: 
Tuesday, April 25, 2023
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In new research, scientists at The Feinstein Institutes for Medical Research have shown the ability to reduce pancreatic inflammation by stimulating the vagus nerve using optogenetics, or light.

Key Points: 
  • In new research, scientists at The Feinstein Institutes for Medical Research have shown the ability to reduce pancreatic inflammation by stimulating the vagus nerve using optogenetics, or light.
  • After stimulating the neurons in the DMN, researchers observed significantly less severe pancreatitis – as noted by a reduction in pancreatic cytokines, inflammatory proteins, tissue damage, and other signs.
  • These results provide the first evidence that efferent vagus cholinergic neurons originating in the brainstem DMN can inhibit pancreatic inflammation and point to a potential therapeutic target.
  • At the Feinstein Institutes, medical researchers use modern technology to develop new device-based therapies to treat disease and injury.

Non-invasive ultrasound stimulation of the spleen reduces inflammation in humans, new results from a clinical trial

Retrieved on: 
Monday, April 24, 2023
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Results from human studies published in the journal Brain Stimulation point to the possibility of using bioelectronic medicine and neuromodulation to treat inflammatory diseases traditionally treated only with drugs.

Key Points: 
  • Results from human studies published in the journal Brain Stimulation point to the possibility of using bioelectronic medicine and neuromodulation to treat inflammatory diseases traditionally treated only with drugs.
  • Sangeeta Chavan (left) and Stavros Zanos (right) helped lead the new study which published in the journal Brain Stimulation.
  • In 2021, the Feinstein Institutes and GE Research team showed the anti-inflammatory effects of liver-focused ultrasound on obesity in preclinical models.
  • Chavan and Zanos, along with GE Research and other collaborators, showed the ability of ultrasound to reverse diabetes in preclinical studies.

Neuvotion Secures an Additional $1.25M to Commercialize NeuStim™ Technology for Treating Stroke and Debilitating Injuries

Retrieved on: 
Thursday, April 13, 2023
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Northwell Holdings, the venture investment arm of Northwell Health, Topspin Fund, and Long Island Angel Network also participated in the round.

Key Points: 
  • Northwell Holdings, the venture investment arm of Northwell Health, Topspin Fund, and Long Island Angel Network also participated in the round.
  • This funding will be used by Neuvotion to further expand its team, complete clinical studies, and obtain FDA clearance for its initial product.
  • Neuvotion is also proud to continue their work with Intelligent Product Solutions (IPS) and Contract Engineering and Manufacturing (CEM) to bring Neuvotion's products to market.
  • "This technology has the potential to open new doors to regained independence and recovery for those facing difficult neurological conditions and injuries."

Philips and Northwell Health partner to standardize and future-proof patient monitoring across the enterprise

Retrieved on: 
Tuesday, April 4, 2023
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This will not only allow Northwell Health to lay the foundation for a future-proof, enterprise-wide platform, but the system will also allow them to support innovative technologies as they evolve and give them the flexibility to scale their patient monitoring systems quickly and efficiently.

Key Points: 
  • This will not only allow Northwell Health to lay the foundation for a future-proof, enterprise-wide platform, but the system will also allow them to support innovative technologies as they evolve and give them the flexibility to scale their patient monitoring systems quickly and efficiently.
  • Northwell Health is also pioneering research at the Feinstein Institutes, including national clinical trial sites for treating lupus, rheumatoid arthritis, and paralysis.
  • “The new Philips system gives us an enterprise-wide platform that centralizes our patient monitoring and allows us to see what is happening at each bedside.
  • With the Philips patient monitoring platform, they have a vendor-agnostic system that will leverage the health system’s existing network infrastructure, along with Philips Software Evolution Services, to standardize care and ensure that Northwell Health is at the forefront of monitoring innovation.

Tivic, The Feinstein Institutes for Medical Research Announce Pilot Study to Test Novel Non-Invasive Bioelectronic Approach to Vagus Nerve Stimulation

Retrieved on: 
Thursday, April 13, 2023
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Tivic Health® Systems, Inc. (“Tivic”) (Nasdaq: TIVC), a commercial-phase health technology company that develops and commercializes bioelectronic medicine, today announced a research collaboration with The Feinstein Institutes for Medical Research to conduct a pilot clinical study that will test a novel non-invasive bioelectronic device approach for vagus nerve stimulation.

Key Points: 
  • Tivic Health® Systems, Inc. (“Tivic”) (Nasdaq: TIVC), a commercial-phase health technology company that develops and commercializes bioelectronic medicine, today announced a research collaboration with The Feinstein Institutes for Medical Research to conduct a pilot clinical study that will test a novel non-invasive bioelectronic device approach for vagus nerve stimulation.
  • “Establishing on- and off-target effects of non-invasive vagal stimulation remains a major goal in the field of bioelectronic medicine,” said Theodoros Zanos, Ph.D., associate professor in the Institute of Bioelectronic Medicine at the Feinstein Institutes for Medical Research.
  • “Refinement of the strategies used to stimulate the vagus nerve non-invasively could be an important step in validating a novel approach to the treatment of autonomic conditions.
  • “The Feinstein Institutes is the internationally recognized leader in pioneering bioelectronic medicine research,” said Jennifer Ernst, CEO at Tivic.

NIH Awards $4.7M to Cohen Children’s Medical Center, Feinstein Institutes to Study Nephrotic Syndrome in Children

Retrieved on: 
Wednesday, April 5, 2023
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View the full release here: https://www.businesswire.com/news/home/20230405005701/en/

Key Points: 
  • View the full release here: https://www.businesswire.com/news/home/20230405005701/en/
    Christine Sethna, MD, was awarded two different grants to study how vagus nerve stimulation could help children with kidney disease.
  • Children with nephrotic syndrome are exposed to prolonged courses of steroids and other immunosuppressant medications which could have adverse effects.
  • The observational study will examine the nighttime blood pressure and cardiovascular outcomes in children with nephrotic syndrome at 22 different centers.
  • At the Feinstein Institutes, medical researchers use modern technology to develop new device-based therapies to treat disease and injury.

Feinstein Institutes researchers use novel imaging technology to study how the brain and body communicate

Retrieved on: 
Tuesday, March 21, 2023
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By using calcium imaging technology to monitor neural activity from a cluster of neurons near the base of the skull, scientists hope to discover new clues about how the body communicates with the brain.

Key Points: 
  • By using calcium imaging technology to monitor neural activity from a cluster of neurons near the base of the skull, scientists hope to discover new clues about how the body communicates with the brain.
  • The researchers used imaging of the intact jugular-nodose ganglion – which contains the sensory neurons of the vagus nerve – to directly record neural activity in mice with genetically-encoded calcium indicators.
  • In this new study, Feinstein Institutes’ bioelectronic medicine researchers look at how sensory neurons encode and transmit these important physiological signals in the form of neural activity.
  • At the Feinstein Institutes, medical researchers use modern technology to develop new device-based therapies to treat disease and injury.