Oxidative stress

Country Life® Vitamins Unveils Ageless Theory™: A Revolutionary Approach to Healthy Aging

Retrieved on: 
Tuesday, February 6, 2024
Ageless, Multimedia, Lipid, Life, Milk, Advanced glycation end-product, Wind, DNA, Regeneration, Country Life, Ageing, Overalls, Vitamin D, Carnosine, Collection, Marketing, Nutrient, Dicarboxylic acid, AVA, Stem cell, Food, Selenium, Protein, Disease, NSF, Health, Oxidative stress, GFCO, Dietary supplement

HAUPPAUGE, N.Y., Feb. 6, 2024 /PRNewswire-PRWeb/ -- Country Life® Vitamins, a pioneer in nutritional supplements, introduces Ageless Theory™, a groundbreaking line of health supplements representing the latest scientific advances in healthy aging. As demographics shift, with projections indicating that the world's population aged 60 and older will nearly double by 2050(1), Ageless Theory™ emerges as a proactive solution to nourish, support, and renew individuals' whole body health as they age.

Key Points: 
  • "At Country Life, we believe that everyone deserves the benefits of healthy aging.
  • Ageless Theory™ represents the latest scientific advances in healthy aging supplements, with a proven commitment to purity, efficacy, and sustainability.
  • The new line encapsulates the cleanest, most effective, natural ingredients to support healthy aging from within.
  • Sharon Paguio, senior director of marketing for the Country Life brand, says, "At Country Life, we believe that everyone deserves the benefits of healthy aging.

ZyVersa Therapeutics Highlights Publication Indicating That Inflammasome NLRP3-Mediated Inflammation in Obese Children Leads to Insulin Resistance and Risk of Complications Such as Type 2 Diabetes

Retrieved on: 
Wednesday, January 31, 2024
ROS, Inflammation, Uric acid, Insulin resistance, Research, Obesity, Cardiovascular disease, Glucose, Type, OGTT, Hypertension, ASC, Therapy, Journal of Translational Medicine, Risk, Journal, Type 2 diabetes, Serum, Translational medicine, NLRP3, Oxidative stress, Inflammasome, Pharmaceutical industry

ZyVersa is developing Inflammasome ASC Inhibitor IC 100 which inhibits NLRP3 and other types of inflammasomes and their associated ASC specks to attenuate initiation and perpetuation of damaging inflammation.

Key Points: 
  • ZyVersa is developing Inflammasome ASC Inhibitor IC 100 which inhibits NLRP3 and other types of inflammasomes and their associated ASC specks to attenuate initiation and perpetuation of damaging inflammation.
  • In the paper titled, “Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance,” the authors conducted a case-controlled study of 132 children who were either lean or obese.
  • The authors concluded, “It is insulin response to an OGTT that identifies children with obesity suffering oxidative stress, and inflammasome activation more specifically.
  • “The research published in the Journal of Translational Medicine points to a significant role for inflammasome-mediated inflammation and oxidative stress in development of metabolic complications in obese children.

EyePromise Launches Brain Health Supplement, BrainPromise™ by EyePromise®

Retrieved on: 
Friday, February 2, 2024
Antioxidant, Mineral, Lutein, Entrepreneurship, Doctor of Philosophy, Patient, Oxidative stress, Eye, Brain, Medical imaging

ST. LOUIS, Feb. 2, 2024 /PRNewswire/ -- Nutritional supplement leader, EyePromise has entered the brain health category with the launch of BrainPromise by EyePromise, a new product formulated for brain health, performance, and protection. BrainPromise offers comprehensive brain nutrition with essential vitamins and minerals including the antioxidants, zeaxanthin and lutein, which are featured in a plethora of published studies for their effectiveness in fighting oxidative stress among numerous other benefits.

Key Points: 
  • ST. LOUIS, Feb. 2, 2024 /PRNewswire/ -- Nutritional supplement leader, EyePromise has entered the brain health category with the launch of BrainPromise by EyePromise , a new product formulated for brain health, performance, and protection.
  • On creating a brain health supplement after three decades of researching and developing eye health products, EyePromise Chairman and Co-Founder, Dennis Gierhart, PhD said, "We have been researching the effects of protective carotenoids on the eye for many years, which provided a unique window into the brain.
  • As the eyes are an extension of the brain, it turns out what is good for the eyes is also good for the brain.
  • Zeaxanthin and lutein protect tissue from oxidative stress and offer many benefits to the brain including long-term brain health and brain function, improved recall, staying on task longer, among many others.

Uncle Matt's Organic® Launches Ultimate Athlete®

Retrieved on: 
Tuesday, January 23, 2024
Fruit, Electrolyte, Potassium, Organic, Denver Broncos, Oxidative stress, Pesticide, Ginger, Caffeine, Asthma, Sodium, Stroke, Innovation, Shot, Sport, Vitamin C, Muscle soreness, OJ, Inflammation, Orange juice, SRP, Marketing, Genetically modified organism, Soft drink

"We wanted to create a great-tasting pre-workout shot that would support sports and fitness goals without chemicals or caffeine -- Uncle Matt's Organic® Ultimate Athlete® Shot is delicious and organic, but just as effective as the mainstream shots out there," said Susan McLean, VP of Marketing and Innovation at Uncle Matt's Organic. "This innovation is a great addition to our Ultimate Shots line and is the perfect option for the pro athlete to the weekend warrior and everyone in between looking to help boost athletic performance with organic and multi-functional ingredients," she continued.

Key Points: 
  • CLERMONT, Fla., Jan. 23, 2024 /PRNewswire/ -- Uncle Matt's Organic ®, the nation's #1 selling brand of organic orange juice, announces today the launch of Uncle Matt's Organic® Ultimate Athlete® Pre-Workout Shot, aimed to boost athletic performance, hydrate and reduce oxidative stress—all in one gulp.
  • Uncle Matt's Organic® Ultimate Athlete® Shot starts with the highest quality OJ, using only 100% organically grown fruit that is free from synthetic fertilizers, pesticides, and GMOs.
  • Uncle Matt's Organic® Ultimate Athlete® Shot is available now at https://shop.UncleMatts.com with more store announcements being communicated through the brand's social channels in the coming weeks.
  • A Case of 6 - 2 oz shots is $24 when you buy direct from Uncle Matt's Organic®.

Eisai Furthers Oncology Research Across Multiple Cancers at ASCO GI and ASCO GU 2024

Retrieved on: 
Tuesday, January 16, 2024
MSD, PRISM, Renal cell carcinoma, Hypoxia, Patient, HCC, Research, Neoplasm, Meta-analysis, Oxidative stress, Rescue coordination centre, RCC, Merck & Co., ASCO, Cell lineage, Everolimus, Society, Pembrolizumab, Headquarters, FGFR2, Deep, Cholangiocarcinoma, Drug discovery, Hepatocellular carcinoma, Cancer, Food, Proteostasis, CBP, Safety, Abstract, Food and Drug Administration, FDA, Inflammation, CREB-binding protein, Biomarker, LEAP, TKI, Merck, Differentiable function, Pharmaceutical industry

TOKYO, Jan 16, 2024 - (JCN Newswire) - Eisai Co., Ltd. announced today the presentation of oncology research at two upcoming medical meetings taking place in-person in San Francisco, California and virtually.

Key Points: 
  • TOKYO, Jan 16, 2024 - (JCN Newswire) - Eisai Co., Ltd. announced today the presentation of oncology research at two upcoming medical meetings taking place in-person in San Francisco, California and virtually.
  • First, the company will share findings in hepatocellular carcinoma (HCC) and cholangiocarcinoma during the 2024 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium (#GI24), which is taking place from January 18-20.
  • Tasurgratinib, for which a marketing authorization application was submitted in Japan in December 2023, is an orally available selective tyrosine kinase inhibitor of FGFR1-3.
  • Eisai aspires to discover innovative new drugs with new targets and mechanisms of action from these domains, with the aim of contributing to the cure of cancers.

Combination Therapy and Precision Medicine Spotlighted as the Gold Standard for the Next Generation of Alzheimer's Treatments in the Journal of Prevention of Alzheimer's Disease (JPAD)

Retrieved on: 
Tuesday, January 16, 2024
Fillit, Entrepreneurship, Drug, School, Patient, Biology, Risk, Reno 1868 FC, Science, Research, MD, Oxidative stress, Next Generation, Biomarker, Drug development, Internal medicine, University, Geriatrics, Cancer, Ageing, Neuroprotection, UNLV, Journal, Karolinska Institute, Doctor of Science, Medicine, Autophagy, Therapy, Doctor of Philosophy, Syndrome, IHU, Dementia, Pharmaceutical industry

NEW YORK, Jan. 16, 2024 /PRNewswire/ -- The Journal of Prevention of Alzheimer's Disease (JPAD) with the support of the Alzheimer's Drug Discovery Foundation (ADDF) recently published a comprehensive issue, "The Biology of Aging: Leading The Next Generation of Alzheimer's Drug Development With a Geroscience Focus," which supports the consensus that combination therapy and precision medicine are the future of Alzheimer's treatment. This landmark publication arrives at a critical time in the Alzheimer's research field following significant drug breakthroughs of anti-amyloid therapies and the emergence of the biology of aging as the leading approach for drug development. This issue emphasizes the need to advance new therapies that target the underlying biology of the disease while also offering a roadmap for the next generation of Alzheimer's therapies.

Key Points: 
  • This issue emphasizes the need to advance new therapies that target the underlying biology of the disease while also offering a roadmap for the next generation of Alzheimer's therapies.
  • Each of these novel targets introduces a new and much-needed multi-pronged approach for developing Alzheimer's treatments, which can complement anti-amyloid drugs on the market.
  • The development of future therapies will enhance our growing understanding of the disease and how the various pathways interact to affect the disease state."
  • "This is a noteworthy achievement, as the publication will serve as the first extensive roadmap of non-amyloid pathways with the potential to address the complexity of Alzheimer's disease."

The curious link between animal hibernation and ageing – and what humans could learn from it

Retrieved on: 
Friday, January 5, 2024
Animal, Hibernation, Onion, Bread, Dementia, Protein, Metabolism, Life, Glass, Envy, Farmer, Man, Health, Metformin, Organ transplantation, DNA, Medical journal, Inflammation, Chronic kidney disease, Elephant, Lifestyle, Water, Type, Obesity, Food, The BMJ, Gene, Sleep, Radical, Oxidative stress, Longevity, Growth, Patient, Cardiovascular disease, Nature, Deficit spending, History, Flavonoid, Hunting

This long, deep rest is an example of how nature develops clever solution to difficult problems.

Key Points: 
  • This long, deep rest is an example of how nature develops clever solution to difficult problems.
  • In this case, how to survive a long, cold and dark period without much food and water.
  • You will also find descriptions in Inuit Greenlandic stories of a prolonged hibernation-like sleep during the long dark winter months.

Animals and hibernation

  • Animals that hibernate usually live longer compared to other species of the same size.
  • Recent studies using epigenetic clocks, which map activity within genes over time, suggest that hibernation slows down ageing in marmots and bats.
  • So hibernation may hold important clues on how to slow down ageing processes.
  • New science based on epigenetic clocks and lessons from hibernating animals could help us to treat patients who have diseases driven by “wear and tear”.
  • A 2018 study found that mimicking hibernation conditions for the storage of renal grafts from deceased donors seemed to improve their preservation.

Animals and longevity

  • It seems like protection against inflammation, oxidative stress and modifications of proteins that happen with age are mechanism that in general benefit all long-lived animals.
  • Genetic studies of rougheye rockfish, which can live for over 200 years, suggest that a food group called flavonoids is related to longevity.
  • Lessons from nature and hibernating animals tell us that preserving cells, regulation metabolism and genetic adaptions play key roles in longevity.

Forty winks

  • For example, a March 2023 study showed that with good quality sleep, you can add five years to the life of men and two and a half years if you are a woman.
  • How elephants can become so old while sleeping so little is still a mystery to scientists.


Peter Stenvinkel receives funding from Astra Zeneca, Fresenius, Baxter, Novo Nordisk, Bayer, Invizius, Vifor for lectures and scientific advisory boards

What humans can learn from animals about how to adapt to winter

Retrieved on: 
Friday, January 5, 2024
Animal, Hibernation, Onion, Bread, Dementia, Protein, Metabolism, Life, Glass, Envy, Farmer, Man, Health, Metformin, Organ transplantation, DNA, Medical journal, Inflammation, Chronic kidney disease, Elephant, Lifestyle, Water, Type, Obesity, Food, The BMJ, Gene, Sleep, Radical, Oxidative stress, Longevity, Growth, Patient, Cardiovascular disease, Nature, Deficit spending, History, Flavonoid, Hunting

When the cold and dark winter is setting in, some of us envy animals that can hibernate.

Key Points: 
  • When the cold and dark winter is setting in, some of us envy animals that can hibernate.
  • In this case, how to survive a long, cold and dark period without much food and water.
  • You will also find descriptions in Inuit Greenlandic stories of a prolonged hibernation-like sleep during the long dark winter months.

Animals and hibernation

  • Animals that hibernate usually live longer compared to other species of the same size.
  • Recent studies using epigenetic clocks, which map activity within genes over time, suggest that hibernation slows down ageing in marmots and bats.
  • So hibernation may hold important clues on how to slow down ageing processes.
  • New science based on epigenetic clocks and lessons from hibernating animals could help us to treat patients who have diseases driven by “wear and tear”.
  • A 2018 study found that mimicking hibernation conditions for the storage of renal grafts from deceased donors seemed to improve their preservation.

Animals and longevity

  • It seems like protection against inflammation, oxidative stress and modifications of proteins that happen with age are mechanism that in general benefit all long-lived animals.
  • Genetic studies of rougheye rockfish, which can live for over 200 years, suggest that a food group called flavonoids is related to longevity.
  • Lessons from nature and hibernating animals tell us that preserving cells, regulation metabolism and genetic adaptions play key roles in longevity.

Forty winks

  • For example, a March 2023 study showed that with good quality sleep, you can add five years to the life of men and two and a half years if you are a woman.
  • How elephants can become so old while sleeping so little is still a mystery to scientists.


Peter Stenvinkel receives funding from Astra Zeneca, Fresenius, Baxter, Novo Nordisk, Bayer, Invizius, Vifor for lectures and scientific advisory boards

Healthy Extracts Launches First Anti-Aging Formulation, LONGEVITY

Retrieved on: 
Thursday, January 4, 2024
Marketing, Quercetin, Risk, Infection, Vitamin D, Health, Disease, Calcium, Ageing, OTCQB, Antioxidant, Osteoporosis, Oxidative stress, Longevity, Growth, Overalls, K2, Skin, Dietary supplement

In celebration of the launch, for a limited time you can buy two and get one free .

Key Points: 
  • In celebration of the launch, for a limited time you can buy two and get one free .
  • “LONGEVITY Anti-Aging complements our growing heart health product portfolio which supports a holistic approach to anti-aging like healthy skin,” noted Healthy Extracts president, Duke Pitts.
  • LONGEVITY Anti-Aging is your ally for overall longevity, blending ingredients renowned for their anti-aging benefits that support a longer, healthier life.
  • To learn more about Healthy Extracts’ full line of clinically-backed, natural brain and hearth health products, go to bergametna.com or tryubn.com .

InFlectis BioScience Awarded $943,000 Grant from the ALS Association to Advance Ongoing ALS Clinical Trial with the Support of IRCCS Carlo Besta Neurological Institute

Retrieved on: 
Wednesday, January 3, 2024
ALS, Carlo Besta Neurological Institute, INN, Trial of the century, IRCCS, ALS Association, Biomarker, Oxidative stress, NMDAR, Patient, Pharmaceutical industry

The trial is investigating IFB-088 (INN: icerguastat), a multifunctional drug that modulates the PPP1R15A/PP1c phosphatase complex and inhibits NR2B-containing NMDAR.

Key Points: 
  • The trial is investigating IFB-088 (INN: icerguastat), a multifunctional drug that modulates the PPP1R15A/PP1c phosphatase complex and inhibits NR2B-containing NMDAR.
  • The potential of IFB-088 lies in its ability to target three major ALS cellular pathophysiological mechanisms to manage disease progression: protein aggregation, oxidative stress, and glutamate excitotoxicity.
  • InFlectis Bioscience has been awarded a $943K grant from the ALS Association to support the recruitment of 50 patients by the end of January 2024 for its Phase 2 clinical trial evaluating IFB-088.
  • The grant also supports a multi-omics approach, conducted by the IRCCS "Carlo Besta" Neurological Institute in Milan, Italy to investigate pharmacodynamic biomarker candidates, which will be useful in a future pivotal clinical study.