Stinger

Dermavant Announces FDA Acceptance of Supplemental New Drug Application (sNDA) for VTAMA® (tapinarof) Cream, 1% for the Treatment of Atopic Dermatitis in Adults and Children 2 Years of Age and Older

Retrieved on: 
Monday, April 29, 2024

The Prescription Drug User Fee Act ("PDUFA") action date assigned by the Agency is in Q4 2024.

Key Points: 
  • The Prescription Drug User Fee Act ("PDUFA") action date assigned by the Agency is in Q4 2024.
  • VTAMA cream is a novel, aryl hydrocarbon receptor agonist in development as a once-daily, cosmetically elegant, and steroid-free, topical cream for both acute treatment and long-term management of AD.
  • On May 24, 2022, Dermavant announced the FDA approved VTAMA® (tapinarof) cream, 1% for the treatment of plaque psoriasis in adults.
  • Indication: VTAMA® (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults.

Most bees don’t die after stinging – and other surprising bee facts

Retrieved on: 
Thursday, April 25, 2024

But maybe we also felt a tinge of regret, or vindication, knowing the offending bee will die.

Key Points: 
  • But maybe we also felt a tinge of regret, or vindication, knowing the offending bee will die.
  • Only eight out of almost 21,000 bee species in the world die when they sting.
  • To understand the intricacies of bees and their stinging potential, we’re going to need to talk about the shape of stingers, bee genitals, and attitude.

Our beloved, and deadly, honey bees

  • Native to Europe and Africa, these bees are today found almost everywhere in the world.
  • They are one of eight honey bee species worldwide, with Apis bees representing just 0.04% of total bee species.
  • We could say they die for queen and colony, but the actual reason these bees die after stinging is because of their barbed stingers.
  • Beyond that, bees and wasps (probably mostly European honey bees) are Australia’s deadliest venomous animals.

So what is a stinger?


A stinger, at least in most bees, wasps and ants, is actually a tube for laying eggs (ovipositor) that has also been adapted for violent defence. This group of stinging insects, the aculeate wasps (yes, bees and ants are technically a kind of wasp), have been stabbing away in self-defence for 190 million years. You could say it’s their defining feature.

  • The sting of the European honey bee is about as painful as a bee sting gets, scoring a 2 out of 4 on the Schmidt insect sting pain index.
  • On the flipside, most bee species can sting you as many times as they like because their stingers lack the barbs found in honey bees.

Can you tell who’s packing?


Globally, there are 537 species (about 2.6% of all bee species) of “stingless bees” in the tribe Meliponini. We have only 11 of these species (in the genera Austroplebeia and Tetragonula) in Australia. These peaceful little bees can also be kept in hives and make honey. Stingless bees can still defend their nests, when offended, by biting. But you might think of them more as a nuisance than a deadly stinging swarm.
Australia also has the only bee family (there are a total of seven families globally) that’s found on a single continent. This is the Stenotritidae family, which comprises 21 species. These gentle and gorgeous giants (14–19mm in length, up to twice as long as European honey bees) also get around without a functional stinger.
The astute reader might have realised something by this point in the article. If stingers are modified egg-laying tubes … what about the boys? Male bees, of all bee species, lack stingers and have, ahem, other anatomy instead. However, some male bees will still make a show of “stinging” if you try to grab them. Some male wasps can even do a bit of damage, though they have no venom to produce a sting.

Why is it always the honey bees?

  • So, if the majority of bees can sting, why is it always the European honey bee having a go?
  • First, the European honey bee is very abundant across much of the world.
  • So those hardworking European honey bees are really putting in the miles.

A complicated relationship

  • We have an interesting relationship with our European honey bees.
  • They can be deadly, are non-native (across much of the world), and will aggressively defend their nests.
  • Amy-Marie Gilpin receives funding from Western Sydney University and Horticulture Innovation Australia.
  • She is also a member of the IUCN Wild Bee Specialist Group Oceania.

Kopin Partners with BlueHalo for the Development of New Advanced Simulated Binoculars & Monoscope Products

Retrieved on: 
Tuesday, March 26, 2024

Kopin Corporation (NASDAQ: KOPN) a leading provider of application-specific optical solutions and high-performance micro-displays for defense, enterprise, consumer, and medical products, today announced it has been awarded a contract from BlueHalo LLC (BlueHalo) for the design, development, and production of advanced simulated binoculars and monoscope products for use in their Advanced Stinger Trainer (AST) system.

Key Points: 
  • Kopin Corporation (NASDAQ: KOPN) a leading provider of application-specific optical solutions and high-performance micro-displays for defense, enterprise, consumer, and medical products, today announced it has been awarded a contract from BlueHalo LLC (BlueHalo) for the design, development, and production of advanced simulated binoculars and monoscope products for use in their Advanced Stinger Trainer (AST) system.
  • Both products will significantly increase performance over those currently available in similar systems and add to Kopin’s well-established line of Training & Simulation products.
  • Kopin’s products, which are driven by a computer image generator, will incorporate a positional/directional tracking sensor to provide a realistic simulation of the equivalent fielded products.
  • We are pleased that Kopin is expanding our customer base with new partners like BlueHalo who has trusted Kopin with developing and producing these critical systems.”

KINDRA LAUNCHES FIRST-EVER COMPREHENSIVE VAGINAL HEALTH SYSTEM: THE DAILY V SYSTEM

Retrieved on: 
Monday, March 25, 2024

NEW YORK, March 25, 2024 /PRNewswire/ -- Today, Kindra, the sex-positive vaginal health brand, announced the launch of the first-ever comprehensive vaginal health product system - the Daily V System. The 4-part daily regimen of Kindra products includes: Daily Vaginal Lotion, V Relief Serum, Soothe Bath Soak and the Core Supplement meant to support vulvar and vaginal skin for optimal vaginal health and sexual wellness.

Key Points: 
  • NEW YORK, March 25, 2024 /PRNewswire/ -- Today, Kindra , the sex-positive vaginal health brand, announced the launch of the first-ever comprehensive vaginal health product system - the Daily V System .
  • The 4-part daily regimen of Kindra products includes: Daily Vaginal Lotion , V Relief Serum , Soothe Bath Soak and the Core Supplement meant to support vulvar and vaginal skin for optimal vaginal health and sexual wellness.
  • This hormone-free system is designed to provide targeted relief and support for daily vulvar and vaginal health needs.
  • As part of its launch of the Daily V System, Kindra has partnered with pelvic floor physical therapist Dr. Sara Reardon, known online as The Vagina Whisperer, on a video about the importance of a daily vaginal health regimen for long-term vulvovaginal health and comfort.

Dermavant to Present New ADORING Data Including Treatment of Patients with Skin of Color from Phase 3 Trials of VTAMA® (tapinarof) Cream, 1% in Adults and Children 2 Years of Age and Older with Atopic Dermatitis at the 2024 AAD Annual Meeting

Retrieved on: 
Friday, March 1, 2024

VTAMA cream is a novel, aryl hydrocarbon receptor agonist in development as a once-daily, cosmetically elegant, and steroid-free, topical cream for both acute treatment and long-term management of atopic dermatitis (AD).

Key Points: 
  • VTAMA cream is a novel, aryl hydrocarbon receptor agonist in development as a once-daily, cosmetically elegant, and steroid-free, topical cream for both acute treatment and long-term management of atopic dermatitis (AD).
  • VTAMA cream, 1% is currently approved for the topical treatment of plaque psoriasis in adults in the U.S. and is the same strength and formulation being studied in the ADORING Phase 3 development program for AD.
  • The following posters will be viewable onsite at the San Diego Convention Center.
  • Indication: VTAMA® (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults.

Sun Pharma Launches WINLEVI® (clascoterone) Cream 1% Connected TV (CTV) Ad Campaign with Dr. Sandra Lee (a.k.a. "Dr. Pimple Popper")

Retrieved on: 
Wednesday, March 6, 2024

WINLEVI is the first and only FDA-approved topical acne treatment available in the U.S. that targets sebum production in the skin.

Key Points: 
  • WINLEVI is the first and only FDA-approved topical acne treatment available in the U.S. that targets sebum production in the skin.
  • "We are thrilled to continue our collaboration with Dr. Sandra Lee, whose persona as 'Dr.
  • Pimple Popper' fits well with our use of humorous and relatable content to connect with teens.
  • Additionally, edema, stinging, and burning occurred in >3% of patients and were reported in a similar percentage of subjects treated with vehicle.

Domestic and international developments risk undermining Ukraine in a critical year

Retrieved on: 
Thursday, February 15, 2024

International attention, partially diverted by the war in Gaza, appears to be waning.

Key Points: 
  • International attention, partially diverted by the war in Gaza, appears to be waning.
  • Furthermore, domestic politics within Ukraine are threatening to undermine its war aims.

Russian morale

  • First, the Russian economy, while on a war footing, is not as strong as it appears.
  • The growth in the Russian economy shocked most analysts, but it was primarily due to armament production.
  • The precise effect of these casualties on Russian morale is debatable.
  • The Russian army has been relying on non-Russian minorities to fight the war, a policy that appears to be an effort to maintain Putin’s popularity among Russian nationalists.

The need for smarter aid

  • International aid was substantial early on as several states rushed to support Ukraine.
  • This aid provided both material necessities and a significant morale boost.
  • In the long term, however, the aid has proven problematic.

Justifying the expense of sending aid

  • In some ways, it actually proves detrimental, as it causes soldiers to turn away from areas and techniques that led to success.
  • The ongoing debates in the United States congress over providing aid to Ukraine partly reflect this issue.
  • Rather, it’s important to acknowledge the limitations of the aid provided so far to Ukraine.
  • Its importance is such that it’s influencing Ukrainian domestic politics, as Zaluzhnyi’s critical assessments on Ukraine’s needs finally provoked President Volodymyr Zelenskyy into action.

Domestic shakeups

  • This included replacing the popular Zaluzhnyi with Col.-Gen. Oleksandr Syrskyi, who previously served as commander of the Ukrainian ground forces.
  • Replacing Zaluzhnyi at such a critical juncture in the war signals to Ukraine’s allies that the war isn’t going well.
  • The question now is if the unity of message was worth losing a valuable wartime general.


James Horncastle does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Dr. Phil's Merit Street Media Announces Live Morning & Evening News Programming

Retrieved on: 
Thursday, January 25, 2024

Merit Street Media ™ , the upcoming news and entertainment cable broadcasting network founded by Dr. Phil McGraw, announces its first venture into live news programming.

Key Points: 
  • Merit Street Media ™ , the upcoming news and entertainment cable broadcasting network founded by Dr. Phil McGraw, announces its first venture into live news programming.
  • Both set to premiere on February 26, 2024, "Morning on Merit Street'' will be co-hosted by Dominique Sachse and Fanchon Stinger and "The News on Merit Street" will feature senior anchor Kris Gutierrez and co-hosts Lyndsey Keith and Loni Coombs.
  • "Morning on Merit Street" (Weekdays 8-10 AM ET) offers a fresh approach to morning news, combining information, enlightenment, entertainment, and inspiration.
  • "The News on Merit Street" (Weeknights 7-8 PM ET) takes a comprehensive approach to the top headlines of the day.

Allergy Immunotherapies Market to grow by USD 1.01 billion from 2022 to 2027; Europe to account for 53% of market growth - Technavio

Retrieved on: 
Tuesday, January 16, 2024

NEW YORK, Jan. 15, 2024 /PRNewswire/ -- The allergy immunotherapies market is expected to grow by USD 1.01 billion from 2022 to 2027.

Key Points: 
  • NEW YORK, Jan. 15, 2024 /PRNewswire/ -- The allergy immunotherapies market is expected to grow by USD 1.01 billion from 2022 to 2027.
  • The rapid development of allergy immunotherapies in the region is due to an increasing need for treating these allergic diseases.
  • Detailed information on factors that will drive the growth of the allergy immunotherapies market between 2022 and 2027.
  • Growth of the allergy immunotherapies market across North America, Europe, Asia, and ROW
    Comprehensive analysis of factors that will challenge the growth of allergy immunotherapies market companies.

Harrow Announces Availability of VEVYE® (Cyclosporine Ophthalmic Solution) 0.1%, the First and Only Cyclosporine-Based Product Indicated for Treating Both Signs and Symptoms of Dry Eye Disease

Retrieved on: 
Thursday, January 11, 2024

VEVYE, uniquely dispensed in a 10 microliter drop, is the first and only cyclosporine‑based product indicated for treating both the signs and symptoms of dry eye disease (DED).

Key Points: 
  • VEVYE, uniquely dispensed in a 10 microliter drop, is the first and only cyclosporine‑based product indicated for treating both the signs and symptoms of dry eye disease (DED).
  • In commenting on the announcement, Mark L. Baum, Chairman and Chief Executive Officer of Harrow, said, “We are thrilled to announce the availability of VEVYE for our customers and their patients.
  • VEVYE is powered by the unique combination of the reliable and trusted active ingredient, cyclosporine, and a water-free semifluorinated alkane delivery vehicle, perfluorobutylpentane.
  • In addition, 92% of this patient population remains un- or under-treated due to limited efficacy and poor tolerability of existing prescription and non-prescription choices.4