Dermis

Nature Publication Highlights the Benefits of Tropis® Intradermal When Used to Administer a First-in-Class Self-Amplifying mRNA Vaccine

Retrieved on: 
Wednesday, April 24, 2024

Furthermore, the publication cited that the self-amplifying, thermostable mRNA platform delivered intradermally with Tropis provides a framework for next-generation vaccines that can improve accessibility and global equity.

Key Points: 
  • Furthermore, the publication cited that the self-amplifying, thermostable mRNA platform delivered intradermally with Tropis provides a framework for next-generation vaccines that can improve accessibility and global equity.
  • View the full release here: https://www.businesswire.com/news/home/20240424868674/en/
    The PharmaJet pioneering technology unlocks the rich potential of the human dermis, paving the way for enhanced immune responses.
  • Vaccine delivery directly into the dermis enables access to the immune system, with benefits on durability and breadth of immune response, and mucosal immunity.
  • PharmaJet has over 80 global development partners and Tropis has been used to perform over 10 million vaccinations in several countries.

Somite Raises $5.3M As Five Leading Scientists Join Forces To Incorporate AI In Stem Cell Therapy

Retrieved on: 
Tuesday, April 16, 2024

BOSTON and AUSTIN, Texas, April 16, 2024 /PRNewswire/ -- Somite, a venture-backed company aiming to become the OpenAI of stem cell biology, announces that it has raised $5.3M in pre-seed funding. The round was led by Israel's preeminent Venture fund TechAviv, and joined by renowned Austin-based VCs Next Coast Ventures, Trust Ventures and Texas Venture Partners as well as NY-based Lerer Hippeau and others. The funds will be used to continue development of Somite's proprietary AlphaStem AI platform, building Somite labs and bringing the first therapeutic asset to phase 1 clinical trials. 

Key Points: 
  • The funds will be used to continue development of Somite's proprietary AlphaStem AI platform, building Somite labs and bringing the first therapeutic asset to phase 1 clinical trials.
  • Founded in October 2023, Somite is building AI foundation models to produce human tissue at scale for cell therapies.
  • "The future of medicine lies at the intersection of AI and biology," says Micha Breakstone, CEO and Co-Founder of Somite.
  • They are committed to advancing their groundbreaking stem cell therapy technology and have the power to transform the lives of millions of people by leveraging AI to produce human tissue for cell therapies."

Cervello and CO. Bringing Italian Artistry to Laser Engineering

Retrieved on: 
Monday, March 25, 2024

Lasers is proud to announce the launch of its new line of premium laser devices that blend elegant Italian design with cutting-edge laser technology.

Key Points: 
  • Lasers is proud to announce the launch of its new line of premium laser devices that blend elegant Italian design with cutting-edge laser technology.
  • Known for impeccable precision engineering and timeless Italian styling, Cervello is now taking its design-led approach to the next level.
  • Cervello laser hair removal device represents the pinnacle of Italian ingenuity.
  • At Cervello our advanced laser hair removal process employs a cutting-edge technique that combines precision pulse emission with a seamless gliding motion.

INTRODUCING BYOMA BODY

Retrieved on: 
Wednesday, March 13, 2024

NEW YORK, March 13, 2024 /PRNewswire/ -- BYOMA BODY is here to disrupt and democratize the bodycare category in the same way we revolutionized skincare – bringing best-in-class barrier care and skin-compatible science below the neck. This is accessible, affordable, and approachable barrier care for the rest of you – targeted, clinically efficacious, sensorial formulas for your best body.

Key Points: 
  • BYOMA Body is here to change that.
  • Skin does not have a uniform composition, so we are more likely to experience different issues on our body than on our faces.
  • BYOMA has carefully studied the science of skin – breaking down the barrier from the lipid layer to the microbiome.
  • This is a breakthrough in skin science that delivers the same level of care to your body as you show your face.

Your skin is a mirror of your health – here’s what yours might be saying

Retrieved on: 
Tuesday, January 30, 2024

It is the largest and most visible organ in the human body.

Key Points: 
  • It is the largest and most visible organ in the human body.
  • Being the most visible of our organs, the skin also offers us a view into the body tissues that it protects.
  • So don’t think of your skin merely aesthetically – think of it as a reflection of your health.

Bullseye

  • But while the vast majority of tick bites won’t make you ill, there is one rash that should prompt a visit to your doctor if you spot it.
  • Erythema migrans, a rash named for its ability to rapidly expand across the skin, is a hallmark of Lyme disease, a potentially severe bacterial illness.
  • This rash forms a classic target pattern, like a bullseye on a dartboard.

Purpura

  • Some rashes are given a colourful namesake – purpura is one such example.
  • Purpura refers to a rash of small purple or red dots.
  • Purpura signals an issue with either the walls of the tiny blood vessels that feed the skin or the blood within them.

Skin spiders


Skin rashes can also take on recognisable shapes. Spider naevi represent an issue within skin arterioles (small arteries which supply the skin with blood). Arterioles open and close to control the loss of heat from the body’s surface. But sometimes they can get stuck open – and a spider-like pattern will appear.

  • Crush the body under a fingertip and the whole thing disappears, as your touch temporarily stops the blood flow.
  • Treat the underlying cause, and the spiders often vanish with time – though they may persist or reappear later.

Black velvet

  • This “black velvet” skin appearance is more commonly seen in darker skins.
  • Usually, the condition is associated with disorders of the metabolism – namely type 2 diabetes and polycystic ovary syndrome.

Butterfly rashes

  • Cardiac valves have the important role of correctly directing the journey of blood through the heart and preventing backflow.
  • The body’s natural response is to preserve core blood volume, shutting off flow towards the skin.
  • The net effect can produce a purple-red rash, high across the cheeks and the bridge of the nose, like the outstretched wings of a butterfly.


Dan Baumgardt does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Thinking of a(nother) tattoo this summer? What you need to know about sunburn, sweating and fading

Retrieved on: 
Saturday, December 30, 2023

More of us have tattoos than ever before. About 25% of Australians are inked. A tattoo can be a large investment in time, money and pain. So how do you take care of your tattooed skin? Here’s what you need to know about sunburn, sweating and fading.

Key Points: 


More of us have tattoos than ever before. About 25% of Australians are inked. A tattoo can be a large investment in time, money and pain. So how do you take care of your tattooed skin? Here’s what you need to know about sunburn, sweating and fading.

Read more:
Tattoos have a long history going back to the ancient world – and also to colonialism

What’s a tattoo, dermatologically speaking?


Tattoo inks are deposited in the layer of skin called the dermis. This layer contains sweat and oil glands, a blood supply, immune cells, collagen to support the skin’s structures, and fibroblasts, which produce collagen.
Fibroblasts take up the ink particles, as do immune cells in the dermal tissue known as macrophages. The ink particles also stick inside bundles of collagen. Between these three mechanisms, the dermis holds tattoo inks so well they can be seen even on the 5,300-year-old ice mummy Ötzi.

Read more:
What Ötzi the prehistoric iceman can teach us about the use of tattoos in ceremonial healing or religious rites

Can I get a tattoo if I’m sunburnt?

  • During sunburn, your skin calls in extra immune cells and fluid to kill off and break down cells that have too much UV damage.
  • This inflammation can affect the tattoo ink deposits.

How soon after my new tattoo can I go into the sun?


There’s not much research on how soon you can expose your new tattoo to the sun. However, most tattooists advise you to avoid sun exposure while the tattoo heals, generally about three weeks. This seems sensible, as your fresh tattoo is a type of wound.

  • There is an influx of immune cells to deal with the damage, much like a sunburn.
  • So, in one way, you should treat your new tattoo like sunburn and avoid sun exposure while it heals.
  • But you shouldn’t use sunscreen on the tattoo in that time.

What happens if my tattoo gets sunburnt?

  • There’s usually swelling, itching or stinging on the tattoo site that can start immediately or develop over the course of a day.
  • There is also a small amount of evidence that sunburn on a tattoo temporarily suppresses the skin’s immune system, allowing an infection to become established.

Do tattoos increase my risk of skin cancer?

  • However, there’s no evidence skin cancers are more likely in tattooed skin.
  • Tattoos make newly-developed skin cancers more difficult to detect.
  • Red tattoos seem to be more prone to large but benign (non-cancerous) skin tumours called keratoacanthomas.
  • However, they can be difficult to distinguish from squamous cell carcinomas (a type of skin cancer).

Can sunlight fade my tattoo?

  • As tattoos age, they can fade a bit as some of the loose ink particles filter deeper into the dermis.
  • Sun exposure can also degrade ink particles.
  • After all, most people don’t want to fade their tattoos for science.

Does tattooed skin sweat differently to un-inked skin?

  • If you’ve got a full sleeve or your whole back is your canvas, that’s a significant amount of skin.
  • Since tattooing punctures the skin repeatedly, sweat glands in the dermis may be damaged.
  • However, when other researchers looked at sweating induced by exercise there was no effect in the volume of sweat between tattooed and un-tattooed skin.

Longer-term risks


When performed under the clean conditions of a licenced tattoo parlour, tattooing is relatively safe. But long term, some people develop allergic reactions to certain colours due to the different compounds in each, most commonly red dyes. This can cause lumps, scales, scarring or other visible changes. So, what’s the most common long-term side effect of tattoos? Tattoo regret and wanting to have them removed.
Katie Lee receives funding from the National Health and Medical Research Council. Erin McMeniman does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

RTI Surgical Inc. Receives FDA IDE Approval for the Clinical Investigation of Cortiva® Allograft Dermis in Breast Reconstruction

Retrieved on: 
Monday, November 27, 2023

ALACHUA, Fla., Nov. 27, 2023 /PRNewswire/ -- RTI Surgical, a leading global medical device organization, announced that the U.S. Food and Drug Administration (FDA) has granted Investigational Device Exemption (IDE) approval for a clinical study designed to confirm the safety and effectiveness of Cortiva® Allograft Dermis in implant-based breast reconstruction.

Key Points: 
  • ALACHUA, Fla., Nov. 27, 2023 /PRNewswire/ -- RTI Surgical, a leading global medical device organization, announced that the U.S. Food and Drug Administration (FDA) has granted Investigational Device Exemption (IDE) approval for a clinical study designed to confirm the safety and effectiveness of Cortiva® Allograft Dermis in implant-based breast reconstruction.
  • Olivier Visa, President and Chief Executive Officer of RTI Surgical, emphasized the company's commitment to advancing patient care by providing human acellular dermal matrix (ADM) for individuals undergoing breast reconstruction as part of their breast cancer treatment.
  • "This milestone marks a significant step towards obtaining FDA pre-market approval (PMA) for our Cortiva® allograft implants.
  • In consultation with the FDA, RTI Surgical developed a comprehensive clinical study to support its PMA application to obtain an indication for use in breast reconstruction.

Revelle Aesthetics Receives First International Clearance in Australia for its Avéli® Cellulite Device

Retrieved on: 
Tuesday, November 14, 2023

MOUNTAIN VIEW, Calif., Nov. 14, 2023 /PRNewswire/ -- Revelle Aesthetics, a VC-backed Silicon Valley FemTech company, today announced that Avéli®, its US FDA-cleared device for long-term reduction in the appearance of cellulite, has received its first international clearance in Australia, one of the largest market opportunities for cellulite outside of the United States.

Key Points: 
  • MOUNTAIN VIEW, Calif., Nov. 14, 2023 /PRNewswire/ -- Revelle Aesthetics , a VC-backed Silicon Valley FemTech company, today announced that Avéli®, its US FDA-cleared device for long-term reduction in the appearance of cellulite, has received its first international clearance in Australia, one of the largest market opportunities for cellulite outside of the United States.
  • "Cellulite is one of the most common skin conditions, prevalent in up to 90% of women1 worldwide.
  • "With our Australian clearance, we establish our global footprint and look forward to bringing a real cellulite solution to women around the world."
  • Avéli is a first-of-its-kind device that delivers a meaningful reduction in cellulite dimples after a single in-office procedure by treating cellulite at its source.

Scilex Holding Company Announces New Data From Deeper Skin Penetration Studies to Support SP-103 (lidocaine topical system) 5.4%, a Triple Strength Formulation of ZTlido®, in Treatment of Musculoskeletal Pain Disorders

Retrieved on: 
Thursday, November 2, 2023

A set of studies assessed drug delivery from SP-103, ZTlido and control (Pennsaid®, 2% diclofenac) using open flow microperfusion.

Key Points: 
  • A set of studies assessed drug delivery from SP-103, ZTlido and control (Pennsaid®, 2% diclofenac) using open flow microperfusion.
  • Interstitial fluid from the dermis, subcutaneous adipose tissue, and muscle was continuously sampled to assess drug penetration in all tissue layers.
  • Current results of skin penetration studies for the first time had demonstrated uptake of lidocaine by muscle tissue via a passive diffusion through the skin.
  • We are very excited about these results supporting our clinical development plans,” said Dmitri Lissin, MD, Chief Medical Officer at Scilex.

MTF Biologics® Receives First Investigational Device Exemption Approval for Human Acellular Dermal Matrix in Breast Reconstruction

Retrieved on: 
Tuesday, October 24, 2023

This marks the first IDE approval for a human acellular dermal matrix for breast reconstruction granted by FDA and is an important milestone in MTF Biologics pursuing Pre-Market Approval (PMA) for FlexHD® Pliable.

Key Points: 
  • This marks the first IDE approval for a human acellular dermal matrix for breast reconstruction granted by FDA and is an important milestone in MTF Biologics pursuing Pre-Market Approval (PMA) for FlexHD® Pliable.
  • “We are excited to embark on a PMA study for FlexHD® Pliable in breast reconstruction,” said Marc Long, Ph.D., executive vice president of research and development, clinical and medical affairs at MTF Biologics.
  • To support its PMA, MTF Biologics developed a clinical study in collaboration with the FDA to achieve an indication for use in breast reconstruction.
  • The study, which will launch in late 2024, will enroll patients undergoing mastectomy and implant-based breast reconstruction at U.S. institutions.