S15

NextCure Publishes Non-Clinical Data Demonstrating Anti-Siglec-15 Treatment Prevented Bone Loss Due to Immobilization from Acute Spinal Cord Injury

Retrieved on: 
Thursday, December 21, 2023
Veteran, Osteocalcin, Skeleton, Risk, Osteoporosis, Immobilization, Fracture, Messenger, Tibia, Tetraplegia, BSP, Society, Osteoblast, Cancer, Femur, Blood, S15, Manuscript, Patient, Therapy, Osteoclast, BMD, Medical imaging

The data demonstrated that NC605, a novel anti-Siglec-15 (S15) antibody, prevented bone loss, but more importantly preserved bone strength in animal models of severe immobilization resulting from acute spinal cord injury.

Key Points: 
  • The data demonstrated that NC605, a novel anti-Siglec-15 (S15) antibody, prevented bone loss, but more importantly preserved bone strength in animal models of severe immobilization resulting from acute spinal cord injury.
  • Following spinal cord injury, patients typically suffer rapid and extensive bone loss.
  • While anti-resorptive therapies have shown some efficacy in inhibiting bone loss, these agents also inhibit bone formation.
  • Blood and bone structure analyses revealed that the anti-S15 antibody was able to greatly inhibit bone resorption while maintaining bone formation and quality.

Tineco's Unmissable Offers to Celebrate Christmas 2023

Retrieved on: 
Friday, December 15, 2023
Home Goods, Other Retail, Pets, Family, Consumer Electronics, Technology, Consumer, Retail, Eye, Dust, Recycling, Running, Multimedia, LED, Fresh water, HEPA, Ultra, PURE, Rotation, Atmosphere, Water, Vacuum, Christmas, S15, Smart sensor, Suction, Dry cleaning, Ecovacs Robotics

To celebrate the Christmas holidays, Tineco has reserved special offers for its users, who will be able to purchase selected products at competitive prices.

Key Points: 
  • To celebrate the Christmas holidays, Tineco has reserved special offers for its users, who will be able to purchase selected products at competitive prices.
  • The offers are active until December 24th, just in time for last minute Christmas gifts!
  • In fact, the iLoop™ ring on the colored LED display changes from red to blue when the floor is clean.
  • While, thanks to the iLoop™ Smart Sensor, the appliance offers precise suction power that automatically adapts to the dirt detected, improving cleaning efficiency.

Preclinical Data Demonstrate Anti-Siglec-15 Treatment Reduced Bone Loss and Enhanced Bone Quality in Mice with Moderate-to-Severe Osteogenesis Imperfecta (OI)

Retrieved on: 
Tuesday, October 17, 2023
Hospital for Special Surgery, Male, Cortex, Spectroscopy, Female, BMD, Bone, Bone disease, Osteogenesis imperfecta, Society, Mab, Hospital, American Society for Bone and Mineral Research, Osteoporosis, Cancer, Fracture, Osteoclast, Calvarial doughnut lesions-bone fragility syndrome, Mouse, S15, Porosity, Life, OI, Patient, Medical imaging, Birth control

These results support development of NC605 as a potential highly effective treatment for osteogenesis imperfecta, a rare disease in which bones easily fracture.

Key Points: 
  • These results support development of NC605 as a potential highly effective treatment for osteogenesis imperfecta, a rare disease in which bones easily fracture.
  • Osteogenesis imperfecta is a rare disorder that results in high bone turnover, abnormal bone formation, bone fragility and recurrent fractures.
  • There is no cure for OI and current anti-resorptive treatments increase bone mineral density (BMD) primarily by inhibiting bone loss; however, these agents also inhibit bone formation.
  • Unlike anti-resorptive therapies, NC605 enhances osteoblast recruitment, resulting in overall enhanced bone quality.

Tineco's Fall Prime Day

Retrieved on: 
Monday, October 9, 2023
Home Goods, Online Retail, Retail, Consumer Electronics, Technology, Floor, Hair, Atmosphere of Earth, Multimedia, Dust, Acasă, Suction, PURE, AIR, Three Pure Ones, S15, Crumb, Max, Vacuum, Atmosphere, Poultry farming, Dry cleaning, Airline, Heating, ventilation, and air conditioning, Amazon, Ecovacs Robotics

In view of Amazon's highly anticipated Fall Prime Day, on 10 and 11 October Tineco returns with unmissable offers on various devices from the Floor One, Pure One and Carpet One lines.

Key Points: 
  • In view of Amazon's highly anticipated Fall Prime Day, on 10 and 11 October Tineco returns with unmissable offers on various devices from the Floor One, Pure One and Carpet One lines.
  • View the full release here: https://www.businesswire.com/news/home/20231009807594/en/
    Tineco Fall Prime Day Sale (Photo: Business Wire)
    FLOOR ONE S5 and FLOOR ONE S5 Pro 2: for thorough cleaning
    These are two models of floor cleaners which, thanks to their three main features (the running water cleaning system, sanitization-proof self-cleaning and drying and the iLoop Smart Sensor technology) are able to meet any need.
  • The FLOOR ONE S5 is available on Amazon on October 10 and 11 at a price of €389 (original price: €519).
  • The Carpet One is available on October 10 and 11 at a price of €319 (starting price: €519) on Amazon .

Durabook’s Next-Generation S15 Semi-Rugged Laptop with 12th Gen Intel® CPU Packs Performance into the Thinnest, Lightest, 15.6” Semi-Rugged Laptop in its Class

Retrieved on: 
Wednesday, September 20, 2023
Consumer Electronics, Technology, Manufacturing, Other Technology, Software, Other Manufacturing, Hardware, NVM Express, HD, S15, GPS, RAID, SIM, Thunderbolt (interface), CAD, USB, Multimedia, Payment card, RJ45, SSD, SATA, Organization, CPU, Pogo, Windows 11, Solid-state drive, Satellite navigation device, Video game, Conveyor system, Mobile phone

Durabook , an innovator in purpose-built, rugged computing solutions, today announced the launch of the next-generation S15 Semi-Rugged Laptop equipped with the latest Intel® 12th Gen Alder Lake platform.

Key Points: 
  • Durabook , an innovator in purpose-built, rugged computing solutions, today announced the launch of the next-generation S15 Semi-Rugged Laptop equipped with the latest Intel® 12th Gen Alder Lake platform.
  • “Durabook undertook this powerful set of upgrades to its S15 Semi-Rugged Laptop to empower field professionals with high performance and strong functionality that its ruggedness belies.”
    The Durabook S15 Semi-Rugged Laptop, At a Glance
    Significant CPU upgrade to latest Intel® 12th generation Alder Lake platform.
  • Delivered with Intel® Iris® Xe Graphics, boosting graphics power to process large amounts of data, images, and video feeds in real-time.
  • Optional dedicated NVIDIA® Quadro T1000 transforms the S15 Semi-Rugged Laptop into an ultimate solution for specific tasks such as graphics rendering, architectural illustrations, and CAD applications.

A Phase 2 Study of Anti-Siglec-15 Antibody, NC318, in Combination with Pembrolizumab (NCT04699123) Demonstrates Clinical Activity in Patients with Advanced PD-1 Axis Inhibitor Refractory NSCLC

Retrieved on: 
Tuesday, September 12, 2023
Research Excellence Framework, Yale Cancer Center, Yale University, S15, Myelocyte, Yale School of Medicine, Special Program of Assisted Reproduction, Cancer research, Clinical trial, RECIST, Cancer, Trae tha Truth, SITC, Pneumonitis, DRS, Oncology, Research, Lung cancer, Rash, Psoriasis, HIV disease progression rates, Patient, Immunoglobulin G, Translational research, Pericarditis, Mab, Ensign, Transverse myelitis, PD-1, Pembrolizumab, United Technologies, Tumor microenvironment, Safety, Vaccine, Pharmaceutical industry, Medical imaging, Medicine, Dermatology, NSCLC, Pharmacology

BELTSVILLE, Md., Sept. 12, 2023 (GLOBE NEWSWIRE) -- NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases, today announced the presentation of Phase 2 clinical data by collaborators at the Yale Cancer Center demonstrating clinical benefit in patients with advanced, PD-1 axis inhibitor refractory non-small cell lung cancer (NSCLC) treated with a combination regimen of NC318, a Siglec-15 (S15) monoclonal antibody (mAb), and pembrolizumab, an anti-PD-1 antibody.

Key Points: 
  • In an earlier monotherapy study from NextCure, NC318 demonstrated single agent activity in a Phase 1/2 dose escalation trial (NCT03665285) for patients with advanced solid tumors (Tolcher et al, SITC 2019).
  • The ongoing NCT04699123 study is a randomized trial designed to assess the safety and efficacy of NC318 alone or in combination with pembrolizumab.
  • The combination portion of the study is assessing efficacy in NSCLC subjects who have experienced disease progression on, or after, PD-1 axis inhibitor therapy.
  • NC318 infusion reactions were seen in seven patients (three Grade 3, four Grade 2), six receiving the combination and one NC318 alone.

Preclinical Data Demonstrate Potential Application of Anti-Siglec-15 Treatment in Bone Disease

Retrieved on: 
Tuesday, September 5, 2023
Osteoporosis, Therapy, Blood, Osteocalcin, Tibia, Cancer, Quality of life, Mount Sinai, BMD, Bone disease, Immobilization, Multiple sclerosis, Messenger, Military personnel, Osteoblast, BSP, Patient, Icahn School of Medicine at Mount Sinai, Femur, Osteoclast, SCI, Vaccine, Medical imaging, S15, Veteran, Medicine

While anti-resorptive therapies have shown some efficacy in inhibiting bone loss, these agents also inhibit bone formation.

Key Points: 
  • While anti-resorptive therapies have shown some efficacy in inhibiting bone loss, these agents also inhibit bone formation.
  • In preclinical testing, NC605 has been shown to prevent bone loss by inhibiting osteoclast maturation and bone resorption by binding S15, which is expressed on the cell surface of immature osteoclasts and upregulated in differentiated osteoclasts.
  • Blood and bone structure analyses revealed that the anti-S15 antibody was able to greatly inhibit bone resorption while maintaining bone quality.
  • Title: Development of a Novel Therapeutic, anti-Siglec-15 Antibody, to Reduce Bone Loss and Enhance Bone Integrity after Acute Spinal Cord Injury-induced Immobilization

Summer, Sun, Discounts - Smart Vacuum Cleaner Prices From Tineco

Retrieved on: 
Tuesday, August 15, 2023
Retail, Consumer Electronics, Discount, Variety, Technology, Home Goods, Hardware, S15, Hair, Suction, Atmosphere, Rotation, Multimedia, LCD, Sale, Atmosphere of Earth, AIR, Fresh water, Water, Dust, Bacteria, PURE, Conveyor system, Ecovacs Robotics, Amazon

Tineco, a leading pioneer in the field of floor care and smart home appliances, today announces tempting summer discounts.

Key Points: 
  • Tineco, a leading pioneer in the field of floor care and smart home appliances, today announces tempting summer discounts.
  • Although the higher temperatures are unfortunately still a long time coming, Tineco will lure you from August 14th to 27th with summer discounts for the smart vacuum cleaners FLOOR ONE S7 PRO, PURE ONE AIR PRO and PURE ONE S15 PRO.
  • These special discounts will be available on the Tineco website and on Amazon during this period.
  • The vacuum cleaner not only impresses with its timeless design, but also with its ergonomic handling.

Tineco is reducing prices on the occasion of Amazon Prime Day

Retrieved on: 
Tuesday, July 11, 2023
Online Retail, Home Goods, Retail, S15, Hair, Suction, Electronics, Multimedia, Amazon, Fresh water, Water, Power, SMART, PURE, Janitor, Electric motor, Dry cleaning, Ecovacs Robotics

Tineco , a leading pioneer in the field of floor care and smart home appliances, today announced that it will be offering selected products at heavily discounted prices on Amazon Prime Day on July 11 and 12.

Key Points: 
  • Tineco , a leading pioneer in the field of floor care and smart home appliances, today announced that it will be offering selected products at heavily discounted prices on Amazon Prime Day on July 11 and 12.
  • The offer includes the Tineco PURE ONE S15 PRO and Tineco PURE ONE S15 ESSENTIALS cordless vacuum cleaners as well as the Tineco FLOOR ONE S3 , Tineco FLOOR ONE S5 and Tineco FLOOR ONE S5 Combo Power KIT vacuum cleaners.
  • In addition, the Tineco CARPET ONE carpet cleaner is also being offered at a greatly reduced price.
  • Founded in 1998, Tineco is dedicated to developing quality home electronics that are helpful, easy to use and intelligent.

Tineco's Proposals for Celebrating Love During the Wedding Season

Retrieved on: 
Friday, June 16, 2023
Online Retail, Home Goods, Retail, S15, Hair, Tangle, Three Pure Ones, Life, Atmosphere, Crumb, Multimedia, Ecovacs Robotics, Love, Water, Dust, Spouse, PURE, Nightclub, Amazon

The month of June marks the beginning of summer and, for many couples in love and ready to take the big step, also the beginning of the wedding season.

Key Points: 
  • The month of June marks the beginning of summer and, for many couples in love and ready to take the big step, also the beginning of the wedding season.
  • The future spouses thus enter a whirlwind of commitments, untangling plans to make and to-do lists to write, and among these, the wedding registry cannot be missing.
  • View the full release here: https://www.businesswire.com/news/home/20230615442671/en/
    What to include in the wedding registry?
  • Designed for the couple who shares their love with a four-legged friend, Tineco has created the Pure One S15 Pet model.