Overdiagnosis

What if flat feet were…normal? Debunking a myth about injuries

Retrieved on: 
Tuesday, April 23, 2024

Specifically, having flat feet was believed to predispose individuals to future pain and other musculoskeletal problems (i.e.

Key Points: 
  • Specifically, having flat feet was believed to predispose individuals to future pain and other musculoskeletal problems (i.e.
  • Flat feet were believed to be a kind of time bomb.
  • We demonstrate that the theory that having flat feet inevitably leads to pain or other musculoskeletal problems, is unfounded.

Where does this theory come from?

  • This theory became central to the educational programs of health professionals.
  • In fact, science has never validated the theory: it has remained at the hypothesis stage.
  • Nevertheless, over the years up until the present, many health professionals have continued to support the theory that flat feet pose a major risk for developing musculoskeletal disorders.

Do flat feet cause musculoskeletal injuries?

  • Furthermore, a systematic review and a meta-analysis concluded that runners with flat feet are no more at risk of injury than those with regular feet.
  • These analyses call into question the idea that people with flat feet have a substantial risk of developing musculoskeletal disorders.
  • Unfortunately, this frequently results in people having unnecessary interventions, such as using orthopaedic shoes or custom-made foot orthoses for asymptomatic flat feet.

Setting the record straight

  • Based on current scientific knowledge, assessing whether a person has flat feet to determine their risk of injury is ineffective and counterproductive.
  • While it is possible for a person with flat feet to develop a musculoskeletal injury, this does not necessarily mean that flat feet caused the injury.
  • It is quite possible for two variables to be present at the same time without there being a causal link.
  • A cause-and-effect relationship implies that a change in one variable (the cause) leads to a change in another variable (the effect).

Reducing overdiagnosis in health care

  • Reducing overdiagnosis in health care has become crucial.
  • Since overdiagnosis often leads to overtreatment, avoiding unnecessary treatments will help to alleviate patients’ concerns about their flat feet.
  • It’s time to change our perspective and our approach to the significance of flat feet and to recognize their natural diversity in the context of overall foot health.


Gabriel Moisan is a member of the Ordre des Podiatres du Québec (College of Podiatrists Québec). He has received funding from the Natural Sciences and Engineering Research Council of Canada (NSERC), the War Amps of Canada and the Réseau provincial de recherche en adaptation-réadaptation (REPAR).

Ibex Presents New Data from Multiple Studies Showcasing Accuracy of AI in Prostate, Breast and Gastric Cancer Diagnosis

Retrieved on: 
Thursday, March 21, 2024

BOSTON, March 21, 2024 /PRNewswire/ -- Ibex Medical Analytics (Ibex), the leader in AI-powered cancer diagnostics, today announced excellent results across multiple clinical studies conducted with the University of Pittsburgh Medical Center (UPMC), Brigham and Women's Hospital, Champalimaud Foundation and Ohio State University (OSU). These studies, highlighting the value of Ibex's AI-powered cancer diagnostics solutions in both diagnostic quality and efficiency, will be presented next week at the United States and Canadian Academy of Pathology (USCAP) Annual Meeting.

Key Points: 
  • Brigham and Women's Hospital and Champalimaud Foundation research shows high accuracy levels of Galen Breast in identifying microinvasive carcinoma of the breast.
  • Ohio State University Wexner Medical Center studies show high accuracy for Galen Breast and Galen Gastric in detecting and distinguishing between different types of cancer and in identifying multiple important pathologies.
  • In addition, researchers from OSU Wexner Medical Center will present studies validating Galen Breast's performance in detecting different types of breast cancer.
  • Ibex will be showcasing these findings at the USCAP Annual Meeting taking place in Baltimore, Maryland, between March 23 to 28, at booth number 755.

Feminist narratives are being hijacked to market medical tests not backed by evidence

Retrieved on: 
Thursday, February 15, 2024

In the 1980s, companies co-opted messaging about female autonomy to encourage women’s consumption of unhealthy commodities, such as tobacco and alcohol.

Key Points: 
  • In the 1980s, companies co-opted messaging about female autonomy to encourage women’s consumption of unhealthy commodities, such as tobacco and alcohol.
  • Today, feminist narratives around empowerment and women’s rights are being co-opted to market interventions that are not backed by evidence across many areas of women’s health.
  • Some of these health technologies, tests and treatments are useful in certain situations and can be very beneficial to some women.

The AMH test

  • The AMH test is a blood test associated with the number of eggs in a woman’s ovaries and is sometimes referred to as the “egg timer” test.
  • Although often used in fertility treatment, the AMH test cannot reliably predict the likelihood of pregnancy, timing to pregnancy or specific age of menopause.
  • Despite this, several fertility clinics and online companies market the AMH test to women not even trying to get pregnant.
  • Some use feminist rhetoric promising empowerment, selling the test as a way to gain personalised insights into your fertility.
  • 'Egg timer' tests can't reliably predict your chance of conceiving or menopause timing

    Our recent study found around 30% of women having an AMH test in Australia may be having it for these reasons.

Breast density notification


Breast density is one of several independent risk factors for breast cancer. It’s also harder to see cancer on a mammogram image of breasts with high amounts of dense tissue than breasts with a greater proportion of fatty tissue. While estimates vary, approximately 25–50% of women in the breast screening population have dense breasts.

  • Stemming from valid concerns about the increased risk of cancer, advocacy efforts have used feminist language around women’s right to know such as “women need to know the truth” and “women can handle the truth” to argue for widespread breast density notification.
  • Yet, there is no or little mention of the lack of robust evidence showing that it prevents breast cancer deaths.
  • While stronger patient autonomy is vital, campaigning for breast density notification without stating the limitations or unclear evidence of benefit may go against the empowerment being sought.

Ensuring feminism isn’t hijacked

  • But we need to ensure the goals of feminist health advocacy aren’t undermined through commercially driven use of feminist language pushing care that isn’t based on evidence.
  • Health professionals and governments must also ensure that easily understood, balanced information based on high quality scientific evidence is available.


Brooke Nickel receives fellowship funding from the National Health and Medical Research Council (NHMRC). She is on the Scientific Committee of the Preventing Overdiagnosis Conference. Tessa Copp receives fellowship funding from the National Health and Medical Research Council (NHMRC). She is also on the Scientific Committee of the Preventing Overdiagnosis Conference.

Cleveland Diagnostics Completes $75M Financing to Advance its Early-detection Oncology Testing Platform

Retrieved on: 
Wednesday, January 17, 2024

Cleveland Diagnostics, Inc. , a clinical-stage biotechnology company developing next-generation diagnostic tests for the early detection of cancers announced the closing of over $75M in growth capital financing.

Key Points: 
  • Cleveland Diagnostics, Inc. , a clinical-stage biotechnology company developing next-generation diagnostic tests for the early detection of cancers announced the closing of over $75M in growth capital financing.
  • The financing will accelerate Cleveland Diagnostics’ commercial and corporate development goals.
  • Cleveland Diagnostics’ portfolio of oncology related tests will be expanding beyond prostate cancer into additional indications in 2024.
  • In connection with the financing, Jee will join the Cleveland Diagnostics Board of Directors.

Aditxt, Inc.’s Subsidiary Pearsanta, Inc. Acquires MDNA Life Sciences Inc.’s Proprietary Mitomic™ Testing Platform Pioneering Early Disease and Cancer Detection in a Transaction Valued at Approximately $25 Million

Retrieved on: 
Monday, January 8, 2024

This strategic move reinforces Pearsanta’s dedication to enhancing patient outcomes through early disease detection and the power of precision diagnostics.

Key Points: 
  • This strategic move reinforces Pearsanta’s dedication to enhancing patient outcomes through early disease detection and the power of precision diagnostics.
  • The platform includes a rich biomarker portfolio addressing a wide range of high-priority health concerns beyond oncology, extending into areas of substantial medical need.
  • Highlights from the asset portfolio include:
    The Mitomic Endometriosis Test (MET™) is in development as a blood-based assay for diagnosis of endometriosis.
  • The overarching goal is to enhance clinical outcomes by offering non-invasive or minimally invasive testing at the early stages of disease progression.

iCAD’s ProFound AI Can Predict 1-2 Year Risk for Breast Cancer and Reveal Insights for Heart Disease

Retrieved on: 
Monday, November 27, 2023

NASHUA, N.H., Nov. 27, 2023 (GLOBE NEWSWIRE) -- iCAD, Inc. (NASDAQ: ICAD), a global medical technology leader in innovative cancer-detection solutions, will present new studies validating its artificial intelligence (AI) powered ProFound Breast Health Suite for uncovering hidden heart or vascular disease and predicting a woman’s risk for developing breast cancer in the next one- or two-years. Researchers will present their findings at the Radiological Society of North America’s (RSNA) annual meeting in Chicago, Nov. 27 – 30, 2023.

Key Points: 
  • Blending artificial intelligence with computer-aided detection (AI CAD), the iCAD software platform, ProFound Breast Health Suite, can screen a single mammogram for two of the top causes of death for women: breast cancer and heart disease.
  • In fact, women with breast arterial calcifications, or BAC, are 51% more likely to develop heart disease.
  • He and his colleagues found the ProFound Heart Health AI algorithm highly accurate in uncovering BAC in mammograms.
  • ProFound Heart Health***: a new solution for measuring cardiovascular calcium deposits, alerting to possible vascular or heart disease (pending FDA clearance).

Cleveland Diagnostics Announces Prostate Cancer Awareness Month Campaign: ‘A PSA on PSA’

Retrieved on: 
Wednesday, August 30, 2023

Cleveland Diagnostics, Inc. , a leading commercial-stage biotechnology company, is launching its inaugural Prostate Cancer Awareness Campaign this September: ‘ A PSA on PSA.

Key Points: 
  • Cleveland Diagnostics, Inc. , a leading commercial-stage biotechnology company, is launching its inaugural Prostate Cancer Awareness Campaign this September: ‘ A PSA on PSA.
  • For every fact sheet download, Cleveland Diagnostics will make a donation to ZERO Prostate Cancer to fund research and other important support initiatives.
  • During the month of September, donations will be doubled by Golf Fights Cancer in celebration of the awareness month.
  • "By collaborating with Cleveland Diagnostics on the 'A PSA on PSA' campaign, we are empowering men to take charge of their prostate health.

Keeping up with advanced MRI: Kim Kardashian promotes whole-body scans. Could they be worth the hype?

Retrieved on: 
Wednesday, August 23, 2023

The worlds of pop culture and advanced imaging technology intersected recently when Kim Kardashian promoted a commercial whole-body magnetic resonance imaging (MRI) service on social media as a tool to detect cancer and aneurysms.

Key Points: 
  • The worlds of pop culture and advanced imaging technology intersected recently when Kim Kardashian promoted a commercial whole-body magnetic resonance imaging (MRI) service on social media as a tool to detect cancer and aneurysms.
  • The post attracted criticism from members of the medical community, who expressed concern about the lack of evidence for widespread use of this technology in people who are disease free.

Not new, but improved

    • MRI uses strong magnetic fields to coax a signal from water molecules.
    • Given our body is approximately 60% water by volume, MRI scans can be used to generate images over the length of our body.
    • In Australia, whole-body MRI was recently added to the Medicare Benefits Schedule for people with a high genetic risk of cancer.

The risk of overdiagnosis

    • The anxiety and potentially invasive investigations triggered by an MRI finding may have a negative effect on the person’s overall wellbeing.
    • The whole-body MRI offered by Prenuvo in the United States and promoted by Kardashian costs almost A$4,000.
    • Read more:
      Low- and middle-income countries struggle to provide health care to some, while others get too much medicine

How parts of the body talk to each other

    • Body systems that interact with the brain include the gut and heart.
    • The brain also partners with our musculoskeletal system and fat distribution in the body.
    • They further identified networks of advanced ageing patterns that spread from affected organs into other body systems.

Studying healthy people to track changes

    • A substantial number of people who will participate in these studies are healthy.
    • Over time, some of the study participants will develop health issues.
    • One of the key challenges in these large-scale imaging studies is how to identify relevant changes on MRI scans.
    • Read more:
      'Brain fingerprinting' of adolescents might be able to predict mental health problems down the line

Skin cancer screening guidelines can seem confusing – three skin cancer researchers explain when to consider getting checked

Retrieved on: 
Friday, August 11, 2023

And public health messaging around when and how to be screened for skin cancer has become somewhat confusing.

Key Points: 
  • And public health messaging around when and how to be screened for skin cancer has become somewhat confusing.
  • In April 2023, the U.S. Preventive Services Task Force, an independent national panel of science experts, provided updated recommendations on skin cancer screening following a systematic review of existing research.
  • The task force concluded that the evidence does not support annual widespread skin screening of adolescents and adults, but that catching cancers at the earliest stages reduces the risk of death from skin cancer.

How common is skin cancer in the US?

    • Skin cancer affects about 6 million Americans yearly, according to the Centers for Disease Control and Prevention.
    • Basal cell carcinoma and squamous cell carcinoma – collectively known as keratinocyte cancers – account for more than 97% of skin cancer cases, but invasive melanomas cause the most deaths.
    • Unlike normal cells, skin cancer cells grow without constraints, acquiring the ability to invade down into the dermis.

What are the main causes of skin cancer?

    • Both light- and dark-skinned people can get skin cancer, but light-skinned individuals have a greater risk.
    • Those with light skin, light or red hair, or with numerous moles, are more susceptible to skin damage and severe burns by ultraviolet rays.
    • People who use tanning beds are at a higher risk of skin damage and skin cancers.

What is the debate behind screening?

    • The ongoing debate revolves around whether more screening reduces the death toll from melanoma.
    • This increase may be due in part to more emphasis on early detection.
    • More melanomas have been found, particularly those identified at the earliest stage, also known as stage 0 or melanoma in situ.

What did the task force base its new recommendations on?

    • The task force reviewed current and past data on the major types of skin cancers.
    • The expert panel relied in part on the results of a large public skin cancer screening program in Germany.

When should you get a skin exam?

    • Luckily, there are many online guides on detecting suspicious skin lesions.
    • Whenever you have a concern about a spot on your skin, seek medical advice.
    • This includes those who are older or susceptible to getting skin cancers, skin cancer survivors and immunocompromised people like organ transplant recipients.
    • In response, nonprofits like the American Academy of Dermatology, the Skin Cancer Foundation and The Sun Bus provide resources for free exams.

How can you minimize the risk of skin cancer?


    Strategies that limit UV exposure will reduce skin cancer risk. This includes avoiding sunburns by:
    • Apply these products 15-20 minutes before heading out into the sun and reapply every two hours.
    • UV light is most intense between the hours of 10 a.m. to 4 p.m.
    • These measures can keep your skin healthy into your golden years by reducing skin aging and cancer caused by ultraviolet light.
    • Neil Box receives funding from the National Institutes of Health and the American Skin Association.

Prostate cancer treatment is not always the best option – a cancer researcher walks her father through his diagnosis

Retrieved on: 
Tuesday, August 8, 2023

As a cancer researcher who knows very well about the high incidence and decreased survival rates of prostate cancer in the Caribbean, I anguished over these words.

Key Points: 
  • As a cancer researcher who knows very well about the high incidence and decreased survival rates of prostate cancer in the Caribbean, I anguished over these words.
  • Even though I study cancer in my day job, I struggled to take in this news.
  • “They are recommending treatment.” However, I understood from my work that not undergoing treatment was also an option.

Prostate cancer diagnosis

    • His battle with his prostate health started 10 years ago with an initial diagnosis of benign prostate hyperplasia, or BPH.
    • Although research suggests that the factors that contribute to BPH similarly contribute to prostate cancer, there is no evidence that an enlarged prostate will necessarily develop into cancer.
    • PSA is a protein that both normal and cancerous prostate cells produce, and elevated amounts are considered red flags for prostate cancer.

Cancer risk categorization

    • I explained that categorizing how aggressive the cancer is and how far it has spread can help determine the best course of treatment.
    • Some patients with early-stage or intermediate-risk prostate cancer undergo additional treatment, including surgery, radiation or radioactive seed implants called brachytherapy.
    • Patients with late-stage prostate cancer typically undergo hormone therapy along with surgery or radiation, or chemotherapy with or without radiation.

Prostate cancer screening problems

    • Even with all my expertise studying cancer genetics and working with cancer patients, I couldn’t help second-guessing our decisions, and I sometimes questioned our decision not to immediately treat his cancer.
    • Nearly half of all patients with prostate cancer are overdiagnosed, often leading to overtreatment.
    • Several studies in the U.S. have shown that patients with early-stage prostate cancer have a good prognosis, and the cancer rarely progresses further.
    • Overdiagnosis and overtreatment of prostate cancer led the U.S. Preventive Services Task Force to recommend against PSA-based screening in 2012, with caveats for high-risk groups including African American men and those with a family history of prostate cancer.
    • Those recommendations have resulted in reduced screening and increased prostate cancer diagnoses.

Surviving prostate cancer

    • I still worry about my father’s diagnosis, because his cancer is at risk for progression.
    • His doctors are monitoring his PSA levels as part of his survivorship plan, which is a record of information about his cancer diagnosis, treatment history and potential follow-up tests.
    • Many were under the impression that prostate cancer required immediate treatment.