Ketoconazole

• The ISN World Congress of Nephrology will be held in Buenos Aires, Argentina April 13-16, 2024.
• Presentations will highlight the eGFR results found in patients on Nefecon as well as the data on quality of life during the trial.
• There will also be a presentation on the subanalysis evaluating benefits of Nefecon for patients with lower levels of UPCR.
• The congress will include a symposium, Evolving Landscape of eFGR and Proteinuria Surrogate Markers in IgA Nephropathy, moderated by KOL Richard Lafayette, M.D., F.A.C.P.

Human medicines European public assessment report (EPAR): Toviaz, fesoterodine, Date of authorisation: 20/04/2007, Revision: 28, Status: Authorised

• STOCKHOLM, Oct. 19, 2023 /PRNewswire/ -- Calliditas Therapeutics AB (NASDAQ: CALT) (NASDAQ Stockholm: CALTX) ("Calliditas"), today announced seven abstract presentations, including a late-breaking poster presentation, highlighting additional analyses of the Phase 3 NefIgArd study at the upcoming American Society of Nephrology (ASN) Kidney Week 2023 in Philadelphia, PA, November 1-5, 2023.
• Poster presentation details are below and will be available on the Presentation and Publication page on the Calliditas' corporate website following the meeting.
• It has not been established whether TARPEYO slows kidney function decline in patients with IgAN.
• Continued approval for this indication may be contingent upon verification and description of clinical benefits in a confirmatory clinical trial.

• Up to half of all adults have had this scalp condition at one point, so you’ll no doubt know about these skin flakes and the itchiness.
• It can affect many aspects of people’s lives, such as how they socialise, how they style their hair, and what clothes they wear.
• We don’t know for sure whether our ancestors were as bothered by it as much as we are today.

What causes dandruff?

• The yeast feeds on sebum, the natural moisturiser secreted by your sebaceous glands to stop your skin drying out.
• These glands are attached to every hair follicle and the hair provides a dark, sheltered micro-environment ideal for the yeast to flourish.
• This causes the cells to cluster together, appearing as white flakes.

Why do I have dandruff?

• This depends on a range of factors.
• Other factors include your immunity, and external factors, such as which hair-care products you use.

How do I get rid of dandruff?

• The shampoos most commonly contain the anti-fungal agent zinc pyrithione (ZnPT for short).
• Other common anti-fungals in shampoos include selenium sulfide, ketoconazole and coal tar.
• You can also treat dandruff with scalp masks and scrubs that help restore the scalp barrier, by reducing inflammation and irritation.

Why does my dandruff come back?

• Our research focussing on zinc pyrithione-based products showed these shampoos reached the skin surface.
• We found the zinc pythione seemed to target the top of the follicles rather than deep into the follicles.
• Your shampoo’s active ingredient may not reach the yeast that causes your dandruff.

What about future treatments?

• These might target how the yeast grows in a different way to current active ingredients.
• These include pre-biotics (supplements or food for skin flora) or pro-biotics (products that contain skin flora).

In a nutshell

• Hopefully, we can develop improved shampoos that better deliver the active ingredient to where it’s needed.
• These are important for our immunity, including preventing more disease-causing microbes (pathogens) from moving in.
• They also help the skin produce antimicrobial peptides (short proteins) that protect us from pathogens.