Midazolam

• Melt Pharmaceuticals, Inc. (“Melt”), a clinical‑stage pharmaceutical company developing novel approaches for procedural sedation, today announced the completion of its Series B Preferred Stock financing of approximately $24 million from new and existing investors at a pre‑money valuation that increased nearly 150% from the pre-money valuation for Melt’s Series A Preferred Stock financing in 2019.
• The capital raised will primarily support the further development of MELT-300, including the MELT-300 Phase 3 program.
• “With this round of financing, we’ve obtained the funding to further the development of MELT-300, including conducting our recently commenced Phase 3 program.
• Their shared belief in the vision of MELT-300 and their confidence in its potential to revolutionize short-duration procedural sedation is incredibly valuable to us.”
  Newbridge Securities Corporation acted as the exclusive placement agent for the Series B Preferred Stock Offering.

• But experiencing a seizure does not always mean a person has epilepsy.
• Seizures can be provoked by acute head injuries, alcohol withdrawal and high blood sugar, among other things.

What does a seizure look like?

• For some people, their seizure is a purely internal sensation.
• In fact, most people with epilepsy have only relatively subtle, nonconvulsive seizures at first, then develop convulsive seizures over time.
• This is the type of seizure most of us are familiar with, probably because it’s the kind most frequently depicted, though not always accurately, in movies and on television.
• The most common type of epileptic seizure are those that are focal – that is, they arise from a confined region of the brain.

What causes a seizure to occur?

Seizures are the result of abnormal electrical activity in the brain. The bursts of activity disrupt normal functioning and initiate hyperactivity in the affected brain area, which then can affect the corresponding body part. For instance, if the seizure arises from the part of the brain involved in arm movement, that arm will experience involuntary hyperactivity.

If you’re a bystander, how can you help?

• Many seizure-related injuries occur due to falling or coming in contact with sharp or hard objects.
• If they begin to fall, help them to the floor as gently as possible and put something soft under their head.
• During the convulsive phase of a seizure, breathing may be intermittent.
• So turn the person on their side so they can breathe more easily and lower the risk of aspiration.
• Following the seizure, and as the person gradually recovers and wakes up, help them sit up in a safe space.

Are new treatments available?

• People with epilepsy, particularly those who experience frequent seizures, will often have emergency medications in their possession.
• The most common emergency medications – also called seizure rescue medications – are a type of anticonvulsants called benzodiazepines.
• Patients and their caretakers may have access to rescue medications and know how to use them.

What if it’s not a seizure?

If a bystander does not witness a seizure, but instead finds someone unresponsive or minimally responsive, call 911. They may be suffering from other medical issues, such as a drug overdose. And if you are interested in training and certification for seizure first aid, or if you simply want to know more, the Epilepsy Foundation has more information.

• Jacob Pellinen has received research support from the Department of Neurology at the University of Colorado School of Medicine, the Colorado Clinical and Translational Sciences Institute, NIH/NINDS, and the American Epilepsy Society.
• J. Pellinen serves as chair of the professional advisory board for the Epilepsy Foundation of Colorado and Wyoming (unpaid), serves as the Epilepsy Section Editor for Current Neurology and Neuroscience Reports, and has received compensation for serving on the scientific advisory board for SK Life Science.

• Surabaya, East Java, Indonesia, Oct 30, 2023 - (ACN Newswire) - A medical professor at Airlangga University, Prastiya Indra Gunawan, has developed a new epilepsy treatment method that involves administering midazolam intramuscularly and intranasally.
• Airlangga University professor Prastiya Indra Gunawan has devised a new treatment method that involves providing midazolam intramuscularly and intranasally to epilepsy patients.
• This is different from rectal diazepam, which takes 180 seconds," Professor Gunawan, a pediatrician from Airlangga University, said.
• With the establishment of the epilepsy center, Gunawan said he hopes that people with epilepsy will not only receive healthcare, but also see improvements in their social life.

• The full presentation may be viewed on the Company's web page Link .
• The Company further invites interested parties to subscribe to their email alert service stay up to date on company's progress here: NRX Email Alerts .
• The findings of this trial confirm the results reported by Grunebaum and coworkers (Am J Psychiatry 2018;175:327 Link ) and numerous smaller trials.
• Preliminary estimates of this regulatory focused work show that this effort is within the company's current budget.