Smouldering

The International Myeloma Foundation and Black Swan Research Initiative® Announce the Release of New iStopMM Cohort Study: A Multivariable Prediction Model for Bone Marrow Sampling on Individuals with MGUS

Retrieved on: 
Thursday, April 11, 2024

IMF Chief Scientific Officer and co-author of the iStopMM cohort study Dr. Brian G.M.

Key Points: 
  • IMF Chief Scientific Officer and co-author of the iStopMM cohort study Dr. Brian G.M.
  • Groups 2 and 3 were evaluated at the study clinic for initial assessment and follow-up, including bone marrow sampling,” according to the study.
  • However, [this] model requires validation in other populations.”
    To know the full details of the iStopMM cohort study , view it online.
  • This research was funded by the International Myeloma Foundation and the European Research Council.

AB Science receives notice of allowance for European patent covering masitinib until 2036 in the treatment of mastocytosis

Retrieved on: 
Monday, January 15, 2024

AB Science SA (Euronext - FR0010557264 - AB) today announced that the European Patent Office has issued a Notice of Allowance for a patent relating to methods of treating severe systemic mastocytosis (i.e.

Key Points: 
  • AB Science SA (Euronext - FR0010557264 - AB) today announced that the European Patent Office has issued a Notice of Allowance for a patent relating to methods of treating severe systemic mastocytosis (i.e.
  • This new European patent provides intellectual property protection for masitinib in this indication until October 2036.
  • Masitinib is positioned as a treatment of severely symptomatic systemic mastocytosis patients, including the subvariants of indolent and smoldering systemic mastocytosis, who are unresponsive to optimal symptomatic treatment.
  • The Notice of Allowance (NOA) means that the European Patent Office intends to grant the patent application, EP3359195A1, after the completion of certain formal procedural steps.

Maui's deadly wildfires burn through Lahaina – it's a reminder of the growing risk to communities that once seemed safe

Retrieved on: 
Thursday, August 10, 2023

Others were rescued by the U.S. Coast Guard after going into the ocean to escape the flames.

Key Points: 
  • Others were rescued by the U.S. Coast Guard after going into the ocean to escape the flames.
  • Fires were still burning on Aug. 10, both in Maui’s tourist-filled west coast and farther inland, as well as on the Big Island of Hawaii.
  • Dry grasses and strong winds, influenced by Hurricane Dora passing far to the south, heightened the fire risk.
  • That number – people directly exposed to wildfires – more than doubled from 2000 to 2019, my team’s recent research shows.
  • Instead, three-quarters of this trend was driven by intense fires growing out of control and encroaching on existing communities.

What climate change has to do with wildfires

    • Recent research on California’s fires found that almost all of the increase in that state’s burned area in recent decades was due to anthropogenic climate change – meaning climate change caused by human activities.
    • Our new research looked beyond just the area burned and asked: Where were people exposed to wildfires, and why?

Where wildfire exposure was highest

    • If you picture wildfire photos taken from a plane, fires generally burn in patches rather than as a wall of flame.
    • Three-quarters of the 125% increase in exposure was due to fires increasingly encroaching on existing communities.
    • In California, the state with the most people exposed to fires, several wildfire catastrophes hit communities that had existed long before 2000.

What communities can do to lower the risk

    • How much these fires grow and how intense they become depends largely on warming trends.
    • But communities will also have to adapt to more wildfires.
    • Developing community-level wildfire response plans, reducing human ignitions of wildfires and improving zoning and building codes can help prevent fires from becoming destructive.

TELUS Pollinator Fund invests in Dryad Networks, helping to combat the devastating effects of wildfires

Retrieved on: 
Thursday, July 27, 2023

“TELUS recognizes that there is an urgent need to scale innovative wildfire detection technologies and that’s why the Pollinator Fund is investing in Dryad,” said Blair Miller, Managing Partner, TELUS Pollinator Fund. “More than 10 million hectares -- an area about three times the size of Belgium -- have already burned this year in Canada alone, and the annual national cost of fire protection exceeded $1 billion for six of the last 10 years. Not only can Dryad sensors limit economic losses, but they also have a significant impact in the fight against climate change. They protect vital ecosystems and can even save human lives by alerting first responders within minutes of a wildfire starting.”

Key Points: 
  • “TELUS recognizes that there is an urgent need to scale innovative wildfire detection technologies and that’s why the Pollinator Fund is investing in Dryad,” said Blair Miller, Managing Partner, TELUS Pollinator Fund.
  • Not only can Dryad sensors limit economic losses, but they also have a significant impact in the fight against climate change.
  • “We are delighted to receive the investment from the TELUS Pollinator Fund for Good,” said Carsten Brinkschulte, Co-founder and CEO at Dryad Networks.
  • Together with TELUS, we are committed to addressing the critical issue of wildfires and building more resilient communities.”

'Zombie fires' in the Arctic: Canada's extreme wildfire season offers a glimpse of new risks in a warmer, drier future

Retrieved on: 
Tuesday, July 18, 2023

Apocalyptic orange skies and air pollution levels that force people indoors only tell part of the story, though.

Key Points: 
  • Apocalyptic orange skies and air pollution levels that force people indoors only tell part of the story, though.
  • As global temperatures rise, fires are also spreading farther north and into the Arctic.
  • These underground fires are known as “zombie fires,” and there are a number of reasons to worry about the trend.
  • Recent research finds that Arctic soil fires can smolder through the winter and reignite during early spring when temperatures rise, hence the nickname “zombie fires.”

The Arctic is increasingly flammable

    • However, the severity, frequency and types of wildfires in northern and Arctic regions have changed in recent decades.
    • One major culprit is the rising temperature: The Arctic is warming nearly four times faster than the rest of the world, a phenomenon known as Arctic amplification.
    • As the Arctic warms and fires move farther northward, peat soils rich in dead plant material burn at an accelerated rate.
    • Northern ecosystems store twice as much carbon in their peat and permafrost as the atmosphere, and both are increasingly vulnerable to fire.

What is a zombie fire?

    • Ground fires, on the other hand, do not flame but burn more slowly and have the tendency to spread deep into the ground and spread laterally.
    • During the 2019-2020 fire season in Siberia, zombie fires were blamed for rekindling fires the following year.
    • They were ignited by slash-and-burn activities to plant palm plantations and amplified by drought conditions during a severe El Niño event.

Some hope and caution from past lessons

    • My work and that of many colleagues, however, focus on the combustion of above-ground biomass.
    • In the meantime, the continuing waves of wildfire haze in Canada and the U.S. are a reminder of the impact of these fires.
    • Best practices for safely fighting zombie fires are also needed, along with better public education about the health risks of wildfire smoke.

Institute for Crisis Management Releases 2022 Annual Crisis Report

Retrieved on: 
Monday, July 17, 2023

SOUTH BEND, Ind., July 17, 2023 /PRNewswire/ -- In a post-pandemic rebound, smoldering crisis stories again were a majority of the news items tallied in 2022, according to the Institute for Crisis Management® (ICM). "We started seeing certain categories returning to typical pre-pandemic ranges, but as always, there were a few surprises in the data," said Deborah Hileman, SCMP, ICM president and CEO. In 2022, ICM tracked 2,150,826 crisis news items, a decrease of five percent over 2021.

Key Points: 
  • The 32nd annual report examines the year's crisis news and identifies emerging trends of concern to business leaders.
  • SOUTH BEND, Ind., July 17, 2023 /PRNewswire/ -- In a post-pandemic rebound, smoldering crisis stories again were a majority of the news items tallied in 2022, according to the Institute for Crisis Management® (ICM).
  • In 2022, ICM tracked 2,150,826 crisis news items, a decrease of five percent over 2021.
  • The 2022 ICM Annual Crisis Report is a compilation of news, trends and highlights of business crises, giving leaders valuable insight into the impact crises have on the organization and its stakeholders.

'Zombie fires' are occurring more frequently in boreal forests, but their impacts remain uncertain

Retrieved on: 
Wednesday, July 12, 2023

This article is part of La Conversation Canada’s series The boreal forest: A thousand secrets, a thousand dangers La Conversation Canada invites you to take a virtual walk in the heart of the boreal forest.

Key Points: 
  • This article is part of La Conversation Canada’s series The boreal forest: A thousand secrets, a thousand dangers La Conversation Canada invites you to take a virtual walk in the heart of the boreal forest.
  • It also avoids stoking the pervasive negative perceptions regarding wildfire, which in the boreal is an essential agent of forest renewal and health.
  • As a team of scientists who have dedicated our careers to understanding changing boreal fire regimes, we decided to find out for ourselves.

Unusual fire behaviour

    • Fire behaviour refers to the way a fire burns.
    • This seemingly unusual fire behaviour was previously of limited concern as overwintering fires are hard to detect and, we think, were relatively infrequent.

Remote fire study

    • Last summer, our team visited sites in the southern Northwest Territories that had ignited in 2014, experienced overwintering fire, and reignited in 2015.
    • These were paired with neighbouring sites from the same 2014 fire that had experienced only a single season fire.
    • All potential sites were incredibly remote and could only be accessed by helicopter — our team was able to use one that was on standby for fire duty as it was a relatively quiet fire season.

Carbon emissions

    • The most socially relevant concern relates to carbon emissions and potential feedbacks to climate warming.
    • Boreal peatlands are thought to store as much as 30 per cent of the Earth’s terrestrial carbon stocks.
    • As such, threats to these regions have the potential to compound already rapid increases in atmospheric carbon dioxide concentrations that underlie global warming.

Failure to renew

    • We expect that zombie fires will lead more commonly to regeneration failure — conversion of forest to non-forest — for three main reasons.
    • Changes in forest type or failure for forests to recover affects wildlife habitat availability among other impacts, an issue of increasing concern, particularly in the context of declining caribou populations across North America.

Remote sensing advances

    • However, advances in space-borne remote sensing have allowed the detection of early spring reignitions, which when combined with information on fire perimeters from the previous year, support accurate detection and mapping of overwintering fires that reignite.
    • It will also lead to important insights into carbon losses from this fascinating — although poorly understood — fire behaviour.
    • These research grants and contracts support fundamental research on the response of northern high latitude ecosystems to permafrost thaw and wildfire.

TALISKER DISTILLERY UNVEILS THE LATEST RELEASE OF ITS 30 YEAR OLD SINGLE MALT SCOTCH WHISKY

Retrieved on: 
Thursday, June 29, 2023

NEW YORK, June 29, 2023 /PRNewswire/ -- The Talisker distillery has announced the highly anticipated annual return of Talisker 30 Year Old with its award-winning 2023 limited edition release. Talisker 30 Year Old is a whisky made by the sea that embodies the rugged shores of the Isle of Skye in Scotland. For nearly 200 years, the distillery has crafted Single Malt Scotch Whisky on the coast alongside the infamous Oyster Shed, where whisky has been paired with fresh, local oysters for decades. Honoring its distillery home and legacy of seafood pairings, Talisker 30 Year Old was created to pay tribute to the Isle's natural wonders.

Key Points: 
  • Talisker 30 Year Old is a whisky made by the sea that embodies the rugged shores of the Isle of Skye in Scotland.
  • For nearly 200 years, the distillery has crafted Single Malt Scotch Whisky on the coast alongside the infamous Oyster Shed, where whisky has been paired with fresh, local oysters for decades.
  • Honoring its distillery home and legacy of seafood pairings, Talisker 30 Year Old was created to pay tribute to the Isle's natural wonders.
  • Talisker 30 Year Old is an elegant and complex whisky with the distillery's hallmarks of soaring sweet smoke and pointy pepperiness.

Research Reveals Novel Insights into Transplant Rejection and New Drug Development Targets

Retrieved on: 
Wednesday, June 28, 2023

CINCINNATI, June 28, 2023 /PRNewswire/ -- Imagine a day when a urine test could inform a doctor precisely why a kidney transplant patient was experiencing organ rejection and suggest the best medication for specifically addressing the problem.  

Key Points: 
  • Findings suggests that multiple organ rejection events may actually be one, longer, smoldering rejection event.
  • "Having a precision-medicine approach to treating organ rejection has the potential to markedly reduce the threat rejection poses to transplanted organs," Woodle says.
  • However, once a kidney transplant recipient experiences acute rejection, many go on to lose their transplant and return to dialysis within 1-3 years.
  • "Thanks to insights like these, we may be able to substantially reduce loss of transplanted organs to rejection, thereby freeing up donated organs for new transplant recipients."

Blueprint Medicines Submits Supplemental New Drug Application to FDA for AYVAKIT® (avapritinib) for the Treatment of Indolent Systemic Mastocytosis

Retrieved on: 
Wednesday, November 23, 2022

CAMBRIDGE, Mass., Nov. 22, 2022 /PRNewswire/ -- Blueprint Medicines Corporation (NASDAQ: BPMC) today announced the submission of a supplemental new drug application to the U.S. Food and Drug Administration (FDA) for AYVAKIT® (avapritinib) for the treatment of adults with indolent systemic mastocytosis (SM). AYVAKIT was designed to potently and selectively inhibit D816V mutant KIT, the underlying cause of SM in about 95 percent of cases.

Key Points: 
  • CAMBRIDGE, Mass., Nov. 22, 2022 /PRNewswire/ --Blueprint Medicines Corporation(NASDAQ:BPMC) today announced the submission of a supplemental new drug application to theU.S.
  • Food and Drug Administration(FDA) for AYVAKIT (avapritinib) for the treatment of adults with indolent systemic mastocytosis (SM).
  • The FDA has granted breakthrough therapy designation to AYVAKIT for the treatment of moderate to severe indolent SM.
  • Blueprint Medicines, AYVAKIT, AYVAKYTand associated logos are trademarks ofBlueprint Medicines Corporation.